CELTIC RELIGION The Ancient Celts

Toxi_2

Description

• expression écrite - matière potentielle : by classical authors
• cours - matière potentielle : the year
• expression écrite

CELTIC RELIGION The Ancient Celts The Celts originated, as far as is known, in the eighth century BC in Eastern Europe - probably Hungary and Czechoslovakia - from where they migrated across Europe and were known as “Galates” by the Greeks and “Gauls” by the Romans. The first mention in Classical writing that has survived dates back to about 500BC. However, most of the references to this elusive people are of later date.

• such temple
• original megalith builders
• wooden dolls
• arrogant assumption of celtic religion as a primitive reflection
• gaul
• god of war
• bronze
• celtic
• forest
• people

Sujets

• Frazer
• Somme (département)
• Oise (département)
• Apollo
• Caesar
• Delphi
• Empire

Informations

• Publié par: undre
• Nombre de lectures: 21
• Langue: English

Extrait

Course5.6InsilicoADME&Predictive Toxicology 7‐11May2012 FacultyofPharmaceuticalSciences, UniversityofCopenhagen HomeAssignment(CaseStudiesandCoursequestions) nd Tobecompletedbythe22 June2012

InsilicoADME&PredictiveToxicologyCourse: Keyquestionstobetackledbythecourse

Thedrugdiscoveryanddevelopmentprocess‐withspecial ž focusonADME/Tox ž AbsorptionanddistributionfromaPKpointofview Criticalanalysisofexperimentaldata ž Predictionofabsorptionanddistribution ž ž PhaseIandIImetabolism‐ThecytochromeP450enzymes ž Predictionofmetabolism‐Classification Predictionofmetabolism‐Siteofmetabolism ž Predictionoftoxicity(e.g.genotoxicity,phospholipidosis, ž hERGetc.) Genomiceffectsonmetabolismandtoxicity ž ž DifferentQSARsystemsavailable

Introduction TheInsilicoADME&PredictiveToxicologycourseispartofthenewEuropean MastersdegreeforAdvancedSafetySciencesforMedicinesdesignedby SafeSciMETaspartoftheEuropeanInnovativeMedicinesInitiative(IMI). SafeSciMETisauniquepanEuropeannetworkofacademicsandpharmaceutical industrywhohavecometogethertoestablishacomprehensiveSafetySciences ModularEducation&Trainingprogrammecoveringallaspectsofsafetyindrug developmenttoensureEuropeanDrugSafetyScientistsinthepharmaceutical industry,regulatoryauthoritiesandacademiaareattheforefrontoftheirfield. Whyjointhecoursein InsilicoADME&PredictiveToxicology? Theuseofinsilicomethodsinthedrugdiscoveryanddevelopmentprocess becomesmoreandmoreimportant.Predictiveinsilicomethodsaregetting considerablemorereliable,theycoverabroaderspectrumofpredictiveend‐ points,andtheyaregettingeasiertousefornon‐specialists.Reliablepredictive modelsmayreplacecostlyexperimentsandtherebycontributetoacost‐ reductionofthedrugdiscoveryanddevelopmentprocess.Furthermore,insilico methodsmakesitpossibletohandleandevaluatelargedatasetsandthereby coveringthechemicalandpharmacologicalspacemoreextensively. CourseObjectives Thiscourseconsistsof5daysinCopenhagenwithlectures,practicalexercises, groupworkanddiscussionsfollowedbyaweekathomededicatedtoan individualassignment.Thus,thetotalcoursewillprovidetheparticipantswitha comprehensiveoverviewofinsilicomethodsinthedrugdiscoveryand developmentprocess,whereinsilicomethodscanbeused,andwhataretheir strengthsandweaknesses.Furthermore,youwillgethands‐onexperiencewith severalpredictiveinsilicomethodsaswellasanintroductiontotheprinciple behindthemethods.Duringtheindividualassignmentyouwillgetthe opportunitytofocusfurtheronmethodsrelevantforyourinterestand employment. Forkeytopicscoveredatthecourse,seebackofbrochure.

TargetGroup SafeSciMETstudents,academicsandworkersinthepharmaceuticalindustryand regulatoryauthoritieswhoneedabroadcomprehensiveunderstandingofthedrug developmentprocesswithparticularemphasisonsafety. Learningoutcomes Thecourseprovidestheparticipantswithanintroductionandhands‐onexperiencewith insilicomethodsforpredictionofvariousADME/Toxrelevantend‐points. Morespecifically,participantswillbeableto: ∙Useweb‐basedtoolsforpredictionofsimpleADME/Toxend‐pointslikedrug‐likeness, solubility,absorption,genotoxicity,phospholipidosisetc. ∙UsepurposedevelopedcomputationaltoolsforpredictionofcomplexADME/Tox end‐pointslikepredictionofmetabolism(classification)andsiteofmetabolism ∙Understandtheprinciplesbehindthemostcommonlyusedtypesofpredictive methods ∙Exploreandunderstandthediversityofalargedataset

CourseProgramme TheSyllabus Asyllabuscontaininganintroductorychapter,lecturehandouts,listofabbreviations, definitionsandreadingmaterialswillbeprovidedbythecourseleader14dayspriortothe course.Thematerialforthehomeassignmentwillbeprovidedduringthefirstweekofthe course.

Assessment Theassessmentisbasedona2‐hourwrittenexaminationonthelastdayofthecourseandon theevaluationofthehomeassessment

Type Assessors(s) Examaids Courseadministrator:

Thepurposeoftheexaminationistotestthat theexamineehasabroadknowledgeand comprehensionofwhereinthedrugdiscovery anddevelopmentprocessinsilicomethods maybeapplied,strengthsandlimitations associatedwithdifferenttypesofpredictive methods,andspecificexperienceswithsome representativeinsilicomethods

CourseDirectors Allwrittenexamaidsareallowed ProfessorFlemmingSteenJørgensen DepartmentofMedicinalChemistry FacultyofPharmaceuticalSciences UniversityofCopenhagen Universitetsparken2 DK‐2100Copenhagen,Denmark Phone:[phone] Mail:[e-mail]

PracticalInformation CourseCredits:3ECTScredits Level:Master’slevel(secondcyclehighereducation) CourseDates: 7‐11May2012 Location:TheFacultyofPharmaceuticalSciences,Universityof Copenhagen,Universitetsparken2,DK‐2100Copenhagen, Denmark Teachingmethods:Lectures,practicalexercises,groupwork,presentationsand discussions.Inordertoprovidetheparticipantswith practicalexperiencewithinsilicopredictivemethods, approximatelyhalfofthecoursewillbepracticalexercises andgroupwork. StudentWorkload:Preparation:10hours Course:38hours Examination:2hours Assignment:40 Total:90hours CourseFee:2,500Euro—750Euro(dependentoncategoryofstudent) (pleasevisitwww.SafeSciMET.eu.Howtoapplyformore information) Applicationdeadline:7April2012 CourseCapacity:24participants Language:TheofficiallanguageofthecourseisEnglish. Nosimultaneoustranslationswillbeprovided Coursenotes:Notes(literature)usedinthecourse Courseaccreditation:Thecoursemeetsthecriteriaforcontinuousprofessional Development(CPD)diplomas,anditwillbepartofa (forthcomingEuropean)MastersofAdvancedSafety Sciencesdegree. Moreinformationcanbeobtainedthroughourwebsite: http://www.SafeSciMET.eu

CourseLeaders ProfessorFlemmingSteenJørgensen DepartmentofMedicinalChemistry,FacultyofPharmaceuticalSciences, UniversityofCopenhagen,Denmark Dr.AlexanderAmberg R&DDSAR/PreclinicalSafetyFrankfurt, Sanofi‐AventisDeutschlandGmbH,Germany CourseTeachers ProfessorGerhardEcker PharmacoinformaticsResearchGroup,DepartmentofMedicinalChemistry, UniviversityofVienna,Austria ProfessorChrisOostenbrink IntituteofMolecularModelingandSimulation,UniversityofNaturalResources andLifeSciences,Vienna,Austria AssociateProfessorLarsOlsen DepartmentofMedicinalChemistry,FacultyofPharmaceuticalSciences, UniversityofCopenhagen,Denmark Dr.ArmelStockis GlobalExploratory,tneBCUveDepmloPharmaS.A.,Brussels,eBgluim Dr.GrahamWishart DrugDispositionEurope,LillyUK,Windlesham,UnitedKingdom Dr.UlfNorinder AstraZenecaResearch&Development,Södertälje,Sweden

REGISTRATION Pleasevisitwww.safescimet.eutoregister.Onthehomepage,pleasegotoHowto pplyandsignup: ForMScofAdvancedSafetyCourses ForContinuingProfessionalDevelopment(CPD) ForSinglecourses

Youwillbenotifiedthatyourregistrationhasbeenreceived

Theclosingdatetoregisterforthiscourseis7 April2012

Pleasenotethatthenumberofparticipantsislimitedto24. Itishighlyadvisabletosendinyourregistrationformassoonaspossible. Registrationwillbemadeonafirstcomefirstservedbasis

TRANSPORT The course takes place in central Copenhagen, 12 km from the airport and 5 km from the city center. Several bus lines serve the course site.

ACCOMMODATION Hotels can be arranged individually via www.visitcopenhagen.dk

CANCELLATION Cancellation of a pre-registered student is possible, upon written notice by 20 April 2012. Before that date the Course fee will be refunded except for an administrative fee of EUR 75. After that date, no refunds can be made for cancellations