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Joe Archibald

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Costi Sifri, M.D., University of Virginia Health Sciences Center. Todd A. Fehniger, M.D., ..... postdoctoral fellowship in neuroimaging and genetics under the ..... HIV-1 vpr causes DNA damage in human proximal tubule cells: insights into the mechanism of. HIV-associated ...... strated that DOC and DEX trans-repressed inflam- ...

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• Publié par: paul.vallen
• Nombre de lectures: 26
• Langue: English
• Poids de l'ouvrage: 1 Mo

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2009 Meeting of Medical Fellows, Research Scholars, and Physician-Scientist Early Career Awardees Research Training Fellowships for Medical Students HHMI-NIH Research Scholars Program Physician-Scientist Early Career Award Program and Abstracts May 17–20, 2009 Office of Grants and Special Programs3 Introduction 4 Program Schedule 8 Keynote Speaker 9 2008 Early Career Awardees’ Biographies 15 Physician-Scientist Career Panel Members’ Biographies 16 Schedule of Presentations 29 Abstracts of Presentations 103 Howard Hughes Medical Institute Tr ustees Officers Grants and Special Programs 104 Participants 109 Index of Presentation Times 113 HHMI Conference Center Map HHMI Home Page www.hhmi.org Grants and Special Programs www.hhmi.org/grants HHMI Scientists and Research www.hhmi.org/research HHMI News www.hhmi.org/news GrantsNet www.grantsnet.orgCover: Tissues of the developing heart respond to a coordinated series of extracellular signals to form the many distinct anatomical features of the mature organ. Disruption of these signaling networks contributes to congenital heart disease, the most common class of birth defects. Among these signals, vascular endothelial growth factor (VEGF) family members are critically important; however, their specific temporal roles remain incompletely defined. Using chemical-induced expression of VEGF inhibitors in trans- genic mouse embryos, we have characterized time windows during which VEGF has three distinct functions during heart develop- ment. One of these functions is to coordinate cell survival to sup- port ventricle septation, as expression of an inhibitor of VEGF signaling (VEGFR2T) at embryonic day 11.5 (E11.5) prevents endothelialization of the ventricles and causes apoptosis specifically within the interventricular septum. These results provide a frame- work to understand how perturbations of VEGF signaling con- tribute to congenital heart defects. The cover image shows immunofluorescent staining of the inter- ventricular septum of a heart from an E13.5 embryo in which VEGF signaling has been blocked by the expression of VEGFR2T. Smooth muscle actin stains myocardial cells (red), PECAM stains endothelial cells (blue), and active caspase-3 stains apoptotic cells (green). Nuclei (grey) are stained with Hoechst. See abstract on page 35. (Courtesy of Gene Kew Ma, HHMI Medical Fellow, Department of Medicine, Stanford University School of Medicine. Mentor: Ching- Pin Chang, M.D., Ph.D.)INTRODUCTION Another way for you to continue your associa-Welcome to the 2009 Meeting of Medical Fellows, tion with HHMI and fellow trainees is through Research Scholars, and Physician-Scientist Early the HHMI Alumni Network, which comprisesCareer Awardees of the Howard Hughes Medical current and former awardees. Local networks haveInstitute. We are very pleased that participants been established in Boston, Northern California,from both HHMI medical education programs will Washington, D.C./Baltimore, Southern California,be sharing their research and expertise in this one North Carolina, Chicago, Michigan, the Pacificmeeting and will be joined by the 2008 awardees of Northwest, Texas, Cleveland, and New York City.our Physician-Scientist Early Career Award program. We invite you to become involved in the HHMIIn 1985, HHMI launched the HHMI-NIH alumni group nearest you and affiliate with newResearch Scholars Program in partnership with the groups as you move about the country during yourNational Institutes of Health to provide outstand- training and early career. ing students from U.S. medical schools with the This meeting is held each spring so that you canopportunity to receive a year of research training present your research and exchange ideas. We haveat NIH. Then, in 1989, HHMI established the grown accustomed to high-quality work from ourResearch Training Fellowships for Medical Students awardees, and this year’s presentations, as judged byProgram to provide a similar group of students the abstracts, will be no exception. We congratulatewith research training in leading academic research you on your scientific accomplishments and devel-laboratories beyond NIH. Recent years have seen opment, and we want to convey our appreciation the expansion of both of the programs to include to your mentors and preceptors, whose guidance isdental and veterinary students, and we welcome clearly evident.their participation. In speaking with numerous alumni of ourThe Physician-Scientist Early Career Awards medical education programs, we are impressed byprovide five years of research support to selected the pivotal effect that this research opportunity hasalumni of the HHMI Research Training Fellowships had on their career development. We hope that youand HHMI-NIH Research Scholars Program as will view your HHMI research experience similarlythey begin their independent academic careers. The and that you will pursue further research and, ulti-awardees will be giving oral presentations, partici- mately, rewarding careers as physician-scientists.pating in a career panel discussion on Monday Finally, we are interested in your comments andevening, and co-chairing presentation sessions with suggestions regarding both this meeting and thethe Medical Fellows and Research Scholars. Medical Fellows, Research Scholars, and Physician-Since the inception of the research training and Scientist Early Career Award programs in general.development programs, HHMI has supported more Please direct your feedback to your respectivethan 2,000 Medical Fellows and Research Scholars, program as follows: Medical Fellows Program toand 52 Early Career Awardees. This year, 74 Medical Melanie Daub at [e-mail]; ResearchFellows, 49 Research Scholars, and 18 Early Scholars Program to Min Lee at research_scholarsCareer Awardees will be presenting their research. @hhmi.org; and Physician-Scientist Early CareerThis book contains the schedule and abstracts of Award to Anh-Chi Le at [e-mail] presentations. We look forward to hearing about your researchWe are delighted to have Richard P. Lifton, M.D., and to following your careers in the years ahead.Ph.D., as our honored speaker this year. Dr. Lifton is an HHMI investigator, chairman of the Depart- Robert Tjian, Ph.D., Presidentment of Genetics, Sterling Professor of Genetics and Internal Medicine, and director of the Yale Peter J. Bruns, Ph.D., Vice PresidentCenter for Human Genetics and Genomics at Yale Grants and Special ProgramsSchool of Medicine. He will discuss his laboratory’s research using genetic approaches to identify the William R. Galey, Ph.D., Directorgenes and pathways that contribute to common Graduate and Medical Education Programshuman diseases, including cardiovascular, renal, and bone disease. We hope that the meeting will not only be a time for sharing and learning, but also a time for you to get to know your future physician-scientist colleagues better. In keeping with this objective, we have provided several informal opportunities for you to interact and network with each other. 3PROGRAM SCHEDULE 2009 MEETING OF MEDICAL FELLOWS, RESEARCH SCHOLARS, AND PHYSICIAN-SCIENTIST EARLY CAREER AWARDEES HHMI HEADQUARTERS AND CONFERENCE CENTER, CHEVY CHASE, MARYLAND Sunday, May 17, 2009 5:30–6:00 p.m. Welcoming Reception, Research Scholars and Medical Fellows, Great Hall 5:30–7:00 p.m. Dinner, Early Career Awardees, Rathskeller 6:00–7:00 p.m. Dinner, Research Scholars and Medical Fellows, Dining Room 7:00 p.m. Opening Remarks, Auditorium William R. Galey, Ph.D., Director, Graduate and Medical Education Programs Howard Hughes Medical Institute Welcoming Remarks Peter J. Bruns, Ph.D., Vice President, Grants and Special Programs Howard Hughes Medical Institute Early Career Awardees Introductions Panel Discussion: Pathway to Becoming a Physician-Scientist Moderator: William R. Galey, Ph.D. Early Career Awardee Panelists: Ari Green, M.D., University of California, San Francisco, School of Medicine Regina LaRocque, M.D., Massachusetts General Hospital Eduardo Méndez, M.D., University of Washington Medical Center Mark Onaitis, M.D., Duke University School of Medicine Rathskeller open until 10:30 p.m. 4PROGRAM SCHEDULE Monday, May 18, 2009 8:00 a.m. Breakfast, Dining Room 9:00–10:30 a.m. Platform Presentations Biomedical Engineering, Biochemistry, and Bioinformatics, Room D-124 Molecular and Cancer Biology, Room D-125 Cancer Biology I, Auditorium 10:30–10:45 a.m. Break, Great Hall 10:45 a.m.– 12:30 p.m. Platform Presentations Immunology and Developmental Biology I, Room D-124 Vascular and Cell Biology, Room D-125 Cancer Biology II, Auditorium 12:30 p.m. Lunch, Dining Room and Rathskeller 1:30–2:45 p.m. Early Career Awardees’ Plenary Presentations, Auditorium John T. Chang, M.D., University of Pennsylvania School of Medicine Yvonne R. Chan, M.D., Univittsburgh School of M Costi Sifri, M.D., University of Virginia Health Sciences Center Todd A. Fehniger, M.D., Ph.D., Washington University School of Medicine 2:45–3:00 p.m. Break, Great Hall 3:00–4:00 p.m. Poster Session A, Atrium 4:00–5:00 p.m. Poster Session B, Atrium 5:00–5:30 p.m. Reception, Atrium 5:30–7:00 p.m. Dinner, Dining Room 7:00 p.m. Keynote Speaker, Auditorium Richard P. Lifton, M.D., Ph.D., Investigator, Howard Hughes Medical Institute; Chairman of the Department of Genetics, Sterling Professor of Genetics and Internal Medicine, Director of the Yale Center for Human Genetics and Genomics, Yale School of Medicine Rathskeller open until 10:30 p.m. Program Schedule 5PROGRAM SCHEDULE Tuesday, May 19, 2009 7:45 a.m. Breakfast, Dining Room 8:45–10:15 a.m. Platform Presentations Infectious Disease, Room D-124 Cell and Developmental Biology, Room D-125 Stem Cell Biology, Auditorium 10:15–10:30 a.m. Break, Great Hall 10:30 a.m.– Noon Platform Presentations Immunology III, Room D-124 Neuroscience I, Room D-125 Genetics, Auditorium Noon Lunch, Research Scholars and Medical Fellows, Di