Human Developmental Biology

Danton Inc. O'Day

Description

In this book, early human development is covered from the formation of eggs and sperm through fertilization. It then progresses to the events that lead to the formation of tissues and organs in the embryo and fetus. The book is designed to give the reader an in-depth understanding of how development progresses by focusing on the central issues involved in the differentiation and morphogenesis of cells, tissues and organs. In addition to the fundamental topics of developmental biology, current issues such as artificial reproductive technologies are discussed. Developmental problems are also covered including Down syndrome, immotile cilia syndrome, spina bifida, fetal alcohol syndrome and the effects of thalidomide, to name a few.
This book is written in an easy to read style with lots of relevant examples and over 150 original full color figures. It is designed to meet the needs of students world-wide who want an accurate, informative and inexpensive book on human developmental biology. The book is suitable for use as a course textbook or as supplementary reading to help students understand how humans develop. Anyone who has taken a biology course will also find this book an enjoyable read, allowing them to update their understanding of current biomedical issues that make the news.

Sujets

• Life Sciences
• Sciences et techniques
• Developmental Biology
• Science

Informations

• Publié par: eBookIt.com
• Date de parution: 21 février 2013
• Nombre de lectures: 0
• EAN13: 9781456610081
• Langue: English
• Poids de l'ouvrage: 1 Mo

Extrait

Human
Developmental
Biology
 
 
Danton H. O’Day
 
 



Human Developmental Biology
Danton H. O’Day
 
 
Copyright 2012 Danton O'Day
 
All rights reserved.
 
No part of this book may be reproduced in any form or by any electronic or mechanical means including information
storage and retrieval systems, without permission in writing from the author. The only exception is by a reviewer, who may quote short excerpts in a review.


Preface
 
In this book, early human development is covered from the formation of eggs and sperm through fertilization. It then progresses to the events that lead to the formation of tissues and organs in the embryo and fetus. The book is designed to give the reader an in-depth understanding of how development progresses by focusing on the central issues involved in the differentiation and morphogenesis of cells, tissues and organs. In addition to the fundamental topics of developmental biology, current issues such as artificial reproductive technologies are discussed. Developmental problems are also covered including Down syndrome, immotile cilia syndrome, spina bifida, fetal alcohol syndrome and the effects of thalidomide, to name a few.
This book is written in an easy to read style with lots of relevant examples and over 150 original full color figures. It is designed to meet the needs of students world-wide who want an accurate, informative and inexpensive book on human developmental biology. The book is suitable for use as a course textbook or as supplementary reading to help students understand how humans develop. Anyone who has taken a biology course will also find this book an enjoyable read, allowing them to update their understanding of current biomedical issues that make the news.
 
About the Author
Danton H. O’Day, PhD, is Professor Emeritus in Biology on the University of Toronto Mississauga campus and in the Department of Cell and Systems Biology at the University of Toronto. He has lectured and done research on Cell Biology and Developmental Biology for over 40 years. To date he has over 120 referred publications in the field as well as several edited books and multiple book chapters. He has taught and lectured in Canada, the USA, UK, in many European countries and in Africa.
 
This book reflects his view of the cell and his desire to teach everyone about developmental biology and its significance in our lives. This is reflected not only in this volume but also in his recent eBooks:
The Human Cell—The Unit of Life and Disease (2012) ISBN-13: 978-1-4566-0941-2
How to Succeed at University, International Edition (2012) ISBN-13: 978-1-4566-0941-2
How to Succeed at University, Canadian Edition (2012) ISBN-13: 978-1-4566-0876-7 .
 
Chapter 1
An Introduction and Overview
Developmental biology is the field of biology that involves the study of how organisms grow and develop. The chapters in this book focus on human developmental biology by taking a linear approach. The book starts with the formation of sperm and eggs and finishes with the formation of specific tissues and organs. All of the major topics of developmental biology are addressed using well characterized and interesting examples.
The first part of the book begins with an overview of development and progresses to the origin and formation of the sex cells. Here we learn about factors ( determinants ) that determine the fate of the future gametes. After an overview of male and female anatomy, the processes of oogenesis (females) and spermatogenesis (males) are detailed to reveal how eggs and sperm form. The fundamental differences in structure and function of sperm and eggs will be discussed as well as the timing of the events. How each of these cells specialize ( cell differentiation ) at the cellular and molecular levels also will be detailed. The differentiation of eggs and sperm will provide the first examples of how cells specialize. There are an estimated 230 different types of cells in the body. Many examples of cell differentiation will be covered in subsequent chapters.
The gametes merge at fertilization to begin the processes of embryonic development. But fertilization isn't a random encounter between eggs and sperm with a chance result. Sperm are guided to the egg and, once there, a series of intercellular communications mediated by species-specific molecules guarantee that only the proper sperm will bind to and penetrate the egg. Fertilization is a highly controlled process. Often humans want to intervene in the process of fertilization to prevent it, so techniques of contraception have developed. Sometimes things go wrong and fertilization doesn't occur. In such cases, couples (and individuals) may opt for in vitro fertilization (IVF) which involves many of the new Assisted Reproductive Technologies (ART).
Successful fertilization, in vivo or in vitro, leads to the initiation of early embryonic development that begins with rapid divisions of the zygote called cleavage . Cleavage is a specialized type of mitosis that produces daughter cells called blastomeres . After a period of time the cleaving embryo becomes a multicellular blastocyst . The blastocyst can implant in the uterine wall to set up the placental relationship for further development. The human body is a complex of different organs, tissues and cell types that are arranged in a very precise spatial relationship. During embryonic development the body plan is established through the morphogenetic movements of gastrulation and neurulation . Gastrulation establishes the primary germ layers of the embryo: endoderm , mesoderm and ectoderm . While this is occurring, neurulation starts and ultimately results in the formation of the neural tube , the precursor of the brain and spinal cord . The forth germ layer, the neural crest , also forms during neurulation. The neural crest is involved in the formation of a diversity of cell types including pigment cells, various nerves and bone, among other cell types and tissues.
While the morphogenetic events of gastrulation and neurulation are occurring, the embryo is very susceptible to outside influences. During these critical periods agents called Teratogens, such as carcinogens, viruses and alcohol, can cause birth defects . Other abnormalities are caused by genetic defects .
 
Various developmental factors continue to come into play to regulate the differentiation of cells as exemplified by nerve cell differentiation. Cellular interactions also mediate the formation of tissues and organs. To understand how tissues and organs develop and the role of induction , we focus on two major examples. First limb development is detailed including the signaling events that occur. Then eye development becomes the organ of focus. The book finishes up by covering the topic of late inductions that occur not only during embryonic development but also throughout our lives. These include how hair, teeth and certain glands develop. The embryonic development of human mammary glands is also covered.
It will become clear that human developmental biology is a very dynamic and exciting topic. The central terms and concepts in this field have been introduced which will become clearer as each chapter in the book unfolds. So, before we continue, let’s take a quick summarized look at human development from birth to death.
Overview of Development
Gametogenesis : the formation of sperm and eggs.
Fertilization : fusion of a sperm and egg to form a zygote.
Cleavage : special, rapid mitotic cell divisions of the zygote to form a multicellular embryo.
Morphogenetic Movements : gastrulation and neurulation initially form primary germ lines establishing cell lineages in appropriate arrangements for further development.
Cell and Tissue Differentiation : cellular interactions regulate gene activity leading to specialization of cell types, tissues and organs.
Pattern and Polarity : humans have left-right, front-back (dorsal-ventral), top-bottom (anterior-posterior) symmetry that is reflected in the development of tissues and organs.
Growth and Maturation : the fetus grows as development continues while post-embryonic development is characterized by growth and sexual maturation (leading us back to gametogenesis and fertilization and the life cycle).
Senescence (aging) and Death : are the final developmental events of life leading to the end of the individual.
These key terms and concepts should be learned and understood before progressing in this book. Some of these topics are not covered (e.g., aspects of growth and maturation; senescence and death) in this volume because its primary focus is on embryonic development.
Chapter 2
Saga of the Sex Cells
Primordial germ cells (PGCs) are the source of sperm and eggs. They are specialized cells that are localized in our ovaries and testes. The primordial germ cells give rise to the male and female sex cells which in turn transmit the genome from generation to generation. The “Saga of the Sex Cells” is a true tale of cellular struggle, long journeys and tragic events. The future eggs and sperm are critical to the survival of each species. As a result, in some species, their fate is determined long before the egg begins to divide. Special factors (determinants) dictate that the cells that contain them will become sex cells. The cells that acquire these determinants then have a long haul ahead. First they must migrate through the embryonic tissues to the sites where the future gonads will form.
Along the way some will get lost and simply die. Other lost cells will not accept their inability to get to where they were supposed to and will begin to develop inappropriately forming dangerous malignant tumors called teratomas. Those that do arrive safely will have to wait many long years as the genital ridges first develop into gonads and then, at puberty, become functional producers of mature gametes. In the ovaries, a limited supply of