Development and evaluation of a _1hn4_1hn4Ti-_1hn4_1hn4Sc radionuclide generator and labeling of biomolecules with _1hn4_1hn4Sc and _1hn6_1hn8Ga for PET imaging [Elektronische Ressource] / Loktionova, Natalia

Loktiono

Description

44 44Development and evaluation of a Ti/ Sc radionuclide generator 44 68and labeling of biomolecules with Sc and Ga for PET imaging. Dissertation zur Erlangung des Grades ”Doktor der Naturwissenschaften“ Im Promotionsfach Chemie am Fachbereich Chemie, Pharmazie und Geowissenschaften der Johannes Gutenberg-Universität in Mainz Loktionova Natalia geb. in Leningrad Mainz 2010 2 Abstract Non-invasive molecular-imaging technologies are playing a key role in drug discovery, development and delivery. Positron Emission Tomography (PET) is such a molecular imaging technology and a powerful tool for the observation of various deceases in vivo. However, it is limited by the availability of vectors with high selectivity to the target and radionuclides with a physical half-life which matches the biological half-life of the observed process. The 68 68Ge/ Ga radionuclide generator makes the PET-nuclide anywhere available without an on-68site cyclotron. Besides the perfect availability Ga shows well suited nuclide properties for PET, but it has to be co-ordinated by a chelator to introduce it in a radiopharmaceuticals. 68However, the physical half-life of Ga of (67.7 min) might limit the spectrum of clinical 68 68applications of Ga-labelled radiodiagnostics.

Informations

• Publié par: johannes_gutenberg-universitat_mainz
• Publié le: 01 janvier 2010
• Nombre de lectures: 51
• Langue: English
• Poids de l'ouvrage: 4 Mo

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