Routes of intake and implementation of pharmacodynamic models

European Union

Description

Medical and biological research

Sujets

• Pharmacology
• Médecine

Informations

• Publié par: EUROPEAN-UNION
• Nombre de lectures: 142
• Langue: English
• Poids de l'ouvrage: 6 Mo

Extrait

Pharmacodynamic
Models
Ol
Selected Toxic
Chemicals in Man
Routes of Intake and Implementation
of Pharmacodynamic Models
0%
by
A. D. Smith and M. C. Thome
Volume 2
MTP Press for the Commission of the European Communities Pharmacodynamic Models
of Selected Toxic
Chemicals in Man
Volume 2: Routes of Intake and Implementation
of Pharmacodynamic Models Pharmacodynamic Models
of Selected Toxic
Chemicals in Man
Volume 2: Routes of Intake and Implementation
of Pharmacodynamic Models
Prepared for the
Directorate­General of Employment,
Social Affairs and Education
of the Commission of the European Communities
by
A. D. Smith and M. G Thorne
Associated Nuclear Services
60 East Street, Epsom, Surrey, England
«SÇK MTP PRESS LIMITED U
—4>νΓ# a member of the KLUWER ACADEMIC PUBLISHERS GROUP Hfil
LANCASTER / BOSTON / THE HAGUE / DORDRECHT P™
forthe Commission ofthe European Cor imunities.irjo, ρ p.... ,
t Ν.CVLoTi /O Η Oj
CL Published ¡η the UK and Europe by
MTP Press Limited
Falcon House
Lancaster. England
British Library Cataloguing in Publication Data
Smith, A. D.
Pharmacodynamic models of selected toxic
chemicals in man.
1. Toxicology—Methodology
2. Chemicals—Physiological effect
3. Pharmacokinetics
I. Title II. Thome, M. C.
615.9Ό7 RA1199
ISBN 0­85200­953­4 v. 2
Published in the USA by
MTP Press
A division of Kluwer Boston Inc.
101 Philip Drive
Norwell, MA 02061. USA
Library of Congress Cataloging­in­Publication Data
Thorne, M. C.
Pharmacodynamic models of selected toxic
chemicals in man.
(ANS report; no. 512­2)
Includes bibliographies and index.
Contents: v. 1. Review of metabolic data—
v. 2. Routes of intake and implementation of
pharmacodynamic models/A. D. Smith and M. C. Thorne.
1. Carcinogens—Metabolism. 2. Pharmacokinetics.
3. Carcinogens—Metabolism—Mathematical models.
1. Jackson, D. II. Smith, A. D. (Anthony David)
III. Title. IV. Series. [DNLM: 1. Models, Chemical.
2. Poisons—pharmacodynamics. QV600 T511p]
RC268.6.S65 1986 616.99'4071 86­124
ISBN 0­85200­952­6 (v. 1)
ISBN 0­85200­953­4 (v. 2)
©ECSC. EEC, EAEC, Brussels and Luxembourg, 1986
EUR 10409
Legal Notice
Neither the Commission of the European Communities nor any person acting on behalf of the
Commission is responsible for the use which might be made of the following information.
Publication arranged by
Commission of the European Communities
Directorate­General Telecommunications,
Information Industries and Innovation,
Luxembourg
All rights reserved. No part of this publication may be reproduced,
stored in a retrieval system, or transmitted in any form or by any
means, electronic, mechanical, photocopying, recording or otherwise,
without prior permission from the publishers.
Printed and Bound by Butler & Tanner Limited, Frame and London Contents
1 FOREWORD v¡¡
2 SUMMARY viii
3 INTRODUCTION ix
4 REVIEW OF RECENT LITERATURE
4.1 Arsenic 1
4.2 Beryllium 16
4.3 Cadmium 2
4.4 Lead 40
4.5 Nickel 51
4.6 Chromium5
4.7 Asbestos 6
4.8 Benzene3
4.9 Vinyl chloride7
4.10 Benzidine 72
4.11 Carbon tetrachloride8
4.12 Methyl iodide 8
4.13 References
5 MODEL OF Gl TRACT
5.1 Introduction 106
5.2 Physiology and anatomy of the Gl tract 10
5.3 Gastrointestinal transit 120
5.4 Absorption and retention of material by the intestinal wall 129
5.5 Modelling retention in the gastrointestinal tract 131
5.6 References 132
6 MODELLING THE DEPOSITION AND RETENTION OF PARTICULATE
MATERIALS IN THE LUNG
6.1 Introduction7
6.2 The anatomy and physiology of the respiratory tract 138
6.3 Deposition 156.4 Clearance 210
6.5 Model structure242
6.6References246
7METHODOFCALCULATION
7.1Generaldescription of the model270
7.2Thecomputer code MOSAIC273
7.3Ther code GRAPH291
7.4References291
8IMPLICATIONSOF DIFFERENT REGIONS OF EXPOSURE
8.1 Description of the exposure regimes 293
8.2 Discussion of results295
8.3 References · 299
9CONCLUSIONSAND RECOMMENDATIONS300
10ACKNOWLEDGEMENTS302
APPENDICES
A Computer programs for evaluating the implications of
different exposure regions 303
Β Graphicaloutputofsimulations of the model 351
vi