The potential of the human kidney cell line, Caki-1, as an in vitro screening system for drug interactions with organic cation transporters [Elektronische Ressource] / Natalie Glube

The potential of the human kidney cell line, Caki-1, as an in vitro screening system for drug interactions with organic cation transporters Dissertation zur Erlangung des Grades „Doktor der Naturwissenschaften“ am Fachbereich Chemie, Pharmazie und Geowissenschaften der Johannes Gutenberg-Universität Mainz Natalie Glube, BSc. geb. in Halifax, Canada Mainz, 2007 Tag der mündlichen Prüfung: September 14, 2007 “research is discovering God’s secrets” 7Table of Contents Abbreviations....................................................................................................................11 1. Introduction...................................................................................................................15 1.1 The pharmacological role of the kidney .....................................................................15 1.1.1 General structural and functional organization of the kidney ...............................15 1.1.2 General functions of the kidney ...........................................................................16 1.1.3 Renal drug-handling processes (renal clearance) ...............................................16 1.1.4 Glomerular filtration (GF).....................................................................................17 1.1.5 Tubular secretion.................................................................................................17 1.1.6 Tubular reabsorption................