CHU FORT DE FRANCE NEUROCHIRURGIE - VIENNE 2011

Norberto Lucio

Description

Mots-clés: Glioblastomes,gliolan, fluorescence,sclerose en plaque,IRM.
A case of late onset multiple sclerosis mimicking glioblastoma and displaying intraoperative 5-aminolevulinic acid fluorescence
NORBERT MANZO1, ULF NESTLER1, DANIEL MEMIA-ZOLO1, NIDAL SALLOUM1, DIDIER SMADJA2, MEHDI MEJDOUBI3, ANDRE WARTER4
1CHU .FORT DE FRANCE.CARAÏBES.NEUROSURGERY, Martinique; 2CHU- FORT DE FRANCE.CARAÏBES.NEUROLOGY.; 3CHU. FORT DE FRANCE.CARAÏBES.NEURO-RADIOLOGY.; 4CHU.FORT DE FRANCE.CARAÏBES.ANATOMOPATOLOGY.
Background:
Various case reports and case series describe the resemblance of multiple sclerosis lesions to cerebral glioma on MRI. Multiple sclerosis accounts for about 1% of histological diagnosis in biopsies or surgical specimens resected for suspicion of brain tumor. Only few information is available about the interaction between sclerotic plaques and the fluorescence guided resection agent 5-aminolevulinic acid, which is currently used more and more often to allow for complete resection of malignant brain tumors.
Case description:
We report the case of a 57-year-old male patient who underwent neurosurgical intervention for an intracerebral mass lesion with the features of a malignant brain tumor on preoperative MRI. During intervention, the lesion showed strong 5-Ala fluorescence and intraoperative histological diagnosis on frozen material was malignant astrocytoma. After additional examinations on the paraffin embedded specimens definitive diagnosis revealed multiple sclerosis.
Conclusion:
We hypothesize that the inflammatory lymphatic cells engaged in the demyelinating process are susceptible to protoporphyrin IX accumulation induced by 5-aminolevulinic acid. In this way a fluorescence signal, very similar to the signal of malignant tumor cells, becomes detectable.

Informations

• Publié par: pijudo
• Publié le: 12 juin 2011
• Nombre de lectures: 568
• Langue: Français
• Poids de l'ouvrage: 7 Mo

Extrait

 

Aspects pratiques de l‘emploi de Gliolan pour la résection des gliomes

Dr. Ulf NESTLER*- Dr. MANZO Norbert.** Neurochirurgie Université Justus Liebig, Giessen, Allemagne* CHU FORT de FRANCE .Service de Neurochirurgie 6 B. FRANCE.** 97200

 

 

 

 

 

 

nécrose tumour solide zone d‘infiltration

•

•

•

 

méthodes pour achever une résection complète

ultrasonographie intraopérative

navigation neuronale

expérience du chirurgien

 

 

ultrasonographie intraopérative

 

navigation neuronale

Accumulation de fluorescence dans un gliome après administration de 5-ALA

acide laevuline 5-amino

   COO -

CH   2 CH 2 C CH 2 NH 3+   O

  illumination conventionelle  

biosynthèse d’ héme

protoporphyrine IX

M V

HC CH M NH M N N NH V P HC CH

P M

illumination d‘excitation

 

fluorophores biologiques

 

 

fluorescence