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Note that all of these doses are approximations and must be titrated to the animal’s strain, age,

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Rabbit Anesthesia/Analgesia Recommended Best Practices Note that all of these doses are approximations and must be titrated to the animal’s strain, age, sex and individual responses. Significant departures from these doses should be discussed with a veterinarian. Doses will also vary depending on what other drugs are being administered concurrently. All doses are listed as milligrams per kilogram (mg/kg) unless otherwise noted. (source UCSF) DRUG NAME DOSE (mg/kg) & FREQUENCY NOTES ROUTE Inhalation anesthetics Survival surgery should have concurrent preemptive analgesia. Must use precision 1-3% inhalant to Whenever general Recommended: vaporizer. Mask or effect (up to 5% for anesthesia is Isoflurane chamber induction induction) required without injected pre-medication may result in breath-holding and injury. Ketamine combinations May not produce surgical-plane anesthesia for major procedures. If redosing, 35 – 50 + 5-10 IM or use ketamine alone. SC (in same syringe Recommended: May be partially or with xylazine As needed Ketamine-Xylazine reversed with administered 10-20 Atipamezole or minutes in advance) Yohimbine. Note that IM Ketamine combinations often sting upon injection. May not produce surgical-plane anesthesia for major 35 - 50 + ~ 0.5 IM or procedures. If redosing, SC (in same use ketamine alone. Ketamine- syringe, or with As needed May be partially Medetomidine medetomidine reversed with administered 10-20 Atipamezole. ...
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Rabbit Anesthesia/Analgesia
Recommended Best Practices
Note that all of these doses are approximations and must be titrated to the animal’s strain, age,
sex and individual responses. Significant departures from these doses should be discussed with
a veterinarian. Doses will also vary depending on what other drugs are being administered
concurrently.
All doses are listed as milligrams per kilogram (mg/kg) unless otherwise noted. (source UCSF)
DRUG NAME DOSE (mg/kg) & FREQUENCY NOTES
ROUTE
Inhalation anesthetics
Survival surgery should
have concurrent
preemptive analgesia.
Must use precision
1-3% inhalant to Whenever general
Recommended: vaporizer. Mask or
effect (up to 5% for anesthesia is
Isoflurane chamber induction induction) required
without injected pre-
medication may result in
breath-holding and
injury.
Ketamine combinations
May not produce
surgical-plane
anesthesia for major
procedures. If redosing, 35 – 50 + 5-10 IM or
use ketamine alone. SC (in same syringe Recommended: May be partially
or with xylazine As needed Ketamine-Xylazine reversed with administered 10-20 Atipamezole or
minutes in advance) Yohimbine. Note that IM
Ketamine combinations
often sting upon
injection.
May not produce
surgical-plane
anesthesia for major 35 - 50 + ~ 0.5 IM or procedures. If redosing, SC (in same
use ketamine alone. Ketamine- syringe, or with As needed May be partially
Medetomidine medetomidine reversed with administered 10-20
Atipamezole. Note that minutes in advance) IM Ketamine
combinations often sting
upon injection.
35-40 + 3 - 5 + 0.75 May not produce Ketamine-Xylazine-
– 1.0 IM or SC (in As needed surgical-plane Acepromazine same syringe) anesthesia for major
Page 1 of 3 procedures. If redosing,
use ketamine alone.
May be partially
reversed with
Atipamezole or
Yohimbine. Note that IM
Ketamine combinations
often sting upon
injection.
May not produce
surgical-plane
anesthesia for major 35 - 50 + ~ 2 IM or procedures, but may be
Ketamine-Midazolam SC (in same As needed useful for restraint. Note syringe)
that IM Ketamine
combinations often sting
upon injection.
Reversal agents
More specific for
medetomidine than for
xylazine (as a general
Any time rule, Atipamezole is
0.1 - 1.0 medetomidine or dosed at the same
Atipamezole subcutaneous or IP xylazine has been volume as
used Medetomidine, though
they are manufactured
at different
concentrations)
For reversal of Yohimbine ~ 0.2 IV or SC xylazine effects
Other injectable anesthetics
Consider supplemental Best for
analgesia (opioid or terminal/acute Sodium pentobarbital NSAID) for invasive
20 - 60 IV; 40 IP procedures only, (Nembutal) procedures. Apnea is with booster doses
common at anesthetic as needed doses.
Opioid analgesia
Used pre- For major procedures,
operatively for require more frequent
Recommended: preemptive dosing than 12 hour
0.05 - 0.1 SC or IP Buprenorphine analgesia and post- intervals. Consider multi-
operatively every 6- modal analgesia with a
12 hour NSAID
Non-steroidal anti-inflammatory analgesia (NSAID) - Note that prolonged use my cause
renal, gastrointestinal, or other problems
Used pre- Depending on the
Recommended: operatively for procedure, may be used 4-5 SC Carprofen preemptive as sole analgesic, or as
analgesia and post- multi-modal analgesia
Page 2 of 3 operatively every with buprenorphine.
12-24 hour
Used pre-
operatively for Depending on the
preemptive procedure, may be used
0.1 – 0.3 PO, IM or Meloxicam analgesia and post- as sole analgesic, or as SC
operatively every 24 multi-modal analgesia
hour for up to 4 with buprenorphine.
days.
Used pre- Depending on the
operatively for procedure, may be used preemptive
Ketoprofen 2 – 5 SC as sole analgesic, or as analgesia and post- multi-modal analgesia
operatively every with buprenorphine. 12-24 hour
Local anesthetic/analgesics (lidocaine and bupivicaine may be combined in one syringe for
rapid onset and long duration analgesia)
Dilute to 0.5%, do Use locally before Faster onset than
Lidocaine not exceed 7 mg/kg making surgical bupivicaine but short (<1 hydrochloride total dose, SC or
incision hour) duration of action intra-incisional
Dilute to 0.25%, do Slower onset than
Use locally before not exceed 8 mg/kg lidocaine but longer (~ 4-Bupivicaine making surgical total dose, SC or 8 hour) duration of
incision intra-incisional action



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