A Complete Guide to Maggot Therapy

Frank Stadler

Description

Since the revival of maggot therapy in Western wound care approximately thirty years ago, there has been no comprehensive synthesis of what is known about its clinical practice, supply chain management, and social dimensions. This edited volume fills the information vacuum and, importantly, makes the current state of knowledge freely accessible. It is the first to provide sound, evidence-based information and guidance covering the entire supply chain from production to treatment.

The chapters are arranged in five parts presenting the latest on clinical practice, the principles of therapeutic action, medicinal maggot production, distribution logistics, and the ethical dimensions of maggot therapy. The contributors have paid particular attention to the challenges encountered in compromised, low-resource healthcare settings such as disasters, conflict, and poverty.

There are still many barriers to the widespread uptake of maggot therapy in healthcare settings. This book will be essential reading for a global audience of doctors, nurses, allied healthcare providers, students, and entrepreneurs with an interest in maggot-assisted wound care. It will be the go-to reference for those who plan, regulate, and coordinate healthcare, and want to establish a maggot therapy program, particularly in low- and middle-income and other compromised healthcare settings where maggot therapy can provide much-needed, affordable, and efficacious wound care.

Sujets

• Médecine
• Médecine Générale
• Medical

Informations

• Publié par: Open Book Publishers
• Date de parution: 20 juillet 2022
• Nombre de lectures: 0
• EAN13: 9781800647312
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

A COMPLETE GUIDE TO MAGGOT THERAPY

A Complete Guide to Maggot Therapy
Clinical Practice, Therapeutic Principles, Production, Distribution, and Ethics
Edited by Frank Stadler





https://www.openbookpublishers.com
© 2022 Frank Stadler. Copyright of individual chapters is maintained by the chapters’ authors




This work is licensed under an Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). This license allows you to share, copy, distribute and transmit the text; to adapt the text for non-commercial purposes of the text providing attribution is made to the authors (but not in any way that suggests that they endorse you or your use of the work). Attribution should include the following information:
Frank Stadler (ed.), A Complete Guide to Maggot Therapy: Clinical Practice, Therapeutic Principles, Production, Distribution, and Ethics . Cambridge, UK: Open Book Publishers, 2022, https://doi.org/10.11647/OBP.0300
Copyright and permissions for the reuse of many of the images included in this publication differ from the above. This information is provided in the captions and in the list of illustrations.
Every effort has been made to identify and contact copyright holders and any omission or error will be corrected if notification is made to the publisher.
In order to access detailed and updated information on the license, please visit https:// doi.org/10.11647/OBP.0300#copyright . Further details about CC BY-NC licenses are available at http://creativecommons.org/licenses/by-nc/4.0/
All external links were active at the time of publication unless otherwise stated and have been archived via the Internet Archive Wayback Machine at https://archive.org/web
Digital material and resources associated with this volume are available at https://doi. org/10.11647/OBP.0281#resources
ISBN Paperback: 9781800647282
ISBN Hardback: 9781800647299
ISBN Digital (PDF): 9781800647305
ISBN Digital ebook (epub): 9781800647312
ISBN Digital ebook (azw3): 9781800647329
ISBN XML: 9781800647336
ISBN HTML: 9781800647343
DOI: 10.11647/OBP.0300
Cover image: Line drawing of a green bottle blowfly ( Lucilia sericata) maggot by Frank Stadler (2022), CC BY-NC. Cover design by Katy Saunders.

How to Cite
The book:
Stadler, Frank (ed.), A Complete Guide to Maggot Therapy: Clinical Practice, Therapeutic Principles, Production, Distribution, and Ethics (Cambridge: Open Book Publishers, 2022), https://doi.org/10.11647/OBP.0300 .
Individual chapters:
Stadler, Frank, ‘Introduction’, in A Complete Guide to Maggot Therapy: Clinical Practice, Therapeutic Principles, Production, Distribution, and Ethics , F. Stadler (ed.). 2022, Cambridge: Open Book Publishers, pp. xx–xx, https://doi.org/10.11647/OBP.0300.01.

Acknowledgements
This book would not have been possible without the in-kind support of the School of Medicine and Dentistry, Griffith University, and a generous financial contribution to the publication costs by the BioTherapeutics, Education & Research (BTER) Foundation. Some contributions made by Dr Stadler were informed by his doctoral research conducted at the Department of International Business and Asian Studies, Griffith University, and supported by a generous scholarship under the Australian Postgraduate Award scheme. Likewise, this book has benefited from images, illustrations, and insights drawn from a research project funded by Creating Hope in Conflict: A Humanitarian Grand Challenge, led by Dr Stadler and his colleagues at Griffith University between 2019 and 2021. The high scientific calibre and integrity on display across the 19 chapters is to a large part due to the fantastic team of expert co-authors as well as the many chapter reviewers we have drawn from both the book co-author team and the independent scientific community. The external independent reviewers included Nazni Wasi Ahmad, Chris Freelance, Martin Hall, Gautham Krishnaraj, Bryan Lessard, Anne Paas, Sebastian Probst, Hitoshi Takase, Tarek Tantawi, Aletha Tippett, Mark Wilson, and Martha Isabel Wolff Echeverri. Thank you, on behalf of the patients who will benefit from your work.

To William S. Baer and fellow pioneers of modern maggot therapy on whose shoulders we stand

Contents
How to Cite v
Acknowledgements vii
Contributor Biographies xxv
1. Introduction 1
Frank Stadler
Maggot Therapy and the Global Wound Burden 1
Maggot Therapy 3
Why a Book on Maggot Therapy? 5
Past, Present, and Future 9
References 10
Part 1 : Clinical Practice 15
2. Living with a Chronic Wound 17
Rajna Ogrin and Kylie J. Elder
Introduction 17
Wellbeing in People Living with Chronic Wounds 18
Physical Wellbeing 21
Psychological Wellbeing 24
Social Wellbeing 25
Spiritual/Cultural Wellbeing 26
How People with Chronic Wounds Seek, Access, and Experience Care 27
Summary 29
References 30
3. Wound Aetiologies, Patient Characteristics, and Healthcare Settings Amenable to Maggot Therapy 39
Ronald A. Sherman and Frank Stadler
Introduction 39
Wounds Amenable to Maggot Therapy 40
Population and Patient Characteristics 49
Summary 53
References 54
4 . Indications, Contraindications, Interactions, and Side-effects of Maggot Therapy 63
Ronald A. Sherman
Introduction 63
Indications for Maggot Therapy 64
Contraindications and Relative Contraindications for Maggot Therapy 67
Interactions between Maggot Therapy and Other Treatment Modalities 68
Warnings and Adverse Events Associated with Maggot Therapy 69
Summary 72
References 73
5. Medicinal Maggot Application and Maggot Therapy Dressing Technology 79
Ronald A. Sherman
Introduction 79
Maggot Therapy Dressings—Past and Present 80
Applying Maggot Dressings 83
Dressing Changes, Maintenance & Repair 88
Dressing Duration and Removal 89
Reapplication or Follow-up Treatment? 92
Summary 93
References 93
6. Clinical Integration of Maggot Therapy 97
Benjamin L. Bullen, Ronald A. Sherman, Paul J. Chadwick and Frank Stadler
Introduction 97
Institutional and Professional Considerations 99
Regulatory Considerations, Cost and Reimbursement 100
Organisational Considerations 109
Summary 110
References 111
Part 2 : Therapeutic Principles 119
7. The Natural History of Medicinal Flies 121
Michelle L. Harvey
Introduction 121
Life Histories 122
Morphology 123
Life-cycle and Developmental Traits of Calliphorid Flies 127
Environmental Factors Affecting Calliphorid Fly Behaviour 130
Calliphorid Interactions with Humans and Domesticated Animals 132
Lucilia—Friend or Foe? 134
Summary 136
References 136
8. Maggot Debridement 143
Yamni Nigam and Michael R. Wilson
Introduction 143
Efficacy of Maggot Therapy for Wound Debridement 144
The Feeding Process and Maggot Enzymatic Action 145
Identification of Maggot Enzymes in Debridement 146
Summary 148
References 149
9. The Antimicrobial Activity of Medicinal Maggots 153
Yamni Nigam and Michael R. Wilson
Introduction 153
Historical Investigations into the Antimicrobial Activity of Maggots 154
Resurgent Interest in Antibacterial Bioactivity from Maggots 155
Evidence for the Antimicrobial Activity of Medicinal Maggots 157
The Antimicrobial Compounds in Maggot Excretions and Secretions 160
Summary 167
References 169
10. Maggot-assisted Wound Healing 175
Yamni Nigam and Michael R. Wilson
Introduction 175
Early Studies on Maggot-led Healing 176
Randomised Controlled Trials on Wound Healing Using Maggots 178
Scientific Mechanisms by Which Maggots Promote Wound Healing 179
Summary 189
References 189
11. Bioprospecting and Testing of New Fly Species for Maggot Therapy 195
Patricia J. Thyssen, Franciéle S. Masiero and Frank Stadler
Introduction 195
Bioprospecting for Medicinal Fly Species 196
Pre-clinical Trials to Assess Nutritional Strategy, Safety, and Therapeutic Efficacy of Medicinal Maggots 199
Preclinical Research Protocols 203
Clinical Trials 211
Regulatory Approval 218
Clinical Use and Commercial Production 220
Summary 222
References 222
Part 3 : Production of Medicinal Maggots 235
12. Laboratory and Insectary Infrastructure and Equipment 237
Frank Stadler
Introduction 237
Production Laboratory Typology 239
Building and Space Requirements 244
Equipment Requirements 248
Summary 253
References 253
13. Fly Colony Establishment, Quality Control and Improvement 257
Frank Stadler, Nikolas P. Johnston, Nathan J. Butterworth, and James F. Wallman
Introduction 257
Medicinal Fly Species 259
Collecting Wild Flies 260
Taxonomic Identification and Confirmation of Species 266
Domestication of Fly Stock 275
Strain Improvement 278
Summary 279
References 279
14. Medicinal Maggot Production 289
Frank Stadler and Peter Taká č
Introduction 289
How to Care for Adult Flies 290
How to Care for Maggots 298
Pupariation 302
Disinfection of Medicinal Maggots 303
Incubation of Eggs 305
Quality Control 307
Supply Management and Perishability of Medicinal Maggots 308
Scheduling of Production Activities 310
Occupational Health and Safety 313
Sustainable Production and Waste Management 314
Medicinal Maggot Production in Healt