New approaches in tumour immunology [Elektronische Ressource] : implications from mass spectrometric analyses of HLA-ligands / vorgelegt von Andreas Oliver Weinzierl

Description

New approaches in tumour immunology:Implications from mass spectrometric analyses ofHLA-ligandsNeue Ansätze in der Tumorimmunologie:Implikationen aus der massenspektrometrischenAnalyse von HLA-LigandenDISSERTATIONder Fakultät für Chemie und Pharmazieder Eberhard Karls-Universität Tübingenzur Erlangung des Grades eines Doktorsder Naturwissenschaften2008vorgelegt vonAndreas Oliver WeinzierlTag der mündlichen Prüfung 31.01.2008Dekan: Prof. Dr. L. Wesemann1. Berichterstatter Prof. Dr. S. Stevanović2. Berich Prof. Dr. H.-G. RammenseePrefaceSome chapters of this thesis have been published before. At the beginning ofsuch chapters, it is indicated which experiments were done by the author of thisthesis, which persons contributed to the publication, and in which journal thework has been published.Contents1. Introduction I: Tumour vs. normal tissue – Differences at variouslevels 11.1. Differences from a physiological point of view . . . . . . . . . . . 11.1.1. Hypoxia and angiogenesis . . . . . . . . . . . . . . . . . . 11.1.2. Tumour microenvironment and inflammation . . . . . . . . 21.2. Differences by losing key gene transcripts and proteins . . . . . . 31.2.1. Inactivation of tumour suppressor genes . . . . . . . . . . 31.2.2. TAP deletion . . . . . . . . . . . . . . . . . . . . . . . . . 31.3. Differences as observable by the adaptive immune system . . . . . 41.3.1. Antigen recognition by T lymphocytes . . . . . . . . . . . 41.3.2.

Sujets

• Gesundheit

Informations

• Publié par: eberhard_karls_universitat_tubingen
• Publié le: 01 janvier 2008
• Nombre de lectures: 10
• Langue: English
• Poids de l'ouvrage: 19 Mo

Extrait