Simarouba cedron FHP / Cedron PPH

Ansm

Description

Pharmacopée française - Préparations homéopathiques
07/06/2012

Sujets

• Anglais
• Médecine

Informations

• Publié par: ansm-pharmacopee-francaise
• Publié le: 07 juin 2012
• Nombre de lectures: 25
• Licence : En savoir +
  Paternité, pas d'utilisation commerciale, pas de modification
• Langue: English

Extrait

 

SIMAROUBA CEDRON FOR HOMOEOPATHIC PREPARATIONS

 CEDRON  FOR HOMOEOPATHIC PREPARATIONS  Simaba cedron ad praeparationes homoeopathicas  Other Latin name used in homoeopathy:Simaruba   DEFINITION  Dried cotyledons of the seed ofSimaba cedronPlanch. (Quassia cedron.)nolliaB  Content: minimum 0.15 per cent of quassinoids, expressed as santonin (C 15 H 18 O 3 ;M r 246.3) (dried drug).   CHARACTERS  Macroscopic and microscopic characters described under identification tests A and B.   IDENTIFICATION  A. Roughly elliptic organs, 3 cm to 5 cm long and 15 mm to 20 mm large. One side is convex the other one is flatter. Yellowish or greyish surface in some places, showing bumps and irregular shapes due to dessiccation. The inside is of a paler yellow.  B. Reduce simarouba cedron to a powder (355). The powder is light brown. Examine under a microscope using hydrate solution R. chloralNumerous fragments of cotyledons composed of round to ovoid cells, with cellulose walls; rare wood vessels with spiral patterns. Examine under a microscope usingglycerol per cent (50 V/V) R.Numerous starch granules rounded or truncated mostly simple, a few being two to three compounds.  C. Thin layer chromatography (2.22.7).  Test solution. Add 30 mL ofethanol(65 per centV/V)Rto 3 g of the drug properly divided. Heat under a reflux condenser for 15 min. Allow to cool. Filter.  Reference solution. Dissolve 10 mg ofrutin Rand 10 mg ofisoquercitroside Rin 30 mL of ethanol(96 per cent)R.   Plate:TLC silica gel plate R.   Mobile phase:water R,anhydrous formic acid R,ethyle acetate R(10:10:80V/V/V).  Application: 30 µL, as bands.  Development: over a path of 10 cm.  Drying: in air.

 ____________________________ The General Chapters and General Monographs of the European Pharmacopoeia and Preamble of the French Pharmacopoeia apply.   F r e n c h P h a r m a c o p o e i a 2 0 0 7