Biologically meaningful classification of protein sequences [Elektronische Ressource] : a bioinformatic approach / von Tancred Gilles Frickey

Description

Biologically m eaningful cl assification o f pro teinsequences – a  b ioinformatic  approachder Fakultät für Biologieder E berhard Kar ls Uni versität Tü bingenzur Erlangung des G rades ei nes Doktorsder N aturwissenschaftenvonTancred Gil les Fr ickeyaus New  Yo rkvorgelegteD i s s e r  t a t i o  n2005Tag  der  mündlichen Prüfung: 20.07.2005Dekan: Prof. Dr. Friedrich Schöffl1. Berichterstatter: Prof. Dr. Andrei  Lupas2. Berichterstatter: Prof. Dr. Alfred  NordheimTable of  contents:Curriculum V itaeAbstract  (German)Introduction: 1­Aligning  two sequences 2­Finding  sequence  relatives 3­Phyl ogenetic tree construction 4­Bo otstrapping 8­Suboptim al  alignment 10 and  mutational  saturation­Evolution, lateral­gene transfer  11 and  genome  duplication­Prot ein  classification 14­Aim 16Results and  Discussion: 18­ Project  I:  PhyloGenie 18­  II:  Alignment  validation 19­ Project  III: CLANS 20­  IV: Phylogenetic analysis of AAA­proteins 21Contribution: 23Appendix: 25­BLOSUM62  substitution matrix 25­Phyl oGenie: automated  phylome  generationand  analysis.­C LANS: a Java  application for visualizing protein  families  based  on pairwise  similarity.­Phyl ogenetic analysis of AAA­proteins.Bibliography: I­III     Curriculum V itaeName: Tancred Gill es F rickey Birth: 28.08.74 in New  Y orkAddress: Vöchtingstr. 0 972076 Tu ebingen, G ermanyTelephone: [phone] ( work)Father: Franklin William F rickey ( 09.

Sujets

• Biologie

Informations

• Publié par: eberhard_karls_universitat_tubingen
• Publié le: 01 janvier 2005
• Nombre de lectures: 7
• Langue: English
• Poids de l'ouvrage: 6 Mo

Extrait

Biologically meaningful classification of protein sequences – a bioinformatic approach

der Fakultät für Biologie der Eberhard Karls Universität Tübingen

zur Erlangung des Grades eines Doktors der Naturwissenschaften

von

Tancred Gilles Frickey aus New York

vorgelegte D i s s e r t a t i o n 2005

Tag der mündlichen Prüfung:

Dekan:

1. Berichterstatter:

2. Berichterstatter:

20.07.2005

Prof. Dr. Friedrich Schöffl

Prof. Dr. Andrei Lupas

Prof. Dr. Alfred Nordheim

Table of contents: Curriculum Vitae Abstract (German) Introduction: -Aligning two sequences -Finding sequence relatives -Phylogenetic tree construction -Bootstrapping -Suboptimal alignment and mutational saturation -Evolution, lateral-gene transfer and genome duplication -Protein classification -Aim Results and Discussion: - Project I: PhyloGenie - Project II: Alignment validation - Project III: CLANS - Project IV: Phylogenetic analysis of AAA-proteins Contribution: Appendix: -BLOSUM62 substitution matrix -PhyloGenie: automated phylome generation and analysis. -CLANS: a Java application for visualizing protein families based on pairwise similarity. -Phylogenetic analysis of AAA-proteins. Bibliography:

1 2 3 4 8 10 11 14 16 18 18 19 20 21 23 25 25

I-III

 Curriculum Vitae Name: Tancred Gilles Frickey Birth: 28.08.74 in New York Address: Vöchtingstr. 09 72076 Tuebingen, Germany Telephone: [phone] (work)

Father: Franklin William Frickey (09.07.42) Mother: Genevieve Marie Frickey (11.01.43)

Personal: Unmarried US and French nationality Languages: German (fluent), English (fluent), French (fluent) Computer skills: Languages: Java, Perl, HTML OS: Windows95/98/2000/NT4, Solaris, Linux

Education: 2001-2005 Ph.D. student: Max-Planck Institute for Developmental Biology, Tübingen “Biologically meaningful classification of protein sequences – a bioinformatic approach.” 2001 Diploma: Biology, Constance University “Dealing with mutational saturation at the amino acid level” 1996-2001 Biology, Constance University WS 1995 Cybernetics, Stuttgart University 06.1994 (Baccalaureat) Abitur Kaiserin-Friedrich-Gymnasium Majors: English, Chemistry 1985-94 Kaiserin-Friedrich-Gymnasium 1981-85 Grundschule Ober-Erlenbach

Professional experience: 10.2001-present Ph.D. student: MPI for Developmental Biology SS 1997-WS 2001 Student assistant in the Workgroup Meyer Evolutionary Biology, Constance University 08.07.96-04.08.96 Practical at Sanitätshaus Reininger Construction of Prosthetics-, Orthetics 01.06.96-01.07.96 Practical at the architectural design firm Barsties 10.07.95-04.08.95 Practical at ITT Automotive Europe Gmbh (Lathe, milling machine) 04.10.94-10.07.95 National service (France)

Other interests:

Climbing, Swimming, Sculpture, Juggling, Goldsmithying, CAD, Programming.