Fatty liver in men is associated with high serum levels of small, dense low-density lipoprotein cholesterol

Hosoyamada Kaori, Uto Hirofumi, Imamura Yasushi, Hiramine Yasunari, Toyokura Eriko, Hidaka Yoshihiro, Kuwahara Tomomi, Kusano Ken, Saito Kazuto, Oketani Makoto, Ido Akio, Tsubouchi Hirohito

Description

Aims Our study addressed potential associations between fatty liver and small, dense low-density lipoprotein cholesterol (sd-LDL-C) levels using a cross-sectional analysis. Methods We enrolled 476 male subjects. Serum sd-LDL-C concentrations were determined using precipitation assays. Results Subjects were divided into four groups based on triglyceride (TG) and LDL-C levels: A, TG < 150 mg/dl and LDL-C < 140 mg/dl; B, TG < 150 mg/dl and LDL-C ≥ 140 mg/dl; C, TG ≥ 150 mg/dl and LDL-C < 140 mg/dl; and D, TG ≥ 150 mg/dl and LDL-C ≥ 140 mg/dl. sd-LDL-C levels and the prevalence of fatty liver were significantly higher in groups B, C, and D than in group A. Subjects were also categorized into four groups based on serum sd-LDL-C levels; the prevalence of fatty liver significantly increased with increasing sd-LDL-C levels. Additionally, logistic regression analysis revealed an independent association between sd-LDL-C concentrations and fatty liver using such potential confounders as obesity and hyperglycemia as variables independent of elevated TG or LDL-C levels. Conclusions Fatty liver is a significant determinant of serum sd-LDL-C levels independent of the presence of obesity or hyperglycemia. Fatty liver may alter hepatic metabolism of TG and LDL-C, resulting in increased sd-LDL-C levels.

Sujets

• Fatty liver
• Metabolic syndrome

Informations

• Publié par: biomed
• Publié le: 01 janvier 2012
• Nombre de lectures: 8
• Langue: English

Extrait

Hosoyamadaet al. Diabetology & Metabolic Syndrome2012,4:34 http://www.dmsjournal.com/content/4/1/34

DIABETOLOGY& METABOLIC SYNDROME

R E S E A R C HOpen Access Fatty liver in men is associated with high serum levels of small, dense lowdensity lipoprotein cholesterol 1 21* 11,2 3 Kaori Hosoyamada , Hirofumi Uto , Yasushi Imamura, Yasunari Hiramine , Eriko Toyokura, Yoshihiro Hidaka , 4 45 22 2 Tomomi Kuwahara , Ken Kusano , Kazuto Saito , Makoto Oketani , Akio Idoand Hirohito Tsubouchi

Abstract Aims:Our study addressed potential associations between fatty liver and small, dense lowdensity lipoprotein cholesterol (sdLDLC) levels using a crosssectional analysis. Methods:We enrolled 476 male subjects. Serum sdLDLC concentrations were determined using precipitation assays. Results:Subjects were divided into four groups based on triglyceride (TG) and LDLC levels: A, TG<150 mg/dl and LDLC<140 mg/dl; B, TG<150 mg/dl and LDLC≥140 mg/dl; C, TG≥150 mg/dl and LDLC<140 mg/dl; and D, TG≥150 mg/dl and LDLC≥140 mg/dl. sdLDLC levels and the prevalence of fatty liver were significantly higher in groups B, C, and D than in group A. Subjects were also categorized into four groups based on serum sdLDLC levels; the prevalence of fatty liver significantly increased with increasing sdLDLC levels. Additionally, logistic regression analysis revealed an independent association between sdLDLC concentrations and fatty liver using such potential confounders as obesity and hyperglycemia as variables independent of elevated TG or LDLC levels. Conclusions:Fatty liver is a significant determinant of serum sdLDLC levels independent of the presence of obesity or hyperglycemia. Fatty liver may alter hepatic metabolism of TG and LDLC, resulting in increased sdLDLC levels. Keywords:Small dense lowdensity lipoprotein, Fatty liver, Type 2 diabetes mellitus, Metabolic syndrome

Introduction Atherogenic lipid profiles in patients with metabolic syn drome or glucose intolerance are characterized by hyper triglyceridemia, elevated apolipoprotein B levels, reduced highdensity lipoprotein cholesterol (HDLC) concentra tions, and an increased proportion of small, dense low density lipoprotein (sdLDL) particles [13]. Compared with large LDL, sdLDL particles show increased pene tration of the arterial wall, lower affinity for the LDL re ceptor, longer halflife in plasma, greater susceptibility to glycation, and lower resistance to oxidative stress, sug gesting that sdLDL is highly atherogenic [4,5]. Indeed,

* Correspondence: [e-mail] 1 Department of Internal Medicine, Kagoshima Kouseiren Hospital, 2225 Tenpozancho, Kagoshima 8900061, Japan Full list of author information is available at the end of the article

patients with high levels of sdLDL particles were shown to have an approximately 3fold increase in the risk of developing coronary heart disease compared with indivi duals with primarily large, buoyant LDL particles [6]. In addition, the sdLDLC concentration has been suggested to be a better surrogate marker than the LDLC con centration for the severity of coronary heart disease [7]. The presence of fatty liver is an independent predictor of coronary heart disease [810]. In addition, fatty liver is a manifestation of metabolic syndrome, and is associated with obesity, type 2 diabetes mellitus (T2DM), and hypertriglyceridemia [11]. In patients with T2DM or metabolic syndrome, fatty liver may enhance atherogen esis by increasing levels of sdLDL particles [12,13]. The precise role of fatty liver in the pathogenesis of sdLDL, however, is still unclear. In the present study, we

© 2012 Hosoyamada et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.