'THE P21 PROTEIN AND DNA DAMAGE' PROTEIN P21 UND DNA-SCHÄDEN Von dem Fachbereich Biologie der Technischen Universität Darmstadt (D17) zur Erlangung des akademischen Grades eines Doctor rerum naturalium genehmigte Dissertation von Dipl. Biol. Jeanette Heede Rudolph aus Darmstadt. 1. Referent: Prof. Dr. G. Kraft 2. Referent: Prof. Dr. T. W. Holstein 3. Referent: Prof. Dr. P. G. Layer Tag der Einreichung 30. August 2007 Tag der mündlichen Prüfung 01. February 2008 Darmstadt 2007 D17 THE P21 PROTEIN AND DNA DAMAGE by Dipl. Biol. Jeanette Heede Rudolph from Darmstadt A thesis submitted in partial fulfilment of the requirements for the degree of Doctor rerum naturalium Technische Universität Darmstadt Darmstadt 2007 Approved by Prof. Dr. G. Kraft Prof. Dr. T. W. Holstein Prof. Dr. P. G. Layer Date of submission 30. August 2007 Date of oral examination 01. February 2008 D17 TECHNISCHE UNIVERSITÄT DARMSTADT THE P21 PROTEIN AND DNA DAMAGE by Dipl. Biol. Jeanette Heede Rudolph ABSTRACT Radiation-induced DNA lesions lead to the activation of complex damage response pathways in mammalian cells.