Time Is Ripe for Clinical Trials in Frontotemporal Degeneration 27 ...

Derek Tompkins & Lev Khazanovich

Description

• mémoire
• exposé - matière potentielle : by david knopman
• exposé
• exposé - matière potentielle : at ctad

Time Is Ripe for Clinical Trials in Frontotemporal Degeneration 27 December 2011. As trialists are retooling in the face of disappointing results in Alzheimer's disease (AD), researchers in frontotemporal degeneration (FTD) are learning from AD woes and gearing up to take a seat in the front row. This year's 4th International Conference on Clinical Trials in Alzheimer's Disease, (CTAD), held 3-5 November 2011 in San Diego, California, included a session on preparing for treatment trials in FTD.

• progranulin
• trials for orphan medications
• ftd
• ctad
• clinical trials
• drug
• trial
• disease
• patients

Sujets

• Mémoire
• Exposé
• Kramer
• Mackenzie
• Cummings

Informations

• Publié par: renef
• Nombre de lectures: 21
• Langue: English

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MnROAD Lessons Learned
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RTechnical Report Documentation Page
1. Report No. 2. 3. Recipients Accession No.
MN/RC-2007-06
4. Title and Subtitle 5. Report Date
MnROAD Lessons Learned January 2007
6.

7. Author(s) 8. Performing Organization Report No.
Derek Tompkins & Lev Khazanovich
9. Performing Organization Name and Address 10. Project/Task/Work Unit No.
Dept. of Civil Engineering
11. Contract (C) or Grant (G) No. University of Minnesota
500 Pillsbury Drive SE (c) 81655 (wo) 175
Minneapolis, MN 55455
12. Sponsoring Organization Name and Address 13. Type of Report and Period Covered
Minnesota Department of Transportation Final Report
14. Sponsoring Agency Code 395 John Ireland Boulevard Mail Stop 330
St. Paul, Minnesota 55155
15. Supplementary Notes
http://www.lrrb.org/PDF/200706.pdf
16. Abstract (Limit: 200 words)
The Minnesota Department of Transportation (MnDOT) began construction on the Minnesota Road Research
Project (MnROAD) in 1991 and opened the full-scale pavement research facility to live traffic in 1994. Since
the time of its construction, MnROAD, the first major test track since the AASHO Road Test of the 1950s and
1960s, has learned a number of lessons on behalf of the greater pavement community. As part of completing the
first phase of MnROAD (its first ten years of operation), researchers at the University of Minnesota reviewed the
many products of MnROAD’s first phase. The Lessons Learned project involved over fifty interviews, three
hundred published and unpublished reports, papers, and briefs, and an online survey of pavement professionals.
This report presents an overview of MnROAD products of interest at the local, state, and national levels.
Furthermore, the report provides extensive references for these products in hopes of increasing awareness of
MnROAD’s under-publicized contributions to pavement engineering.
17. Document Analysis/Descriptors 18. Availability Statement
pavement database, cold regions, accelerated pavement testing, No restrictions. Document available from:
full-scale experiments, test track expertise, pavement design, National Technical Information Services,
pavement modeling Springfield, Virginia 22161

19. Security Class (this report) 20. Security Class (this page) 21. No. of Pages 22. Price
Unclassified Unclassified 63



MnROAD Lessons Learned


Final Report




Prepared by:

Derek Tompkins
Pavement Research Institute
University of Minnesota

Lev Khazanovich
Department of Civil Engineering
University of Minnesota




January 2007




Published by:

Minnesota Department of Transportation
Research Services Section
395 John Ireland Boulevard, MS 330
St. Paul, Minnesota 55155-1899




This report represents the results of research conducted by the authors and does not necessarily represent
the views or policies of the Minnesota Department of Transportation and/or the Center for Transportation
Studies. This report does not contain a standard or specified technique.

The authors and the Minnesota Department of Transportation and/or Center for Transportation Studies do
not endorse products or manufacturers. Trade or manufacturers’ names appear herein solely because they
are considered essential to this report. Acknowledgements


The UM research team would like to thank all subjects for their candor and willingness to
participate in interviews and surveys. Furthermore, the work in the technical briefs and final
report is particularly indebted to Tom Burnham, Tim Clyne, Shongtao Dai, Bernard Izevbekhai,
Maureen Jensen, Dave Johnson, Marc Loken, John Pantelis, John Siekmeier, and Ben Worel of
the Mn/DOT Office of Materials for their reviews of early drafts and/or provision of materials
for research.
Table of Contents

Chapter 1. Introduction.......................................................................................................... 1
1.1. MnROAD Lessons Learned Project................................................................... 2
1.2. Additional MnROAD Objectives in Research.................................................... 3
1.2.1. Test Track Expertise…......................................................................... 3
1.2.2. Pavement Rehabilitation and Maintenance.......................................... 3
1.2.3. Non-pavement Topics.......................................................................... 4

Chapter 2. Overview of MnROAD Products......................................................................... 5
2.1. Database.............................................................................................................. 5
2.2. Test Track Expertise........................................................................................... 8
2.2.1. Instrumentation…................................................................................. 8
2.2.2. MnROAD Construction and Materials................................................ 8
2.2.3. Data Acquisition and Verification....................................................... 8
2.2.4. Forensic Trenching.............................................................................. 9
2.3. Research.............................................................................................................. 10

Chapter 3. Highlights of MnROAD Phase 1........................................................................... 11
3.1. Seasonal Variation in Pavements, Spring Load Limits, and Winter Overloads... 11
3.2. MnPAVE.............................................................................................................. 11
3.3. Verification of and Contribtions to Mechanistic-Empirical Design Methods
and Pavement Models.......................................................................................... 12
3.4. MnROAD and the Mechanistic-Empirical Pavement Design Guide................... 12
3.5. Thermal Cracking................................................................................................. 13
3.6. Whitetopping........................................................................................................ 13
3.7. SafeTruck............................................................................................................. 13
3.8. Adoption of New Products.................................................................................. . 14
3.9. Edge-joint Sealing................................................................................................ 15
3.10. Non-pavement Research.................................................................................... 15
3.11. Aggregate Road Research.................................................................................. 16
3.12. Oil Gravel Road Research.................................................................................. 17
3.13. Low-volume Road Design.................................................................................. 17

Chapter 4. Assessment of MnROAD Phase 1........................................................................ 18
4.1. Perspectives from Surveys and Interviews.......................................................... 18
4.2. Intangible Benefits............................................................................................... 18
4.2.1. Pioneer of Second-generation Test Tracks........................................... 18
4.2.2. Education in Pavement Engineer.......................................................... 19
4.3. MnROAD Partnerships........................................................................................ 20
4.3.1. Local Road Research Board.................................................................. 20
4.3.2. Out-of-state Agencies............................................................................ 20
4.3.3. Industry.................................................................................................. 21

Chapter 5. Conclusions about MnROAD Phase 1.................................................................... 22
5.1. Suggestions for Database........................................................................................ 22
5.2. Suggestions for Data Analysis............................................................................. 23
5.3. stions for Reporting and Research............................................................. 24
5.4. Other Recommendations..................................................................................... . 25

References............................................................................................................................... 26

Appendix A. Survey/Interview Subjects for the Lessons Learned Proje