New findings of the correlation between acupoints and ...

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New findings of the correlation between acupoints and ...

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• Publié par: yxubemyd
• Nombre de lectures: 135
• Langue: English

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Pr. Ntl. d. Si. S Vl. 95, pp. 2670–2673, Mrh 1998 Physilgy

Nw findings f th rrltin btwn pints nd rrspnding brin rtis sing fntinl MRI (pntr y fMRI y rrltin btwn visl nd pntr stimltin) †‡ †§ §§ ¶\ Z. H.  H S. . * , HNG , J. P. J NS *, J. B. P RK , H. J. P RK , H. J. L  , . K. W NG , ND B. I. M IN ¶ † Dprtmnts f *Rdilgil Sins, Psyhitry, nd Hmn Bhvir, ndphthlmlgy, nivrsity f lifrni, Irvin,  92697;Dprtmnt f § ltril Sins, Kr dvnd Institt f Sin nd Thnlgy, Sl, Kr; ndDprtmnt f Mridinlgy, rintl Mdil llg, nd \ Dprtmnt f Physilgy, llg f Mdiin, Kyng H nivrsity, Sl, Kr mmnitd by Lwrn . Shpp, T&T Lbrtris, Pistwy, NJ, Nvmbr 13, 1997 (rivd fr rviw gst 25, 1997)

BSTRT prliminry stdy f th rrltin b-mdiin, sh s th strn Mdil Hndbk (1), whih is twn pntr pints (pints) fr th trtmnt f y drivd lrgly frm xprin witht sintifi rrltin. disrdrs sggstd by nint rintl litrtr nd th In rintl mdiin, pntr trtmnt ws blivd t rrspnding brin lliztin fr visin dsribd by Wst- trt dirtly th dissd rgns r rltd disrdrs witht rn mdiin ws prfrmd by sing fntinl MRI (fMRI). intrmdiry ntrl mhnisms. Fr xmpl, th visl- Th visin-rltd pint (V1) is ltd in th ltrl rltd pint (V1) (knwn s rinry blddr hnnl f spt f th ft, nd whn pntr stimltin is BL67) is blivd t b n fftiv pint tht dirtly trts prfrmd thr, tivtin f ipitl lbs is sn by fMRI. y-rltd disrdrs (2, 3); tht is, vris pints r Stimltin f th y by dirtly sing light rslts in similr rltd t rrspnding spifi rgns rthr thn vi th tivtin in th ipitl lbs by fMRI. Th xprimnt ws ntrl nrvs systm (NS). In Wstrn mdiin, hwvr, ndtd by sing nvntinl hkrbrd 8-Hz light- it is knwn tht mny disrdrs r ithr ntrlld r f lsh stimltin f th y nd bsrvtin f th tim-rs fftd by th brin, i.., spifi rrspnding brin fn- dt. This ws fllwd by stimltin f th V1 by sing th tinl rs. Sm bsi rltinships btwn th vris sm tim-rs prdigm s visl light stimltin. R- rgns nd rrspnding brin rtil rs hv bn slts btind with 12 vlntrs yildd vry ln dt nd dmnstrtd by th nwly dvlpd fMRI (6–13). Hmn vry ls rrltins btwn visl nd pntr stim- brin nd vris rgn fntins f th brin, sh s visl, ltin. W hv ls stimltd nnpints 2 t 5 m wy mtr, ditry, snsry, s wll s gnitiv, hv lrdy frm th visin-rltd pints n th ft s  ntrl, nd bn stdid by fMRI (12, 13). Ths rnt dvlpmnts tivtin in th ipitl lbs ws nt bsrvd. Th rslts (14 –17)in fMRI n b sd fr th qntittiv stdy f th btind dmnstrt th rrltin btwn tivtin f rrltin btwn vris pints nd spifi fntinl spifi rs f brin rtis nd rrspnding pint rs f th brin with th hp f stblishing  lr stimltin prditd by nint pntr litrtr. rrltin btwn pints nd rgn disrdrs r disss. If ths rrltins r fnd t xist, thn th trtmnt f rintl mdiin in gnrl nd pntr in prtilr sm disrdrs r disss by pntr my b d t th hv bn sd fr thsnds f yrs in hin, Kr, nd mditin f th NS, nt th dirt intrtin btwn Jpn. In th Wst, rintl mdiin, spilly tht f pints nd invlvd rgns. vntlly, fMRI my ls pntr, hs bn knwn nly rntly (1–3); hwvr, its filitt mr rt trtmnt f disrdrs nd disss ptn hs inrsd rpidly. Th dvlpmnt f rintl dvlpd frm mpiril dt nd xprins. Rntly, mdiin is rltivly slw nd still rlis n nint litrtr, sm pntr ffts hv bn rprtd whn sing whih is lrgly dsriptiv rthr thn qntittiv r vn fMRI (18, 19), bt n dirt brin–pint rrltin stdy ftl. In rintl mdiin thr hs bn littl ffrt t shw hs bn rprtd. th nntin btwn th brin nd vris disrdrs r Fig. 1 is  digrm shwing th nptl rltinship disss. n xmpl is th rltinship btwn visin nd th btwn th brin, rgns, nd pints. Bs  lrg visl rtx, whih is nknwn nd nt mntind in th mnt f xprimntl dt hs lrdy bn btind by litrtr f rintl mdiin. Th lk f sh infrmtin fMRI t dmnstrt th rltinship btwn th brin nd my b d t th mplxity f th brin, whih hs md this vris rgns, this digrm my prvid  rfrn pint fr infrmtin t mplx fr nint bsrvrs t mprhnd. th stblishmnt f nw rltinships t b btind btwn With th rnt dvlpmnt f psitrn missin tmgrphy pntr stimltin nd fntinl rs f brin rtx. (PT) (4, 5) nd MRI, mny srts f brin fntin r bing rvld bt still rmin qlittiv rthr thn qntittiv. MTHDS ND RSLTS Sin th dvlpmnt f fntinl MRI (fMRI) in 1992, srts f brin fntin hv bgn t b rvld nd xprimnts wr rrid t by sing th nvntinl gr- mystris sh s visl stimltin nd tivtin f rr- dint h (G) sqn with th 2.0 T whl-bdy MRI spnding brin rtis hv bgn t prvid ‘‘brin’’ nd systm. Hlthy hmn vlntrs (12 vlntrs, gs 21–30 ‘‘rgn’’ rltinships hithrt nknwn (6–13). Hw - yrs) wr stdid fr bth pntr nd visl light pntr rlly wrks is lrgly  mystry nd hs bn nithr stimltin. h vlntr ws psitind nd srd in th sintifilly prvn nr xprimntlly vrifid. pntr stndrd hd il t vid misrgistrtin rtifts. Initilly is lrgly dpndnt n th lssil litrtr f rintl fr h fMRI xprimnt, n invrsin-rvry T1-wightd img ws btind fr th rfrn ntmil img f th Th pblitin sts f this rtil wr dfryd in prt by pg hrg pymnt. This rtil mst thrfr b hrby mrkd ‘‘dvrtismnt’’ in bbrvitins: fMRI, fntinl MRI; V1, visin-rltd pint; rdn with 18 .S.. §1734 slly t indit this ft. NS, ntrl nrvs systm. ‡ © 1998 by Th Ntinl dmy f Sins 0027-8424y98y952670-4$2.00y0 T whm rprint rqsts shld b ddrssd. -mil: zh@ PNS is vilbl nlin t http:yywww.pns.rg. i.d. 2670