Anti-inflammatory effects of Radix Gentianae Macrophyllae(Qinjiao), Rhizoma Coptidis(Huanglian) and Citri Unshiu Pericarpium(Wenzhou migan) in animal models
7 pages
Obtenez un accès à la bibliothèque pour le consulter en ligne
En savoir plus

Anti-inflammatory effects of Radix Gentianae Macrophyllae(Qinjiao), Rhizoma Coptidis(Huanglian) and Citri Unshiu Pericarpium(Wenzhou migan) in animal models

-

Obtenez un accès à la bibliothèque pour le consulter en ligne
En savoir plus
7 pages

Description

KHU14, an ethanolic extract of Radix Gentianae Macrophyllae ( Qinjiao ), Rhizoma Coptidis ( Huanglian ) and Citri Unshiu Pericarpium ( Wenzhou migan ) was tested for its anti-inflammatory effects. Methods Three out of 20 herbs were found to have anti-inflammatory effects. The formulation of these herbs, i.e. KHU14 was tested for croton oil-induced ear edema, carrageenan-induced paw edema, acetic acid-induced capillary permeability, cotton pellet and delayed type hypersensitivity. Results KHU14 exhibited anti-inflammatory effects in animal models of acute and chronic inflammation. The anti-inflammatory activity of KHU14 observed was comparable to that of celecoxib. KHU14 inhibited the production of NO and PGE 2 in LPS/IFN-gamma-stimulated peritoneal macrophages, and reduced edema and the amount of infiltrated cells in animal models. Conclusion KHU14 exhibited anti-inflammatory effects as demonstrated in typical immunological tests for anti-inflammation in vitro and in vivo .

Sujets

Informations

Publié par
Publié le 01 janvier 2008
Nombre de lectures 26

Exrait

Chinese Medicine
BioMedCentral
Open Access Research Antiinflammatory effects ofRadix Gentianae Macrophyllae (Qinjiao),Rhizoma Coptidis(Huanglian) andCitri Unshiu Pericarpium (Wenzhou migan) in animal models 1 2 1 2 Kyoung Soo Kim* , Hae In Rhee , Eun Kyung Park , Kiwon Jung , 2 2 2 3 Hyo Jin Jeon , JiHong Kim , Hunseung Yoo , ChangKyun Han , Yong 4 5 6 7 Baik Cho , Chun Jeih Ryu , Hyung In Yang and Myung Chul Yoo*
1 Address: EastWest Bone and Joint Research Center, Kyung Hee University Neo Medical Hospital, 149 Sangildong, Gangdonggu, Seoul 134090, 2 South Korea, Life Science Research Center, SK Chemicals, 600 Jungja1dong, ChanganKu, SuwonSi, KyoungkiDo 440745, South Korea, 3 4 Central R&D, Ahngook Pharm., IuiDong Yeongtonggu, SuwonSi, KyoungkiDo, South Korea, Central Research Institute, Whan In Pharm., Co., 5 Ltd. IuiDong, Yeongtonggu, SuwonSi, KyoungkiDo, South Korea, Department of Bioscience and Biotechnology, Sejong University, Seoul 143 6 747, South Korea, Department of Internal Medicine, Kyung Hee University Neo Medical Hospital, 149 Sangildong, Gangdonggu, Seoul 134 7 090, South Korea and Department of Orthopedic Surgery, Kyung Hee University Neo Medical Hospital, 149 Sangildong, Gangdonggu, Seoul 134090, South Korea
Email: Kyoung Soo Kim*  labrea46@yahoo.co.kr; Hae In Rhee  hilee@skchemicals.com; Eun Kyung Park  pkeun1728@empal.com; Kiwon Jung  jm92@korea.com; Hyo Jin Jeon  hyjinjeon@skchemicals.com; JiHong Kim  jihong.kim@skchemicals.com; Hunseung Yoo  romio98@skchemicals.com; ChangKyun Han  ckhan@ahngook.com; YongBaik Cho  ybcho@whanin.com; Chun Jeih Ryu  cjryu@sejong.ac.kr; Hyung In Yang  yhira@khu.ac.kr; Myung Chul Yoo*  mcyookuh@chol.com * Corresponding authors
Published: 2 September 2008 Received: 14 June 2007 Accepted: 2 September 2008 Chinese Medicine2008,3:10 doi:10.1186/17498546310 This article is available from: http://www.cmjournal.org/content/3/1/10 © 2008 Kim et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background:KHU14, an ethanolic extract ofRadix Gentianae Macrophyllae(Qinjiao),Rhizoma Coptidis(Huanglian) andCitri Unshiu Pericarpium(Wenzhou migan) was tested for its anti inflammatory effects.
Methods:Three out of 20 herbs were found to have antiinflammatory effects. The formulation of these herbs, i.e. KHU14 was tested for croton oilinduced ear edema, carrageenaninduced paw edema, acetic acidinduced capillary permeability, cotton pellet and delayed type hypersensitivity.
Results:KHU14 exhibited antiinflammatory effects in animal models of acute and chronic inflammation. The antiinflammatory activity of KHU14 observed was comparable to that of celecoxib. KHU14 inhibited the production of NO and PGE in LPS/IFNgammastimulated 2 peritoneal macrophages, and reduced edema and the amount of infiltrated cells in animal models.
Conclusion:KHU14 exhibited antiinflammatory effects as demonstrated in typical immunological tests for antiinflammationin vitroandin vivo.
Background Herbal extracts from traditional Chinese medicine can be formulated to develop novel herbal medicines as potent
as synthetic medicines [13]. We investigatedin vitroanti inflammatory properties of 20 medicinal herbs used in Chinese medicine in order to develop a new herbal for
Page 1 of 7 (page number not for citation purposes)
  • Accueil Accueil
  • Univers Univers
  • Livres Livres
  • Livres audio Livres audio
  • Presse Presse
  • BD BD
  • Documents Documents