Cell Migration: Signalling and Mechanisms

Description

Cell migration is a highly complex process which involves several compartments of the cell, including surface receptors, signalling elements and the cytoskeleton. It plays an essential role in embryogenesis, wound healing and inflammatory responses, and a dysregulation of cell movement can cause pathological states such as developmental defects, chronic inflammation, cancer invasion and metastasis.

Informations

• Publié par: S. Karger AG
• Date de parution: 17 décembre 2009
• Nombre de lectures: 0
• EAN13: 9783805593229
• Langue: English
• Poids de l'ouvrage: 1 Mo

Extrait

Cell Migration: Signalling and Mechanisms
Translational Research in Biomedicine
Vol. 2
Series Editor
Samuel H.H. Chan    Kaohsiung
Associate Editor
Julie Y.H. Chan    Kaohsiung
 
Cell Migration: Signalling and Mechanisms
Volume Editors
Frank Entschladen    Witten
Kurt S. Zänker    Witten
20 figures and 2 tables, 2010
_________________________
_________________________
Prof. Dr. Frank Entschladen Institute of Immunology University of Witten/Herdecke DE-58448 Witten (Germany)
Prof. Dr. Kurt S. Zänker Institute of Immunology University of Witten/Herdecke DE-58448 Witten (Germany)
Library of Congress Cataloging-in-Publication Data
Cell migration: signalling and mechanisms/ volume editors, Frank Entschladen, Kurt 5. Zänker.
p. ; cm. –– (Translational research in biomedicine, ISSN 1662-405X; v. 2)
Includes bibliographical references and indexes. ISBN 978-3-8055-9321-2 (hard cover: alk. paper) 1. Cells migration. 2. Cellular signal transduction. I. Entschladen, Frank. II. Zänker, Kurt S. III. Series: Translational research in biomedicine, v. 2.1662-405X;
[DNLM: 1. Cell Movement. 2. Signal Transduction-physiology. QU 375 C3931 2010]
QH647.C439 2010 571.6’7––dc22
2009043614
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
© Copyright 2010 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Switzerland on acid-free and non-aging paper (ISO 9706) by Reinhardt Druck, Basel
ISSN 1662-405X
ISBN 978-3-8055-9321-2
e-ISBN 978-3-8055-9322-9
 
Contents
Foreword
Chan, S.H.H. (Kaohsiung)
Preface
Entschladen, F.; Zänker, K.S. (Witten)
The Migrating Cell
Entschladen, F.; Zänker, K.S. (Witten)
Stem Cell Migration in Health and Disease
Dittmar, T. (Witten); Kassmer, S.H. (New Haven, Conn.); Kasenda, B. (Freiburg); Seidel, J. (Berlin); Niggemann, B.; Zänker, K.S. (Witten)
Leukocyte Motility and Human Disease
Cooper, K.; Nuzzi, P.; Huttenlocher, A. (Madison, Wisc.)
Coordination of Leukocyte Polarity and Migration
Martín-Cófreces, N.B.; Serrador, J.M.; Sánchez-Madrid, F. (Madrid)
Positioning Phosphoinositide 3-Kinase in Chemokine and Antigen-Dependent T-Lymphocyte Navigation Mechanisms
Ward, S.G. (Bath)
Migration of Functionally Specialized T-Helper Cells: T FH Cells, Th17 Cells and FoxP3+ T Cells
Kim, C.H. (West Lafayette, Ind.)
ADAMs and Ectodomain Proteolytic Shedding in Leukocyte and Tumour Cell Migration
Ager, A.; Knäuper, V.; Poghosyan, Z. (Cardiff)
Guided Tour of Cell Migration: Signals and Pathways
Ratke, J.;Lang, K. (Witten)
Regulation of the E-Cadherin Adhesion Complex in Tumor Cell Migration and Invasion
Menke, A.; Giehl, K. (Ulm)
The Cytoskeletal Connection: Understanding Adaptor Proteins
Ziegler, W.H. (Leipzig)
Locomotor Force Generation by Myosins
Jbireal, J.M.A.; Entschladen, F.; Zänker, K.S. (Witten)
Author Index
Subject Index
 
Foreword
Welcome to volume two of Translational Research in Biomedicine , a monograph series dedicated to the dissemination of seminal information in contemporary biomedicine with a translational orientation.
As I pointed out in the inaugurating volume, translational research (TR) is now a household word in the arena of contemporary biomedical research, although a universal definition for this term is currently wanting. In a more restricted sense, TR is often associated with research and development based on the classical bench to bedside approach. Thus, it has been said that ‘the goal of TR is to implement in vivo measurements and leverage preclinical models that more accurately predict drug effects in humans’ [ 1 ]; or ‘TR describes a unidirectional effort to test in humans novel therapeutic strategies developed through experimentation’ [ 2 ]. The current enthusiasm over the application of genomic or stem cell research to therapeutic strategies is also grounded on a similar premise. In a broader sense, TR is taken as a bench to bedside and back approach to foster communication between the scientific community and clinical practitioners [ 1 ]. It is a concept that needs the attention from everyone and should be the foundation of a modern understanding of health provision [ 3 ].
If we subscribe to the philosophical connotation that medical research is for the betterment of humankind, then we should realize that there is no real demarcation between clinical (bedside) and preclinical (bench) research. This is because the only difference is that human subjects instead of animals, tissues or cells are employed in the studies. Nonetheless, governed by the same ethical principles and guidelines, all of them will reveal information in some aspects of biomedicine. Thus, this monograph series shall take a holistic view on TR that transcends the boundaries between bench and bedside research. Each volume shall be a synthesis of ideas, technologies and research outcomes that are associated with a particular theme in contemporary biomedicine, to be edited by experts in that field. The word ‘translation’ is most commonly defined as expression of words in another language. Its definitions can be extended to encompass expression in simpler language and uncomplicated interpretation. In this spirit, all chapters in this series will be presented in a fashion that is amenable to non-experts, be they scientists or clinical practitioners.
My sincere thanks go to Professors Frank Entschladen and Kurt S. Zänker, whose patience and expert efforts have made this timely volume on ‘Cell Migration: Signalling and Mechanisms’ a reality. I also wish to acknowledge the capable hands of Stefan Goldbach and Ruedi Jappert at S. Karger AG during the development and production of this series. Last but not least, the publication of Translational Research in Biomedicine would not have been possible without the foresight, enthusiasm and whole-hearted support of my dear friend, Dr. Thomas Karger.
Samuel H.H. Chan , Kaohsiung
Series Editor
References
1 Hörig H, Pullman W: From bench to clinic and back: perspective on the First IQPC Translational Research Conference. J Transl Med 2004;2:44-51.
2 Mankoff SP, Brander B, Ferrone S, Marincola FM: Lost in translation: obstacles to translational medicine. J Transl Med 2004;2:14-18.
3 Sonntag KC: Implementations of translational medicine. J Transl Med 2005;3:33-35.
 
Preface
Towards the Future of Cell Migration Research
As often stated, cellular migration is the crown achievement in biology. The chapters of this book highlight cell behavior with respect to inducing, controlling and terminating the mechanisms of cell migration. This book was only made possible because leading experts from different relevant disciplines contributed to the state of the art of this most fascinating field at the frontier of biological network research with special reference to the field of stem cells, tumor cells and immune competent cells.
Cellular migration research, which has in part been pioneered by the continuous contributions of the Institute of Immunology and Experimental Oncology, University Witten/Herdecke over the past 20 years, is now an area which is rapidly expanding and attracting an increased amount of interest among a broad audience of scientists and clinicians. Besides other cellular features such as proliferation, differentiation and apoptosis, the key elements of cellular migration are now focused on for their potentials in health and disease. Here, we provide a wide and updated view on the major mechanisms involved in cell migration.
We have been fortunate to recruit eminent scientists from around the world who give overviews in their fields of expertise. We would like to thank these distinguished authors for their contributions, which we hope will give the readers a sufficient and fascinating insight into this biological issue - cell migration.
We are grateful to Karger Publishers and to Samuel H.H. Chan, the Series Editor o