Detection of glutamate in vivo in the human brain using 2D zero-quantum coherence _1hn1H NMR spectroscopy at 3 Tesla [Elektronische Ressource] / put forward by Sarah Rebecca Snyder

Sujets

• Gesundheit

Informations

• Publié par: ruprecht-karls-universitat_heidelberg
• Publié le: 01 janvier 2009
• Nombre de lectures: 7
• Langue: English
• Poids de l'ouvrage: 372 Mo

Extrait

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ofsubmittedin:toDiplom-Phtheexamination:ComforwbinedeccaFennsylvacultieser,forSciencesthebNaturalSarahSciencesyderandork,forUSAMathematicsofofctortheNaturalRupPuterto-CarolaardUnivyersitysicistyRebofSnHeidelbBornerg,YGermanPyania,forOralthe15DissertationdegreeOctobof2009Do1
ChristophofProf.Glutamate3InBacVivorineslathePHumanDr.Brainmusingat2DTZero-QuanReferees:tumDr.CoherenceeterDetectionhertProf.HDr.NMRCreSpeectroscopy1
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STEAMof.Figures.andSTEAMTolutionables.ix.1.In.troctraduction.3.1.1.One-dimensional.vii.H29NMR.Sp.ectroscop.y........14.............Spins.ectroscop.....the.....The3.1.2ShiftT.w.o-dimensional.UnitsCouplingH.NMR.Sp.ectroscopMRSy......2.3.1.................Ev.2D.olution.the......3.1.3Magnetization2D.and.H32MRSeof.Glutamate.viawSTEZQC-2D....2.2.1...............2.2.2............4.1.4LoList2D.ols.H.MRS.of.Glutamate.via.undersampled.STEZQC-2D................195.2.Nuclear.Magnetic.Resonance,.Magnetic.Resonance.Sp.ectroscop3yof,1-andectroscopDetectionMagnetization91D2.1wibPRESSH.NMR..............29.olution.Sequence...STEAM.....Magnetization.2D.y.......41.of.Sp.......42.14.Chemical..............9.2.1.1.Sym.H.N.MR....14.Scalar.............................2.3.calized.H......................10.2.1.2.v.H.NM19RPRESS.................................2.3.2............................10.2.1.3.Abbreviations21HMagnetizationNMRolution.J-Coupled.in.and.Sp.y.3.1.Ev.in.Sp.y.th.Sequences.and...................................3.1.111Ev2.2inContentsPRESS....3.1.2.Evin.H30MRSMagnetization.olution.the.Sequence.........3.2.Ev.in.Sp.ctroscop.................3.2.1.Creation.T.o-dimensional.e...............i.1
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F.of.102.........7.2.2.....Vivo...del.81................42.4BibliographGlutamateResultsand.Glutami.nedelanddelthe.STEZQC-2D.Sequence.47.4.1.TheGlxRole.ofSolutionGlutamate.and.Glutamine.in.the.Brain....ariation.....with.TE.a........47te4.2.The82H.Sp.ectroscop.ySolutionsof.Glutamate.andComparisonGlutamiandne......98.......7.3.1.......Mo......49F5.Materials.59.5.1.Hardw.are..............Discussion.133.Com.STEZQC-2D.77.7.1.er.................Individual.Glutamine.......Glutamate.............Mo..59.5.2.Mo.del.Solutions90andZQCVofolun.teers..............Brain.del.............Mo.............7.3.260Solution5.3.Soft.w.are......Undersampling.Shift...........7.5...................7.6.TE...............114.Publications.127.ts.Optimal.binations.TE62andSequence.6.Metho7ds8167W6.1tTheoreticalMoEv.aluation.of.the.ZQC.of.the.3.2.2...CH.using.the.Pro.duct.Op.er-.ator.F7.2ormalismGlutama.and.Mo.Solutions...........7.2.1.Mo.Solutions.....................82.Glutamine.del................67.6.2.In.Vitr7.2.3oofMeasuremenResonancetsrequenciesvGlutamatearyingGlutamineTM..............................7.3.and.Mo.Solutions....75.6.2.1.A.cc.o.r.di.ng.to.the100NyquistBrainTheoremdel.........................100.Glx.del....75.6.2.2.Undersampling.and.F.ourier.Shift..........7.4.and.ourier......................761056.3InIn.Vivo..................................110.V.of.................................8761216.4125InyVitrGratitudeoiiMeasuremeniiiiv