Nanomedicine - Basic and Clinical Applications in Diagnostics and Therapy

Description

Nanomedicine - the application of nanotechnology to human health - is a promising field of research at the interface of physical, chemical, biological, and medical science. Recent advances have made it possible to analyze biological systems at cellular and subcellular levels, offering numerous promising approaches to improve medical diagnosis and therapy. It is expected that nanomedicine will have a great impact especially on drug delivery and imaging. In this context, the development of targeted, highly specific nanoparticles is of pivotal importance. The results of these advances will offer personalized diagnostic tools and treatments in the future. Based on the 2nd Else Kröner-Fresenius-Symposium, this book presents a broad spectrum of topics ranging from nanoscale drug delivery/drug design to nanotoxicity and from diagnostics and imaging to therapeutic applications including antibody therapies. The contributions are authored by leading experts in the field and provide an excellent overview of the current knowledge in nanomedicine. Due to the interdisciplinary nature of the subject area this volume will be of special interest to physicians, biologists, chemists, engineers, and physicists as well as to students in the respective fields.

Informations

• Publié par: S. Karger AG
• Date de parution: 06 octobre 2011
• Nombre de lectures: 0
• EAN13: 9783805598194
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Nanomedicine – Basic and Clinical Applications in Diagnostics and Therapy
Else Kröner-Fresenius Symposia
Vol. 2
Series Editor
S. Pahernik    Heidelberg
 
Nanomedicine – Basic and Clinical Applications in Diagnostics and Therapy
Volume Editor
Christoph Alexiou    Erlangen
80 figures, 56 in color, and 11 tables, 2011
_________________________
Univ.-Prof. Dr. med. Christoph Alexiou Department of Otorhinolaryngology, Head and Neck Surgery Else Kröner-Fresenius-Stiftung Professorship for Nanomedicine Section for Experimental Oncology and Nanomedicine (SEON) University Hospital Erlangen Glückstrasse 10, DE-91054 Erlangen (Germany)
This book is sponsored by the Else Kröner-Fresenius-Stiftung.
Library of Congress Cataloging-in-Publication Data
Nanomedicine: basic and clinical applications in diagnostics and therapy / volume editor, Christoph Alexiou.
p. ; cm. –– (Else Kröner-Fresenius symposia, ISSN 1663-0114; v. 2)
Includes bibliographical references and indexes.
ISBN 978-3-8055-9818-7 (hard cover: alk. paper) –– ISBN 978-3-8055-9819-4 (e-ISBN)
I. Alexiou, Christoph. II. Series: Else Kröner-Fresenius symposia ; v. 2.1663-0114
[DNLM: 1. Nanomedicine––Congresses. 2. Nanostructures––diagnostic use––Congresses. 3. Nanostructures––therapeutic use––Congresses. QT36.5]
LC classification not assigned
616.07––dc23
2011029822
Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Cover art by C. Alexiou and the Else Kröner-Fresenius-Stiftung Professorship for Nanomedicine
© Copyright 2011 by S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland)
www.karger.com
Printed in Germany on acid-free and non-aging paper (ISO 9706) by Kraft Druck, Ettlingen
ISSN 1663-0114
ISBN 978-3-8055-9818-7
e-ISBN 978-3-8055-9819-4
 
Contents
Preface
Pahernik, S. (Heidelberg)
Introduction
Alexiou, C. (Erlangen)
Chapter 1: Speakers at the Symposium
_________________________
Speakers at the Symposium
Alexiou, C. (Erlangen)
Chapter 2: Nanoscale Drug Delivery/Drug Design
_________________________
Nanocarriers for the Delivery of Drugs, Genes, and Diagnostics
Torchilin, V.P. (Boston, Mass.)
Synthesis of Magnetic Nanoparticles and Magnetic Fluids for Biomedical Applications
Vékás, L. (Timisoara); Tombácz, E. (Szeged); Turcu, R. (Cluj-Napoca); Morjan, I. (Bucharest); Avdeev, M.V. (Dubna); Krasia-Christoforou, T. (Nicosia); Socoliuc, V. (Timisoara)
Nanotechnology-Based Spatiotemporal Controlled Drug Delivery Strategies
Biswas, S.; Kumar, C.S.S.R. (Baton Rouge, La.)
Chapter 3: Nanotoxicity
_________________________
Preclinical Efficacy and Toxicity Testing of Engineered Nanomaterials
Grossman, J.H.; McNeil, S.E. (Frederick, Md.)
Interactions of Carbon Nanotubes with the Immune System: Focus on Mechanisms of Internalization and Biodegradation
Fadeel, B. (Stockholm); Shvedova, A.A. (Morgantown, W. Va.); Kagan, V.E. (Pittsburgh, Pa.)
Chapter 4: Diagnostics and Imaging
_________________________
Magnetic Particle Imaging: Principles and Clinical Application
Buzug, T.M.; Sattel, T.F.; Erbe, M.; Biederer, S.; Finas, D.; Diedrich, K.; Vogt, F.; Barkhausen, J. (Lübeck); Borgert, J. (Hamburg); Lüdtke-Buzug, K.; Knopp, T. (Lübeck)
Nanoparticles in Clinical Trials
Hedgire, S.; McDermott, S.; Harisinghani, M. (Boston, Mass.)
Medical Applications of Plasmonic Nanoparticles
Alvarez-Puebla, R.A.; Liz-Marzán, L.M. (Vigo)
Pancreatic Cancer Stem Cells as New Targets for Diagnostics and Therapy
Clausell-Tormos, J.; Heeschen, C. (Madrid)
Chapter 5: Therapeutic Applications
_________________________
Nanomedicine Approaches for Cancer Stem Cell Targeting and Personalized Cancer Treatment
Block, I.; Schmidt, S.; Lund Hansen, P.; Riedel, A.; Christiansen, H.; Mollenhauer, J. (Odense)
Targeted Iron Oxide Nanocomplex as a Theranostic Agent for Cancer
Chang, E.H. (Washington, D.C.)
Local Cancer Therapy with Magnetic Nanoparticles
Tietze, R.; Lyer, S.; Schreiber, E.; Mann, J.; Dürr, S.; Alexiou, C. (Erlangen)
Parameters Influencing the Efficacy of Magnetic Heating of Small Breast Tumors
Hilger, I.; Kaiser, W. A. (Jena)
Chapter 6: Antibody Therapies
_________________________
Galectins, Glycans, and Mucins as Targets for Novel and Specific Antibody Therapies in Gynecologic Cancer Therapies
Jeschke, U.; Wiest, I.R.M.; Schindlbeck, C.; Dian, D.; Friese, K. (München)
The Commercial Development of Antibodies as Drugs
Eaton, M.A.W. (Berlin); Adair, J.R. (Sedgefield)
Author Index
Subject Index
 
Preface
This book series features the proceedings of the Else Kröner-Fresenius Symposia, which is intended to cover clinically relevant topics at the forefront of biomedical research. The meetings should give experts the opportunity to discuss the most recent findings of evolving fields of biomedicine and outline future research strategies.
Today's research is characterized by accelerated generation of biomedical data, an increasingly interdisciplinary and translational nature of biomedical science, as well as efforts to integrate the new results into health care.
In this context nanomedicine, i.e. applying nanotechnology to health, is one of the promising fields of biomedical research. The technology aims, at the level of molecules and atoms, to discover and develop new material for use in medicine. Nanotechnology is regarded as one of the key technologies of the future.
Nanomedicine has the potential to yield intelligent solutions to many of the current medical problems. Research in nanomedicine will provide a better insight into pathophysiology at the molecular and nanometric level. Novel promising solutions for intervention in chronic or acute pathologies are to be expected. Nanotechnology already impacts biomedical research. Thus, the first nanotechnology-based targeted drug delivery systems are already being used in clinical settings, and some are currently being investigated in clinical trials or are under development. Another highly important field of nanotechnology in medicine is diagnostics with the aim of yielding precise information at a nanoscale at a very early stage of the disease. Furthermore, new concepts using nanotechnology are being investigated to selectively target tumor diseases. Another promising related area of biomedical research is regenerative medicine leading to the development of artificial skin, bone, cartilage, and other tissue to restore organ function.
A wide variety of potential diagnostic and therapeutic applications of nanotechnology, as well as their basic effects on pathophysiology and toxicity, was discussed at the 2nd Else Kröner-Fresenius Symposia. The Else Kröner-Fresenius-Stiftung together with the Medical Faculty of Erlangen established a Professorship for Nanomedicine in 2009 headed by Dr. Christoph Alexiou. The foundation thanks him for organizing this excellent meeting.
The Else Kröner-Fresenius-Stiftung
In 1983, Else Kröner (1925-1988) founded the Else Kröner-Fresenius-Stiftung, a nonprofit foundation dedicated to promoting medical science, supporting medical education, and providing humanitarian aid.
Else Kröner, born Fernau, was born on May 15, 1925, in Frankfurt am Main, Germany. At the age of 3 years, her father died. After his death, she lived with her mother in the home of Dr. Eduard Fresenius, a pharmacist and owner of the Hirsch Pharmacy in Frankfurt, who founded the Fresenius pharmaceutical company in 1912. Dr. Eduard Fresenius, whose marriage was childless, took care of Else Fernau. In 1944, she started an internship at the Hirsch Pharmacy and decided to study pharmacy, which was supported by Dr. Eduard Fresenius. In 1946, Dr. Eduard Fresenius unexpectedly died. At this time, Else Fernau had not completed her pharmaceutical education. However, Dr. Eduard Fresenius bequeathed the Hirsch Ph