Delay in pathological tissue processing time vs. mortality in oral cancer: Short communication

Jerjes Waseem, Upile Tahwinder, Radhi Hani, Petrie Aviva, Adams Aidan, Callear Jacqueline, Kafas Panagiotis, Hopper, Hopper Colin

Description

Several factors have been identified to affect morbidity and mortality in oral cancer patients. The time taken to process a resected cancer specimen in a patient presenting with primary or recurrent disease can be of interest as delay can affect earlier interventions post-surgery. We looked at this variable in a group of 168 consecutive oral cancer patients and assessed its relationship to mortality from the disease at 3 and 5 years. It is expected that delay in pathological processing time of surgical specimens acquired from patients with recurrent disease may increase or contribute to the increased rate of mortality. Further high evidence-based studies are required to confirm this.

Informations

• Publié par: biomed
• Publié le: 01 janvier 2012
• Nombre de lectures: 5
• Langue: English
• Poids de l'ouvrage: 1 Mo

Extrait

Jerjeset al. Head & Neck Oncology2012,4:14 http://www.headandneckoncology.org/content/4/1/14

R E S E A R C HOpen Access Delay in pathological tissue processing time vs. mortality in oral cancer: Short communication 1,2,3,4* 5,62 74 4 Waseem Jerjes, Tahwinder Upile, Hani Radhi , Aviva Petrie , Aidan Adams , Jacqueline Callear , 8 3,6 Panagiotis Kafasand Colin Hopper

Abstract Several factors have been identified to affect morbidity and mortality in oral cancer patients. The time taken to process a resected cancer specimen in a patient presenting with primary or recurrent disease can be of interest as delay can affect earlier interventions postsurgery. We looked at this variable in a group of 168 consecutive oral cancer patients and assessed its relationship to mortality from the disease at 3 and 5 years. It is expected that delay in pathological processing time of surgical specimens acquired from patients with recurrent disease may increase or contribute to the increased rate of mortality. Further high evidencebased studies are required to confirm this.

Introduction The incidence of oral squamous cell carcinoma (OSCC) remains high. Oral and oropharyngeal carcinomas are the sixth most common cancer in the world. Numerous clinicopathological parameters have been implicated in prognosis, recurrence and survival, following this unfor giving disease [1,2]. The correct identification of pathology is essential to the correct treatment. Unfortunately due to the nature of replicative diseases, as in malignancy, tumour doubling time becomes an issue. Even small delays in applying fur ther interventions may allow further tumour invasion and infiltration of the locoregional surroundings resulting in a previously resectable growth becoming unresectable or unmanageable with the current chemoradiotherapeutic protocols [1,2]. Pathological processing time is identified as the time taken from acquiring the resected tumour specimen by the surgeon to the reporting of the results by the histo pathologist. The report will usually include grading and pathological staging of the tumour, the state of the surgi cal margins and any invasion to neurovascular or hard tissue structures. It has been known that histopathological processing can take few days but this might increase if it involves composite specimen (i.e. hard tissue). Also the use of

* Correspondence: [e-mail] 1 Department of Surgery, Dijla University College, Baghdad, Iraq 2 Oral and Maxillofacial Surgery Unit, ALMustansirya University, Baghdad, Iraq Full list of author information is available at the end of the article

special testing can increase the time of processing. Over the last few years an increase in the workload on path ology departments has lead to further delay in patho logical processing time [1]. The overall effects of delays in pathological processing time are unknown. In this short communication, we reviewed time intervals between taking the surgical spe cimen and definitive pathology report in patients with primary or recurrent disease. In each case we correlated this to 3 and 5year survival rates.

Materials and methods This retrospective analytic study looked at 168 consecu tive oral cancer patients who presented to University College London Hospital over a 10year period (1992– 2002). All patients suffered from recurrent disease. Pro formas were created to collect the clinicopathological data and validated by a sample review. Pathological processing time of the resected specimen was identified.“Duration 1”refers to the time (in days) taken to process and report on the resected tissue of the primary tumour. While“Duration 2”refers to the time (in days) taken to process and report on the resected tis sue of the recurrent disease.

Statistical analysis The outcomes of the categorical clinicopathological vari ables were summarised as frequencies and percentages for the whole group of patients and for the recurrence

© 2012 Jerjes et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.