MR-compatible blood sampler for PET [Elektronische Ressource] / vorgelegt von Johannes Breuer

Description

MR-Compatible Blood Samplerfor PETI n a u g u r a l - D i s s e r t a t i o nzurErlangung des Doktorgradesder Mathematisch-Naturwissenschaftlichen Fakult atder Universit at zu K olnvorgelegt vonJohannes Breueraus DortmundK oln2009Berichterstatter: Prof. Dr. JolieProf. Dr. ZilgesProf. Dr. WienhardTag der letzten mundlic hen Prufung: 23. April 2009AbstractOver the last few years, the idea of simultaneous MR-PET imaging has attractedmore and more research interest. This new bimodal technique promises accuratestructural and functional information of the investigated object at the same time.While PET-CT has already established as a powerful bimodal imaging technique,MR o ers better distinction of soft matter, which can be advantageous especiallyfor brain research. Future studies in this eld could also include simultaneous scanswith fMRI and PET.For certain measurements (e.g. cerebral blood ow, metabolic rates), the quantita-tive analysis of PET data requires knowledge of the arterial input function (time-activity-curve of patient blood). In other words, the amount of radioactivity in thearterial blood has to be monitored constantly. Ordinary, commercially availableblood sampling systems are based on Photo Multiplier Tubes (PMTs) that cannotbe operated in an MR environment. An MR-compatible blood sampler was thereforedesigned and built to be able to exploit the full potential of hybrid MR-PET.Basically, the new device works as follows.

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• Publié par: universitat_zu_koln
• Publié le: 01 janvier 2009
• Nombre de lectures: 17
• Langue: English
• Poids de l'ouvrage: 4 Mo

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