Notch1 and Lymphotoxin {β [beta] receptor in thymopoiesis [Elektronische Ressource] / vorgelegt von Vera Sofia Correia Martins

Sujets

• Biologie

Informations

• Publié par: albert-ludwigs-universitat_freiburg
• Publié le: 01 janvier 2008
• Nombre de lectures: 23
• Langue: English
• Poids de l'ouvrage: 18 Mo

Extrait

Cover image – murine thymus section immunostained with MHCII

Notch1 and Lymphotoxin β receptor
in thymopoiesis





Inaugural-Dissertation
zur
Erlangung der Doctorwürde
der Fakultät für Biologie
der Albert-Ludwigs-Universität
Freiburg im Breisgau




vorgelegt von
Vera Sofia Correia Martins

aus
Lissabon, Portugal





Freiburg im Breisgau, Oktober 2007



Dekan der Fakultät: Prof. Dr. Ralf Reski
Promotionsvorsitzender: Prof. Dr. Samuel Rossel



Betreuer der Arbeit: Prof. Dr. Thomas Boehm
Referent: Prof. Dr. Thomas Boehm
Koreferent: Prof. Dr. Hanspeter Pircher
3. Prüfer: Dr. Hassan Jumaa



Tag der Verkündigung des Prüfungsergebnisses: 12.12.2007





Max-Planck-Institute of Immunobiology
Department of Developmental Immunology

Albert-Ludwigs-Universität Freiburg
Faculty of Biology





Notch1 and Lymphotoxin β receptor
in thymopoiesis


Vera Sofia Correia Martins









Dissertation submitted to obtain a
degree of Doctor rerum naturalium by the
Albert-Ludwigs-Universität
Faculty of Biology
Freiburg, Germany



Supervisor
Prof. Dr. Conrad C. Bleul
Max-Planck-Institute of Immunobiology

Co-Supervisor
Prof. Dr. Thomas Boehm
Max-Planck-Institute of Immunobiology








“It is not the strongest of the species that survives,
nor the most intelligent, but
the most responsive to change.”

Charles Darwin





To Ricardo and Diogo
Preface

This thesis assembles data obtained during my Ph.D. research project carried
out at the Max-Planck-Institute of Immunobiology, from January 2004 to
October 2007. The work was supervised by Prof. Dr. Conrad Bleul and Prof.
Dr. Thomas Boehm.

Fundação para a Ciência e Tecnologia, Portugal, supported me with the
Ph.D. fellowship SFRH/BD/12502/2003.

This thesis is structured in 4 chapters, which are preceded by an Abstract.
Chapter 1 consists of a general introduction to the immune system, the
importance of the thymus and thymopoiesis. The objectives of this thesis are
outlined at the end of this chapter.
The results are detailed in chapters 2 and 3. Chapter 2 includes a specific
introduction to lymphopoiesis and the role of Notch1 in early T cell
development, followed by the Materials and Methods and the data obtained.
The Materials and Methods section includes the protocols used for this
chapter and only in two sub-sections, which are indicated, overlap with the
manuscripts. Because this data stems from a collaborative project in the lab,
the two manuscripts that resulted from this work are also presented, with my
contribution stated before each manuscript. Chapter 3 concerns the role of
the lymphotoxin receptor in thymic epithelial differentiation and function; it
begins with an introductory overview and a brief presentation of the results.
A manuscript that arose from this work is included in this chapter. Since this represents only my results on this topic, no other sections are
added in this chapter.
Chapter 4 encompasses the final, general discussion of this work.
The references section lists all citations included in this thesis except the
ones that are part of the manuscripts.
The Appendix gives my Curriculum Vitae and the list of the publications to
which I have contributed.
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