Comment 141 ALL

Jo Fishenden

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COMMENTTHE COLLEGE NEWSLETTER ISSUE NO 141 | MAY 2002Enzyme aidsspinal cordregenerationrial enzyme called chondroiti-ecent research by scientistsnase ABC destroys some of theat King’s Centre formolecules in the scar, allowingRNeuroscience Research maynerves a path to grow back along. pave the way for new treatmentsDr Elizabeth Bradbury, leadof spinal cord injuries.author and researcher in theSpinal cord injuries typicallyGuy’s, King’s & St Thomas’arise from car accidents, violence,School of Biomedical Sciences,falls and sports injuries, with ansaid: ‘The enzyme may becomeaverage of two new cases admit-part of a developing arsenal ofted every day in the UK alone.therapies to treat people suffer-In research published lasting from paralysing injuries. month in Nature and supported‘After damage to spinal cordby the Wellcome Trust, scientiststissue, a complex jungle of mole-from the Centre show how ancules is deposited in the scarredarea. Chondroitinase ABC actslike a “molecular machete” cut-Clinical trials involving thisting a path through the jungle of Stem cell licencetreatment as part of a multi-molecules that usually preventtargeted therapy could startspinal cord nerves growing back Professor Peter Braude and Dr Stephen Minger, together with Dr Susanwithin the next five years.Pickering were granted one of the first two UK licences by the Humaninto these damaged areas.Fertilisation and Embryology Authority to produce human ...

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• Publié par: Zazak
• Nombre de lectures: 34
• Langue: English

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miracle cure. There are still many other blocks that must be overcome before complete spinal cord repair can be achieved in humans. In terms of treating people, we could see clinical trials involving this treatment as part of a multi- targeted therapy starting within the next five years.’

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News

Left: Pr ofessorful eye of dental Nairn Wilson, students andD   r Head of Guy’s,Pat Reynolds, King’s & Senior Lecturer St Thomas’ and member of Dental Institute, the team that launches the new helped develop dental website the site under the watch-

o T f h  t e h  d e  e S v t e   l T o h p o m m e a n s t ’   New dental campus website A t t   m h t e h er d e  e i t a   i   m s w p e a   e o s c   f u  g l c a o o t i i n n o s g n i     t d o o e   n r p   a r t e b h l ss e e launched King’s & St Thomas’ Dental f T u h tu o r m e  as o ’  f  ca B m lo p c u k s   .  9 T   h o e n     C t o h l e l   eg S e t A t th ti e t   u e t n e  d l   a o u f  n M ch ar e c d h   , a     G n u e y w ’s, from buying the course throughIns is working closely with Guy’s website that will help all qualifietdo taking the lectures and then and St.Thomas’ NHS Trust on dentists to study and improve the online test at the end. a plan to develop the building, their skills, without having to ‘Our online CPD courses mean currently underused, as an take time out of their practices. dentists can access top quality academic/health centre. The At the beginning of this year itteaching at their own conven- College has also received an became a legal requirement for ience. It’s particularly gratifying to unsolicited offer from the Aga UK dentists to keep their knowl- know that theprofits from this Khan Development Network edge and skills up-to-date througvhenture, unlike those of commer- to develop the site as a library lifelong learning, or ‘continuouscial companiesoefrfing CPD, will and museum. A final decision professional development’ go right baciknto the Dental on the future of the site will be (CPD). Many existing coursesInstitute, directlbyenefiting dental made by the College Council demand time away from the sur-education and the dentists of in due course. gery, whichcan mean postponed tomorrow,’ Professor Nairn patient appointments and a loss Wilson, Head of thDeental of income. TheDental Institute Institutecommented. The website courses are entilryeweb-based, address is www.gkt-cpd.org

Skin disease genetic discoveryUrology meeting A s b D t y u e   d t r h y m   e a p   t S u o t l b   o l J i o g s y h h   n e a ’ d s t       i I n n K   s i A t n i p g t ’ r u s i   l t   e l h   e a o d s f   s e c r r y ‘ e   T e t h n h i   s a f   t a   is m   m il a i a n e k   s e i  t s m   o  p i s t o e   r e t p   a i o n f  s t t s   i h d b e i l s y e c     a o r t v e o - i o e n p x t c e o i   n ti s a   n l g t n   e e r b w n e   a c t a i a v v u e e s n   e u   tr e t e s h   a e t o   f m   d e r i e s n c s ts e o   a v r e f c r o h y r K i o E n f u   g t r ’s h o   e p w   e F a a i s r n   s   c t s   o I a - n t h t e o e ll s r it t n   e a   o t f i m   o t e n h e a e t l ing shown how mutations in a gene carriers of the disease and to skin ageing, scarring or poor Radical Prostatectomy Summit at Denmark Hill in March. The lead to the development of wound healing,’ John McGrath, College co-ordinator was Peter s l l i i k e p i s o n   i   d d   t i h p s r r o o o r t d u e e g i r h n   o o t s h u i t a s   , t     a a t f n h f   e e i   c n ts h   w e f r o a i r t m l e d i d - . Identifying the gene abnormality s t P a o r i l o d o f . g   e y ‘ s ,  s W o w e r h    t o o h   f i h   n e M k a   d o t e l h e d e c     t u h p la r e r o     r t e e D s i e e a r r m ch a , - U Bi n s it h  i a n i,     th m e a   n D a e g p e ar r  t o m f  e t n h t e     o A f CCESS in lipoid proteinosis is a greatn this Surgery. achievement.gene produces may be involved d L m i e o p r s s o t   i   i c d n   o  S p m r o o m u t t e o h i n   n   A s o f i s r n i i s c g   l a i , e s       w g o i e n t n e h e       d o d i f  s is f t i o h g r e -in a wide range of roles, perhaps wit T h h   e a     m si e st e e ti r  n p g r   o ra gr n  a in m  p m a e r   a b ll e e i l ng - acting as some sort of biological conducted at the Cleveland glue that holds other skinuring symptoms that begin in research new forms of treatment  proteins together. We hope to Clinic, Ohio and delegates were childhood. for affected people. It is also  develop studies to determine if kept in touch via a high-resolu- it might be useful in preventing l t i i v o e n     li tr n a k  n e s n at a l b a l n e t d ic     d I e S l D eg N  a l t in es k   . i  T n his wrinkles or acting as some sort of the UK to watch operations con- ‘internal sunscreen’ to prevent ducted in the US, as well as the ageing effects of sunlight on interacting with their American the skin. However, for now just identifying the gene abnormality colleagues in sessions. in lipoid proteinosis is a great Technical and theoretical achievement. a p s ro p s e t c a t t s e  o c f t   o te m c y h   n w i e q r u e e   s c   o o v f  e r r a e d d i , c   a a l s ’ Left:The demonstrating well as the issues behind forehead of a the marked wrin- patient selection and post-oper- South African kling of the ative management. The meeting patient with lipoid forehead proteinosis was attended by doctors from all over Europe and Asia.

2 | COMMENT | May  2002