The role of Interleukin-12 in liver inflammation [Elektronische Ressource] : a study with transgenic mice / Jose Francisco García Lázaro

The role of Interleukin-12 in liver inflammation. A study with transgenic mice Dissertation zur Erlangung des Grades “Doktor der Naturwissenschaften” am Fachbereich Biologie der Johannes Gutenberg-Universität in Mainz Jose Francisco García Lázaro geboren in Palma de Mallorca Mainz, Juli 2005 Mündliche Prüfung: Mainz, den 11. November 2005 Table of contents ITable of Contents 1. Introduction.......................................................................................................................... 1 1.1 Hepatic immunity........................................................................................................ 1 1.2 Th1 (inflammatory) versus Th2 (non-inflammatory) immune responses............. 1 1.3 Antigen-presentation in the liver induces tolerance................................................ 2 1.4 Interleukin-12.............................................................................................................. 3 1.4.1 Structure................................................................................................................. 4 1.4.2 Production.............................................................................................................. 4 1.4.3 Receptor................................................................................................................. 4 1.4.4 Intracellular signalling pathway..................................