http://www.mbi.ucla.edu/About/MBI_history.html). .... Audrey Agopian, Postdoctoral Fellow, Laboratory of Zhefeng Guo ...... We are investigating the role of this gene, termed vpr, and the specific ...... collaborating with the Berkeley Drosophila Genome project (BDGP) in the analysis and documentation of developmentally ...
University of California
Los Angeles
September 2010
Number 46
Table of Contents
Page
No.
REPORT FROM THE DIRECTOR – STEVEN CLARKE 3
MBI COMMITTEES 5
MBI PROGRAMS AND EVENTS
The Paul D. Boyer Professorship in Molecular Biology and Biochemistry 6
David S. Sigman Memorial Lectureship and Symposium 7
th 12 Annual Postdoctoral Recognition Awards 8
The Audree Fowler Fellows in Protein Science 9
Thursday Seminar Series 10
Tuesday Faculty Research Club 13
MBI FACULTY RESEARCH AND PROFESSIONAL ACTIVITIES
Faculty Comments on their Research 15
Faculty Honors and Awards 71
Faculty Service on UCLA Committees 74
Service with Study Sections and Other Evaluation Committees 83
Service on Editorial Boards of Scientific Journals 90
Service in National Scientific Organizations 96
Patents Issued 101
Visiting Faculty and Scholars 103
RESEARCH SUPPORT FACILITIES AND SERVICES
UCLA-DOE-MBI Biochemistry Instrumentation Facility 105
UCLA-DOE-MBI Computational Technology Center 105
UCLA-DOE MBI Crystallization Core Facility 106
UCLA-DOE-MBI Electron Microscope Facility 106
UCLA-DOE-MBI NMR Core Facility 107
UCLA-DOE-MBI Protein Expression Technology Center 107
UCLA-DOE-MBI X-ray Crystallography Technology Center 108
JCCC Tissue Culture Core Facility 109
GRADUATE PROGRAMS
Molecular Biology Interdepartmental Ph.D. Program (MBIDP) 110
Whitcome Fellows Program 110
Cellular & Molecular Biology Training Grant 119
ADMINISTRATIVE SUPPORT STAFF ACTIVITIES
120 Administrative Services
121 Building Manager/Storeroom Services
APPENDIX I: Space Utilization 122
APPENDIX II: Faculty Publications 123
Report from the Director
Steven G. Clarke
Once again, we've had a happy and productive year - new members, new awards and honors, and new
initiatives.
With sadness we noted the passing of two individuals whose contributions to the institute were of
major importance. Emil L. Smith (1911 – 2009) came to UCLA in 1963 as chair of the department of
Biological Chemistry. He arrived at UCLA at about the same time as Paul Boyer and both served on
the initial advisory committee for the proposed Molecular Biology Institute. Emil's role in shaping
biochemistry at UCLA was well documented in Dick Dickerson's 2009 history of the MBI - "The
Making of an Institute: -The MBI at UCLA 1968-1978". (If anyone would like a hard copy of this
wonderful book please let Bo Tendis know; it is also available on the MBI web site at
http://www.mbi.ucla.edu/About/MBI_history.html). Emil was a pioneer in using the results from
amino acid sequencing to understand molecular evolution. In 1962, he was elected to the National
Academy of Sciences and in 1987 won the Stein-Moore Award of the Protein Society.
James B. Peter (1933 – 2009) was another pioneer in the MBI whose generosity to UCLA was capped
last year in a major gift with his wife Joan for the endowment of the "Paul D. Boyer Professorship in
Molecular Biology and Biochemistry". Jim was a graduate student of Paul Boyer's at Minnesota and
accompanied Paul to UCLA in 1963 to help set up the new lab. He had a long and distinguished career
capped by his 1975 founding and continuing presidency of Specialty Laboratories, a company that
developed many clinical assays using state-of-the-art immunological and mass spectrometric
technologies. Jim was honored by UCLA in 2001 with the Glenn T. Seaborg Medal for his significant
contributions to chemistry. Last November, members of the Peter family joined us in the awarding of
the inaugural Boyer chair to David Eisenberg (please see the write-up later in this report).
We also celebrated a number of major awards to our members including the election of Utpal Banerjee
and Bob Goldberg to the American Academy of Arts and Sciences, the Ernst Jung Medical Award to
Stephen Young, the Kettering Award of the American Society of Plant Biologists to Sabeeha
Merchant, a Sloan Research Fellowship to Grace Xiao, and the Elizabeth W. Jones Award for
Excellence in Education of the Genetics Society of America to Utpal Banerjee. Two UCLA faculty
won campus-wide awards as well - Al Courey received the UCLA Distinguished Teaching Award and
Dick Weiss won the UCLA Academic Senate Diversity, Equity, and Inclusion Award.
We welcomed eleven new members and associate members this year. New members included David
Brooks, Assistant Professor in MIMG, Pascal Egea, Assistant Professor in Biological Chemistry,
William Gelbart, Professor in Chemistry and Biochemistry, Patrick Harran, Professor in Chemistry and
Biochemistry, Kendall Houk, Professor in Chemistry and Biochemistry, Harley Kornblum, Professor
in Molecular Medicine and Pharmacology, Jorge Torres, Assistant Professor in Chemistry and
Biochemistry, and Xiandong William Yang, Professor in Psychiatry and Biobehavioral Sciences.
New Associate members included Andrew Diener, Assistant Professor in MCDB, Zhefeng Guo,
Assistant Professor in Neurology, and Martha Lewis, Assistant Professor in Medicine.
One issue came up this year that was of some concern to many of us. We learned in January that we
hadn't looked closely enough at the plans for the new South Campus Student Center (Bombshelter
replacement) when they were presented to us in February of 2009. The problem is that the design
allowed no east-west access across the courtyard, effectively cutting us off from the CNSI. A group
including myself, David Eisenberg, Arnie Berk, Dick Dickerson, Paul Weiss, and Paul Boyer appealed
3
to Chancellor Block to see if this could be remedied. In June, we learned that our efforts had resulted
in the revision to the plan to allow east west access on a pathway underneath the planned hill (see
photos below).
February
2010 Plan -
Revised June 2010 plan looking southwest from No access
Boyer Hall west entrance with more direct access along the
across the courtyardred line!
Revised June 2010 plan looking southwest from
Boyer Hall west entrance with more direct access June 2010 plan looking northwest from Boyer Hall west
across the courtyard entrance
This June marked the end of the ninth year that I have directed the MBI. The Dean of Life Sciences,
Victoria Sork, has asked me to stay on for one more year while planning goes on for the transition to a
new director for July 1, 2011. Dean Sork chairs the Biosciences Initiative Advisory Committee, whose
membership includes several MBI members. This committee has recommended new directions for the
MBI in quantitative biology and systems biology. I am hopeful that I will leave the MBI as strong and
vibrant as I found it!
4
MBI COMMITTEES 2009-2010
MBI Advisory:
Utpal Banerjee (Chair), Al Courey, David Eisenberg, Michael Gresser,
Michael Grunstein, and Jeffery F. Miller
MBI Council:
Arnie Berk, Jim Bowie, Feng Guo, Jay Gralla, Reid Johnson, Frank Laski,
Beth Lazazzera, Karen Lyons, Fuyu Tamanoi and Steve Young
Space Sub-Committee: Berk, Bowie, Guo, Gralla, Laski
Membership Sub-Committee: Johnson, Lazazzera, Lyons, Tamanoi, Young
Molecular Biology Interdepartmental Ph.D. Program
(MBIDP):
Steven Clarke (MBIDP Chair), Mike Carey (Whitcome Fellowship Chair),
Peter Bradley, Guillaume Chanfreau, Jau-Nian Chen, Chris Denny, Tim Lane,
Sabeeha Merchant, Peter Tontonoz, Gerry Weinmaster, Sue Ellen Parsee
(SAO)
MBI Thursday Seminar Series:
Carla Koehler (Chair), Arnie Berk, Jau-Nian Chen, Juli Feigon, Kent Hill, Reid
Johnson, Sabeeha Merchant, Michael Teitell, Gerry Weinmaster, Steve Young
MBI Retreat Planning for October 2010:
Sue Ellen Parsee (SAO), MBIDP Students Akanksha Chhabra, Matt Denholtz,
Gabriel Ferguson, Lynn Lehmann, and CBI Trainee Brett Lomenick
5
MBI Programs and Events
THE PAUL D. BOYER PROFESSORSHIP
IN MOLECULAR BIOLOGY AND BIOCHEMISTRY
The Paul D. Boyer Professorship in Molecular Biology and Biochemistry was
established in 2009 in the UCLA College of Letters and Science from a very
generous gift from Joan and James B. Peter. The Peter family named the
chair in honor of Professor Paul Boyer, Nobel Laureate, founding director of
the UCLA Molecular Biology Institute, and the Ph.D. advisor of the late
James Peter at the University of Minnesota. The chair provides research
support for a named faculty member in the fields of molecular biology and
biochemistry.
Jim and Paul
Dr. Peter moved with Dr. Boyer to UCLA in 1963 and subsequently joined the UCLA faculty. In
1975, Dr. Peter founded Specialty Laboratories with the mission “help doctors help patients” and a
“house special” of the esoteric assay. Dr Peter continued his scientific work, publishing more than 450
papers focused on advanced molecular diagnostics.
In a ceremony on Wednesday, December 2, 2009, the inaugural Boyer
Chair was awarded to MBI member David S. Eisenberg, Ph.D., Professor
of Chemistry & Biochemistry and Biological Chemistry at UCLA, and
Director of the UCLA-DOE Institute of Genomics and Proteomics. Paul
and Lyda Boyer attended the festivities, as did members of Jim Peter’s
family. It was an opportunity to acknowledge Jim’s kindness and
generosity to the MBI over the years, and to honor David for his stellar
research and leadership. A special bronze-caste “Boyer Chair” was
presented to David by Gerald Levey, Dean of the UCLA Geffen School of
Medicine.
Congratulations, David!
With deepest appreciation to the Peter Family.
L-R: Joani Peter Noneman, Christine Peter Gard, Joan Peter, Paul & Lyda Boyer with
grandson Josh Boyer, Lucy & David Eisenberg, Deb Peter Estes & Arthur Peter
6
M