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Extracellular Stimulation of
Individual Electrogenic Cells with
Micro-Scaled Electrodes
Von der Fakultat fur Elektrotechnik und Informationstechnik
der Rheinisch-Westfalischen Technischen Hochschule Aachen
zur Erlangung des akademischen Grades eines Doktors
der Ingenieurwissenschaften genehmigte Dissertation
vorgelegt von
Stefan Eick
aus Monchengladbach
Berichter: Universitatsprofessor Dr.rer.nat A. O enh ausser
Universitatsprofessor Dr.rer.nat W. Mokwa
Tag der mundlichen Prufung: 7. Januar 2010
Diese Dissertation ist auf den Internetseiten der Hochschulbibliothek online verfugbar.There’s no thrill in easy sailing when the skies are clear and blue,
there’s no joy in merely doing things which anyone can do.
But there is some satisfaction that is mighty sweet to take,
when you reach a destination that you never thought you’d make. . .
author unknownAbstract
The interface between biological and electronic information processing within bioelectronic
hybrid systems is an exciting eld of research. From an application point of view, it o ers
the possibility to develop and improve neuroprosthetic devices, e.g. for medical use. In
basic neuroscience it enables the investigation of dissociated neuronal cultures or brain slices
to elucidate the development, plasticity, and information processing of neuronal networks.
To this end, systems and devices for stable long-term investigations with multiple interfaces
for extracellular recording and stimulation on a single-cell level are desirable to gain precise
access to the network or tissue. The main focus of this work was to study the extracellular
stimulation of individual electrogenic cells in vitro with surface-embedded microelectrodes.
For this purpose, a new electrophysiological system, including devices and a versatile and
customizable amplier, was developed. The novel amplier is comprised of a general main
amplier for impedimetric and electrophysiological experiments and multiple headstages
specialized for individual chip types including multi-electrode arrays (MEAs) and integrated
chips combining stimulation electrodes and recording eld-e ect transistors. The ampli

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