Common Statistical Methods for Clinical Research with SAS Examples, Third Edition

Glenn Walker, Jack Shostak

Description

Glenn Walker and Jack Shostak's Common Statistical Methods for Clinical Research with SAS Examples, Third Edition, is a thoroughly updated edition of the popular introductory statistics book for clinical researchers. This new edition has been extensively updated to include the use of ODS graphics in numerous examples as well as a new emphasis on PROC MIXED. Straightforward and easy to use as either a text or a reference, the book is full of practical examples from clinical research to illustrate both statistical and SAS methodology. Each example is worked out completely, step by step, from the raw data.
Common Statistical Methods for Clinical Research with SAS Examples, Third Edition, is an applications book with minimal theory. Each section begins with an overview helpful to nonstatisticians and then drills down into details that will be valuable to statistical analysts and programmers. Further details, as well as bonus information and a guide to further reading, are presented in the extensive appendices. This text is a one-source guide for statisticians that documents the use of the tests used most often in clinical research, with assumptions, details, and some tricks--all in one place.
This book is part of the SAS Press program.

Sujets

• Medical statistics
• Health care
• Clinical trial
• Pharmaceutical drug

Informations

• Publié par: SAS Institute
• Date de parution: 15 février 2010
• Nombre de lectures: 0
• EAN13: 9781629590318
• Langue: English
• Poids de l'ouvrage: 4 Mo

Extrait

The correct bibliographic citation for this manual is as follows: Walker, Glenn A., and Jack Shostak. 2010.
®Common Statistical Methods for Clinical Research with SAS Examples, Third Edition. Cary, NC: SAS Institute Inc.
®
Common Statistical Methods for Clinical Research with SAS Examples, Third Edition
Copyright © 2010, SAS Institute Inc., Cary, NC, USA
ISBN 978-1-60764-228-2
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CONTENTS



Preface to the Third Edition .............................................................................. ix
Preface to the Second Edition ............................................................................................. xi
Preface to the First Edition .................................................................................................xiii

Chapter 1 – Introduction & Basics
1.1 Statistics—the Field .................................................................................. 1
1.2 Probability Distributions .......................................................................... 4
1.3 Study Design Features 9
1.4 Descriptive Statistics .............................................................................. 13
1.5 Inferential Statistics ................................................................................ 16
1.6 Summary .................................................................................................. 21

Chapter 2 – Topics in Hypothesis Testing
2.1 Significance Levels 23
2.2 Power ....................................................................................................... 25
2.3 One-Tailed and Two-Tailed Tests ........................................................... 26
2.4 p-Values .................................................................................................... 27
2.5 Sample Size Determination ................................................................... 27
2.6 Multiple Testing....................................................................................... 30
2.7 Summary 40

Chapter 3 – The Data Set TRIAL
3.1 Introduction ............................................................................................. 41
3.2 Data Collection 41
3.3 Creating the Data Set TRIAL ................................................................ 44
3.4 Statistical Summarization ...................................................................... 47
3.5 Summary .................................................................................................. 54

Chapter 4 – The One-Sample t-Test
4.1 Introduction 55
4.2 Synopsis .................................................................................................... 55
4.3 Examples 56
4.4 Details & Notes ....................................................................................... 63

Chapter 5 – The Two-Sample t-Test
5.1 Introduction ............................................................................................. 67
5.2 Synopsis 67
5.3 Examples .................................................................................................. 68
5.4 Details & Notes 73



iv Contents



Chapter 6 – One-Way ANOVA
6.1 Introduction ............................................................................................. 79
6.2 Synopsis .................................................................................................... 79
6.3 Examples .................................................................................................. 82
6.4 Details & Notes ....................................................................................... 88

Chapter 7 – Two-Way ANOVA
7.1 Introduction 95
7.2 Synopsis 95
7.3 Examples 98
7.4 Details & Notes ..................................................................................... 119

Chapter 8 – Repeated Measures Analysis
8.1 Introduction ........................................................................................... 125
8.2 Synopsis .................................................................................................. 125
8.3 Examples ................................................................................................ 129
8.4 Details & Notes 160

Chapter 9 – The Crossover Design
9.1 Introduction 171
9.2 Synopsis 172
9.3 Examples 174
9.4 Details & Notes ..................................................................................... 185

Chapter 10 – Linear Regression
10.1 Introduction ........................................................................................... 191
10.2 Synopsis .................................................................................................. 191
10.3 Examples ................................................................................................ 194
10.4 Details & Notes 209

Chapter 11 – Analysis of Covariance
11.1 Introduction 221
11.2 Synopsis 222
11.3 Examples 225
11.4 Details & Notes ..................................................................................... 246

Chapter 12 – The Wilcoxon Signed-Rank Test
12.1 Introduction ........................................................................................... 253
12.2 Synopsis .................................................................................................. 253
12.3 Examples ................................................................................................ 254
12.4 Details & Notes 260

Chapter 13 – The Wilcoxon Rank-Sum Test
13.1 Introduction 263
13.2 Synopsis 263
13.3 Examples 265
13.4 Details & Notes ..................................................................................... 270



Contents v



Chapter 14 – The Kruskal-Wallis Test
14.1 Introduction ........................................................................................... 273
14.2 Synopsis .................................................................................................. 273
14.3 Examples ................................................................................................ 275
14.4 Details & Notes ..................................................................................... 279

Chapter 15 – The Binomial Test
15.1 Introduction 283
15.2 Synopsis 283
15.3 Examples 285
15.4 Details & Notes 289

Chapter 16 – The Chi-Square Test
16.1 Introduction ........................................................................................... 293
16.2 Synopsis .................................................................................................. 293
16.3 Examples ................................................................................................ 295
16.4 Details & Notes ..................................................................................... 308

Chapter 17 – Fisher’s Exact Test
17.1 Introduction 317
17.2 Synopsis 317
17.3 Examples 318
17.4 Details & Notes 321

Chapter 18 – McNemar’s Test
18.1 Introduction ........................................................................................... 325
18.2 Synopsis .................................................................................................. 325
18.3 Examples ................................................................................................ 326
18.4 Details & Notes .............