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New fluorescent labels and probes for biological applications [Elektronische Ressource] / vorgelegt von Martin Link

116 pages
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Univ
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des
und
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der
der
ersit?t

v
haften
v
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rer.
aus
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an
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eit
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en
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egener
f?r
J.

h
he
h
Chemie,
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Chemo-
2010
und
ollo
Biosensorik
16.April
der

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uss:
ersit?t
orsitzender:
Regensburg.
Dr.
Die
Brunner
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h
eit
Prof.
wurde
O.
angeleitet
W
v
eis
on
eitgutac
Prof.
ter:
Dr.
Dr.
Otto
W
S.
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Dr.
olfb
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eis.steht
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and
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h
their
and
and
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ery
memKatja
f?r2.3.4
Con
NIR-lab
ten
.
ts
.
1
.
In
Prop
tro
.

.
1
.
1.1
.
Ov
.
erview
lab
.
19
.
.
.
.
.
.
.
.
.
.
.
of
.
16
.
.
.
.
.
.
.
.
.
.
.
as
.
.
.
.
.
erties
.
.
.
el
.
.
.
.
.
29
.
.
.
els
.
.
.
.
.
.
.
.
.
2.3.9
.
.
.
18
.
.
.
.
1
.
1.2
.
Motiv
37
ation
.
and
.
Aim
es
of
.
W
.
ork
of
.
.
.
.
.
.
.
9
.
.
.
.
.
2.3.3
.
.
.
.
.
.
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els
.
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.
.
.
of
.
.
.
.
.
2.3.6
.
.
.
.
.
.
.
.
.
.
2
.
2
erties
New
.
Fluorescen
.
t
.
Lab
el
els
.
3
.
2.1
Preparation

.
kground
.
.
.
.
el
.
.
.
.
.
37
.
.
.
.
.
.
.
ev
.
.
.
38
.
.
.
.
.
Deriv
.
pheno
.
els
.
.
.
.
.
.
.
2.3.1
.
el
.
.
.
.
.
.
.
.
.
.
.
2.3.2
.
lab
.
.
.
.
.
.
3
.
2.1.1
.

.
lab
of
eling
.

.
hnologies
.
.
.
.
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.
of
.
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.
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Prop
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els
.
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.
.
.
.
.
.
.
.
of
5
.
2.1.2
.

.
k
.
Chemistry"
.
as
2.3.7
new
el
lab
.
eling
.

.
hnology
.
.
.
.
2.3.8
.
lab
.
.
.
.
.
.
.
.
.
.
7
.
2.2
of
Deriv
.
ativ
.
es
.
of
.
1,8-Naph
.
thalimide
35
as
lab
VIS-lab
.
els
.
.
.
.
.
.
.
.
36
.
of
.
.
.
.
.
.
.
.
.
.
.
.
.
Application
8
18
2.2.1
.
Preparation
.
of
.
lab
.
el
.
2
Summary
.
of
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
2.3
.
ativ
.
of
.
xazines
.
NIR-Lab
.
.
.
.
.
.
.
.
.
.
.
.
.
.
9
21
2.2.2
Preparation
Prop
lab
erties
9
of
.
lab
.
el
.
2
.
.
.
.
.
.
.
.
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23
.
Prop
.
of
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.
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.
.
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24
10
Applications
2.2.3
lab
Applications
9
of
.
lab
.
el
.
2
.
.
.
.
.
.
.
.
.
.
.
.
.
.
25
.
Preparation
.
lab
.
14a/b
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
2.3.5
.
erties
11
lab
2.2.4
14a/b
Preparation
.
of
.
lab
.
el
.
5
.
.
.
.
.
.
.
.
.
.
30
.
Applications
.
lab
.
14a
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
32
.
Preparation
.
lab
.
16
15
.
2.2.5
.
Prop
.
erties
.
of
.
lab
.
el
.
5
.
.
.
.
.
.
34
.
Prop
.
of
.
el
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
35
.
Applications
.
lab
.
16
.
.
17
.
2.2.6
.
Applications
.
of
.
lab
.
el
.
5
.
.
.
.
.
.
2.3.10
.
of
.
el
.
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.
.
.
.
.
.
.
.
.
.
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.
.
.
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.
.
.
2.3.11
.
erties
.
lab
.
18
.
.
17
.
2.2.7
.
Comp
.
ound
.
4
.
in
.
a
.
sensor
.
for
.
o
.
xygen
2.3.12
.
of
.
el
.
.
.
.
.
.
.
.
.
.
.
.
.
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.
.
.
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.
.
.
2.3.13
19
and
2.2.8
aluation
Summary
the
and
els
ev
.
aluation
.
of
.
the
.
VIS-lab
.
els
i
.2 2
2 2
.
and
lab
thiol-lab
.
els
.
based
.
on
14a/b
purple
.
and
.
blue

pheno
68
xazines
.
.
.
.
with
.
.
41
4.2.19
3
.
New
.

lab
t
5
PET-prob
69
es
4.2.8
for
separation
H
.
Azido-
el
O
.
2.4
.
sensing
81
42
21
3.1
of

.
kground
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.
.
.
with
.
.
.
.
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.
Lab
.
.
.
exp
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el
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eling
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lab
.
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.
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.
4.2.18
.
.
.
.
.
.
.
Syn
.
.
42
.
3.1.1
.
Dev
eling
elopmen
.
t
.
and
4.2.3
application
erimen
of
4.2.4
PET-prob
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es
.
.
.
.
ts
.
.
.
.
.
5-analyte
.
.
.
of
.
.
.
.
44
.
3.1.2
erimen
PET-prob
.
es
.
for
el
h
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ydrogen
thesis
p
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ero
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xide
.
sensing
with
.
.
.
.
.
separation
.
4.2.13
.
.
.
.
.
.
.
eling
.
.
.
.
45
Syn
3.1.3
.
Preparation
.
of
.
prob
exp
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.
21
.
.
thesis
.
.
.
.
.
.
.
t
.
to
.
.
.
prob
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.
.
.
.
.
.
62
.
of
.
.
.
.
.
.
.
.
.
.
.
.
.
4.2.2
48
erimen
3.1.4
el
Prop
.
erties
.
of
.
prob
.
e
el
21
separation
.
.
.
.
.
thesis
.
.
.
.
.
.
.
.
.
.
.
66
.
exp
.
lab
.
.
.
.
.
.
.
.
.
Lab
.
in
.
ts
.
.
.
Syn
.
el
49
.
3.1.5
.
Applications
.
of
.
prob
.
e
.
21
eling
.
with
.
.
.
.
.
.
.
.
.
4.2.9
.

.
erimen
.
.
.
4.2.10
.
lab
.
.
.
.
.
.
.
.
.
.
.
4.2.11
.
erimen
.
el
.
.
50
.
3.1.6
.
Preparation
4.2.12
of

prob
erimen
e
.
26
thesis
.
16
.
.
.
.
.
.
.
.
.
.
.
4.2.14
.
erimen
.
el
.
.
.
.
.
.
.
80
.
of
.
.
.
.
.
.
.
.
.
.
.
.
53
Lab
3.1.7
ts
Prop
18
erties
.
of
.
prob
.
e
4.2.17
26
prob
.
.
.
.
.
.
.
.
.
.
.
.
.
v
.
hmen
.
e
.
.
.
.
.
.
.
thesis
.
26
.
.
.
.
.
.
.
.
.
.
.
.
.
.
54
4.2.1
3.1.8
thesis
Applications
lab
of
2
prob
.
e
.
26
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
62
.
Lab
.
exp
.
ts
.
lab
.
2
.
.
.
.
.
.
.
.
.
.
.
.
55
.
3.1.9
64
Summary
Lab
and
2-analyte
ev
in
aluation
exp
of
ts
the
.
H
.
ii
65
O
Syn
CONTENTS
of
5
el
.
.
prob
.
es
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
56
4.2.5
4
eling
Exp
erimen
erimen
with
tal
el
P
.
art
.
59
.
4.1
.
General
.
Remarks
.
.
.
.
.
.
4.2.6
.
el
.

.
separation
.
erimen
.
.
.
.
.
.
.
4.2.7
.
thesis
.
lab
.
9
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
69
.
Lab
.
exp
59
ts
4.1.1
lab
Reagen
9
ts
.
and
.
Buers
.
.
.
.
.
.
.
.
.
.
72
.
Lab
.
9-analyte
.
in
.
exp
.
ts
.
.
.
.
.
73
.
Syn
.
of
.
els
.
.
.
.
.
.
.
.
.
.
.
.
59
.
4.1.2
.
Chromatograph
.
y
.
.
74
.
Lab
.
exp
.
ts
.
lab
.
14a
.
.
.
.
.
.
.
.
.
.
.
.
.
79
.
Lab
.
14a-analyte
.
in
.
exp
.
ts
.
.
.
79
.
Syn
.
of
.
els
.
.
60
.
4.1.3
.
Sp
.

.
y
.
.
.
.
.
.
.
.
.
.
.
.
79
.
Lab
.
exp
.
ts
.
lab
.
16
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
4.2.15
.
thesis
.
lab
.
18
.
.
.
.
.
.
.
.
61
.
4.1.4
.
Determination
.
of
.
the
.
molar
.
absorption
.

4.2.16

eling
ts
erimen
and
with
quan
el
tum
.
yields
.
.
.
.
.
.
.
.
.
.
.
.
82
.
Syn
.
of
.
e
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
83
.
Co
.
alen
61

4.2
t
Syn
prob
thesis
21
and

Application
.
.
.
.
.
.
.
.
86
.
Syn
.
of
.
e
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
87
.2 2
.
4.2.20
5.2
Exp
Curriculum
erimen
.
tal
.
pro
98

.
for
.
H
.
iii
.
O
Publications
CONTENTS
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.
e
.
.
.
.
.
.
.
.
.
.
95
91
97
5
Presen
Summary
100
94
.
5.1
.
Summary
94
in
Summary
English
German
.
.
.
.
.
.
.
.
.
.
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.
.
.
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.
.
6
.
vitae
.
7
.
and
.
tations
.
References
.

λex
λ λ λem ex em
een
y
another
ears
ectral

Ov

near
has
parts
b
the
ecome
In
an
[11].
imp
and
ortan
kground
t
the
and
laser
p
hloride
o
with
w-
its
erful
els
analytical
has
to
op
ol
v
whic
visible
h

is
etts,
rmly

established
the
in
stable
man
sp
y
erview
areas
510
of
7])
the
Chapter
scien
ha
tic
used
w
and
orld,
y
esp
in
ecially
es
in
w
biology
are
and
ertaining

the
It
sp
is
y
widely
or
used
t
in
tly
imm
of
unoassa
in
ys,
this
la-
e
b
inexp
eling
[12].
of
t
biomolecules
Dansyl
with
er
prob
340
es,


after
t
amine
sensors
(
for
493
pH
particular
and
ativ
ions,
e
and
tensiv
other
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