Fetal and Neonatal Physiology

Richard Polin

Description

Offering the comprehensive, authoritative information needed for effective diagnosis, treatment, and management of sick and premature infants, Fetal and Neonatal Physiology, 6th Edition, is an invaluable resource for board review, clinical rounds, scientific research, and day-to-day practice. This trusted two-volume text synthesizes recent advances in the field into definitive guidance for today’s busy practitioner, focusing on the basic science needed for exam preparation and key information required for full-time practice. It stands alone as the most complete text available in this complex and fast-changing field, yet is easy to use for everyday application.

• Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants.

• Contains new chapters on Pathophysiology of Genetic Neonatal Disease, Genetic Variants and Neonatal Disease, and Developmental Biology of Lung Stem Cells, as well as significantly revised chapters on Cellular Mechanisms of Neonatal Brain Injury, Neuroprotective Therapeutic Hypothermia, Enteric Nervous System Development and Gastrointestinal Motility, and Physiology of Twin-Twin Transfusion.

• Features 1,000 full-color diagrams, graphs and anatomic illustrations, 170+ chapters, and more than 350 global contributors.

• Includes chapters devoted to clinical correlation that help explain the implications of fetal and neonatal physiology, as well as clinical applications boxes throughout.

• Provides summary boxes at the end of each chapter and extensive cross-referencing between chapters for quick reference and review.

• Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.

Sujets

• Médecine
• Gynécologie et Obstétrique
• Pediatrics
• Medical

Informations

• Publié par: Elsevier
• Date de parution: 29 juillet 2021
• Nombre de lectures: 0
• EAN13: 9780323712859
• Langue: English
• Poids de l'ouvrage: 176 Mo

Extrait

Fetal and Neonatal Physiology
Sixth Edition

Richard A. Polin, MD
William T. Speck Professor of Pediatrics, College of Physicians and Surgeons, Columbia University, Executive Vice-Chair, Department of Pediatrics, Morgan Stanley Children’s Hospital of New York–Presbyterian, Columbia University Irving Medical Center, New York, New York
Steven H. Abman, MD
Professor, Department of Pediatrics, Director, Pediatric Heart Lung Center, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora, Colorado
David H. Rowitch, MD ScD FMedSci FRS
Professor and Head Department of Paediatrics, Wellcome Trust—Medical Research, Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
Adjunct Professor, Department of Pediatrics, University of California, San Francisco, San Francisco, California
William E. Benitz, MD
Philip Sunshine Professor in Neonatology Emeritus, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, California
William W. Fox, MD
Editor Emeritus, Perelman School of Medicine, The University of Pennsylvania
Disclaimer
This title includes additional digital media when purchased in print format. For this digital book edition, media content may not be included.
Table of Contents
Cover image
Title page
Copyright
Dedicated To
Contributors
Preface
VOLUME 1
Section I. Genetics and Embryology
1. Basic Genetic Principles
2. Epigenetics
3. Basic Embryology
4. Regulation of Embryogenesis
5. The Extracellular Matrix in Development
6. Angiogenesis
7. Prenatal Diagnosis
Section II. Placenta and Intrauterine Environment
8. Placental Development
9. Regulation of the Placental Circulation
10. Mechanisms of Transfer Across the Human Placenta
11. Endocrine and Paracrine Function of the Human Placenta
12. Intra-Amniotic Infection/Inflammation and the Fetal Inflammatory Response Syndrome
13. Fetal Origins of Adult Disease: A Classic Hypothesis With New Relevance
14. Placental Function in Intrauterine Growth Restriction
Section III. Developmental Pharmacology
15. Basic Pharmacologic Principles
16. Principles of Pharmacokinetics
17. The Physiology of Placental Drug Disposition
18. Pharmacogenomics
19. Drug Distribution in Fetal Life
20. Drug Transfer During Breastfeeding
Section IV. Intrauterine and Postnatal Growth
21. Placental and Fetal Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction
22. Endocrine Factors Affecting Neonatal Growth
23. Human Milk Composition and Function in the Infant
24. Physiology of Lactation
Section V. Perinatal Iron, Mineral, and Vitamin Metabolism
25. Fetal and Neonatal Iron Metabolism
26. Fetal and Neonatal Calcium, Phosphorus, and Magnesium Homeostasis
27. Zinc in the Fetus and Neonate
28. Vitamin A Metabolism in the Fetus and Neonate
29. Vitamin E Nutrition in Pregnancy and the Newborn Infant
30. Vitamin K Metabolism in the Fetus and Neonate
Section VI. Lipid Metabolism
31. Maternal-Fetal Transfer of Lipid Metabolites
32. Brown Adipose Tissue: Development and Function
33. Lipids as an Energy Source for the Premature and Term Neonate
34. Ketone Body Metabolism in the Neonate
35. Long-Chain Polyunsaturated Fatty Acids in Neurodevelopment
Section VII. Carbohydrate Metabolism
36. Glucose Metabolism in the Fetus and Newborn, and Methods for Its Investigation
37. Oxygen Consumption and General Carbohydrate Metabolism of the Fetus
38. Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period
39. Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development
Section VIII. Protein Metabolism
40. General Concepts of Protein Metabolism
41. Placental Transfer and Fetal Requirements of Amino Acids
Section IX. Thermoregulation
42. Temperature Control in Newborn Infants
Section X. Skin
43. Structure and Development of the Skin and Cutaneous Appendages
44. Physiologic Development of the Skin
Section XI. Fetal and Neonatal Cardiovascular Physiology
45. Cardiovascular Development
46. Developmental Electrophysiology in the Fetus and Neonate
47. Developmental Biology of the Pulmonary Vasculature
48. Development of the Gastrointestinal Circulation in the Fetus and Newborn
49. Physiology of Congenital Heart Disease in the Neonate
50. Regulation of Cardiovascular Function During Fetal and Newborn Life
51. Nutritional and Environmental Effects on the Fetal Circulation
52. Mechanisms Regulating Closure of the Ductus Arteriosus
53. Umbilical Circulation
54. Fetal and Placental Circulation During Labor
Section XII. The Lung
55. Normal and Abnormal Structural Development of the Lung
56. Regulation of Alveolarization
57. Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth
58. Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis
59. Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung
60. Upper Airway Structure: Function, Regulation, and Development
61. Regulation of Lower Airway Function
62. Functional Development of Respiratory Muscles
63. Mechanics of Breathing
64. Pulmonary Gas Exchange in the Developing Lung
65. Oxygen Transport and Delivery
66. Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate
67. Basic Mechanisms of Oxygen Sensing and Adaptation to Hypoxia
68. Evaluation of Pulmonary Function in the Neonate
69. Mechanisms of Neonatal Lung Injury
70. Impaired Lung Growth After Injury in Preterm Lung
71. Antenatal Factors That Influence Postnatal Lung Development and Injury
72. Regulation of Pulmonary Circulation
Section XIII. Surfactant
73. Historical Perspective
74. Developmental Biology of Lung Stem Cells
75. Surfactant Homeostasis: Composition and Function of Pulmonary Surfactant Lipids and Proteins
76. Structure and Development of Alveolar Epithelial Cells
77. Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion
78. Antenatal Hormonal Therapy for Prevention of Respiratory Distress Syndrome
79. Surfactant Treatment
80. Genetics and Physiology of Surfactant Protein Deficiencies
Section XVI. Physiology of Gastrointestinal Tract in the Fetus and Neonate
81. Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development
82. Organogenesis of the Gastrointestinal Tract
83. Development of Gastric Secretory Function
84. Development of the Enteric Nervous System and Gastrointestinal Motility
85. Development of the Endocrine and Exocrine Pancreas
86. Digestive-Absorptive Functions in Fetuses, Infants, and Children
87. The Developing Microbiome of the Fetus and Neonate: A Multiomic Approach
Section XV. Liver and Bilirubin Metabolism
88. Organogenesis and Histologic Development of the Liver
89. Bile Acid Metabolism During Development
90. Fetal and Neonatal Bilirubin Metabolism
91. Hereditary Contributions to Neonatal Hyperbilirubinemia
92. Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia
VOLUME 2
Section XVI. The Kidney
93. Development of the Kidney: Morphology and Mechanisms
94. Functional Development of the Kidney in Utero
95. Development and Regulation of Renal Blood Flow in the Neonate
96. Postnatal Development of Glomerular Filtration Rate in Neonates
97. Renal Transport of Sodium During Development
98. Potassium Homeostasis in the Fetus and Neonate
99. Role of the Kidney in Calcium and Phosphorus Homeostasis
100. Transport of Amino Acids in the Fetus and Neonate
101. Organic Anion Transport in the Developing Kidney
102. Concentration and Dilution of Urine
103. Urinary Acidification
104. Response to Nephron Loss in Early Development
Section XVII. Fluid and Electrolyte Metabolism
105. Fluid Distribution in the Fetusand Neonate
106. Regulation of Acid-Base Balance in the Fetus and Neonate
Section XVIII. Developmental Hematopoiesis
107. Developmental Biology of Hematopoietic Stem Cells
108. Neutrophil Granulopoiesis and Homeostasis
109. Developmental Erythropoiesis
110. Developmental Megakaryopoiesis
Section XIX. Hemostasis
111. Developmental Hemostasis
112. Platelet–Vessel Wall Interactions
Section XX. Developmental Immunobiology
113. Host Defense Mechanisms Against Bacteria
114. Host Defense Mechanisms Against Fungi
115. Host Defense Mechanisms Against Viruses
116. T-Cell Development
117. B-Cell Development
118. Mononuclear Phagocyte System
119. Normal and Abnormal Neutrophil Physiology in the Newborn
120. The Complement System of the Fetus and Newborn
121. Cytokines and Inflammatory Response in the Fetus and Neonate
122. Immunology of Human Milk
123. Neonatal Pulmonary Host Defense
Section XXI. Neurology
124. Development of the Nervous System
125. Mechanisms of Cell Death in the Developing Brain
126. Development of the Blood-Brain Barrier
127. Trophic Factor, Nutritional, and Hormonal Regulation of Brain Development
128. Developmental Aspects of Pain
129. Cerebellar Development—The Impact of Preterm Birth and Comorbidities
130. Electroencephalography in the Preterm and Term Infant
131. Intraventricular Hemorrhage in the Neonate
132. Pathophysiology of Neonatal White Matter Injury
133. Cellular and Molecular Mechanisms of Neonatal Brain Injury and Neuroprotection
134. Neuroprotective Therapeutic Hypothermia
Section XXII. Special Sensory Systems in the Fetus and Neonate
135. Early Development of the Human Auditory System
136. Development of Olfaction and Taste in the Human Fetus and Neonate
Section XXIII. Musculoskeletal
137. The Growth Plate: Embryologic Origin, Structure, and Function
138. Ontogenesis of Striated Muscle
Section XXIV. Endocrine Function
139. Hypothalamus: Neuroendometabolic Center
140. Growth Factor Regulation of Fetal Growth
141. Growth Horm