Head and Neck Cancer, An Issue of Hematology/Oncology Clinics of North America

Alexander Colevas

Description

This issue of Hematology/Oncology Clinics of North America is devoted to Head and Neck Cancer. Guest Editor Alexander Colevas, MD has assembled a group of expert authors to review the following topics: Epidemiology of SCCHN; Genetics of Head and Neck Cancers; Molecular Biology of Head and Neck Cancers; Quality of Life in Head and Neck Cancer Treatment; Nasopharyngeal Carcinoma; Evolving Surgical Techniques in SCCHN; Radiation Oncology New Approaches in SCCHN; Thyroid Gland Malignancies; Sequential and Concurrent Chemoradiation; Systemic Chemotherapy for SCCHN Focus on New targets and Agents; EGFR Inhibition in SCCHN; Diagnostic and Therapeutic Assessment Imaging in Head and Neck Cancer; Salivary Gland Cancers; Immunotherapy in SCCHN; Human Papillomavirus in SCCHN; and Supportive Care Issues in SCCHN Treatment and Survivorship: Dental, Nutrition, Speech and Swallowing, Depression.

Sujets

• Médecine
• Médecine Générale
• Hermatology
• Medical

Informations

• Publié par: Elsevier
• Date de parution: 07 janvier 2016
• Nombre de lectures: 0
• EAN13: 9780323402514
• Langue: English
• Poids de l'ouvrage: 3 Mo

Extrait

Head and Neck Cancer
Hematology/Oncology Clinics Of North America
Editor
A. Dimitrios Colevas, MD
Division of Medical Oncology, Stanford University, Stanford Cancer Institute, Stanford, CA, USA
Consulting Editors
George P. Canellos
H. Franklin Bunn

Clinics Review Articles

www.hemonc.theclinics.com

December 2015 Volume 29 Number 6
Table of Contents
Cover image
Title page
Copyright
Contributors
Consulting Editors
Editor
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Preface. New Diseases and New Treatments-Head and Neck Cancer Updates
Molecular Aspects of Head and Neck Cancer Therapy
Key points
Introduction
Tumor suppressors frequently drive head and neck squamous cell carcinoma but are difficult to target
Oncogene mutations are uncommon in head and neck squamous cell carcinoma with limited potential for targeted therapy in specific contexts
Human papilloma virus infection and integration alters tumor biology and triggers carcinogenesis by divergent biologic mechanisms than smoking and alcohol-related head and neck squamous cell carcinoma
Intratumor heterogeneity poses unique therapeutic challenges and opportunities in head and neck squamous cell carcinoma
Additional frontiers in head and neck squamous cell carcinoma diagnostics and therapeutics
Summary
References
Novel Targeted Agents in Head and Neck Squamous Cell Carcinoma
Key points
Introduction
DNA damage response and cell cycle regulation targeted agents
PI3K-mTOR targeted agents
Notch pathway targeted agents
Transmembrane growth factor receptor targeted agents
Angiogenesis targeted agents
Summary
References
Epidermal Growth Factor Receptor Inhibition in Squamous Cell Carcinoma of the Head and Neck
Key points
The epidermal growth factor receptor
Inhibition of epidermal growth factor receptor
Strategies to overcome resistance to anti-epidermal growth factor receptor therapy
Summary
References
Immunotherapy for Head and Neck Squamous Cell Carcinoma
Key points
Introduction
Immune checkpoint blockade
Augmenting cetuximab-based immunotherapy
Vaccines
Engineered T cells
Summary
References
Anticipation of the Impact of Human Papillomavirus on Clinical Decision Making for the Head and Neck Cancer Patient
Key points
Introduction
Human papillomavirus biology
Epidemiology of human papillomavirus-positive oropharyngeal cancer
Human papillomavirus tumor status, race, and survival
Human papillomavirus status, tumor staging, and prognosis
Human papillomavirus status, surgical resection, extracapsular extension, and risk of cancer progression
Tumor human papillomavirus status and overall survival postprogression
Human papillomavirus status and clinical trial design
References
Sequential and Concurrent Chemoradiation: State of the Art
Key points
Introduction
Summary of recent randomized clinical trials comparing sequential chemoradiotherapy versus concurrent chemoradiotherapy
Larynx preservation randomized trials: sequential chemoradiotherapy versus concurrent chemoradiotherapy
Closing the controversy: ongoing randomized phase III trials of sequential chemoradiotherapy versus concurrent chemoradiotherapy
Patient selection and risk stratification in locally advanced head and neck cancer: one size does not fit all
State of the art: future directions
Summary
References
Transoral Endoscopic Head and Neck Surgery: The Contemporary Treatment of Head and Neck Cancer
Key points
Background and introduction
Transoral endoscopic head and neck surgery
Oncologic outcomes of endoscopic head and neck surgery
Functional outcomes of endoscopic head and neck surgery
Role of endoscopic head and neck surgery in recurrent oropharyngeal cancer
Future perspective and summary
References
Radiation Oncology-New Approaches in Squamous Cell Cancer of the Head and Neck
Key points
Introduction
Imaging advances
Advances in radiation delivery
Clinically based advances
Summary
References
Chemotherapy for Nasopharyngeal Carcinoma - Current Recommendation and Controversies
Key points
Introduction
Background for the current guidelines
Current international guidelines
Unanswered questions and recent studies
Summary
References
Thyroid Gland Malignancies
Key points
Introduction
Genetics of thyroid cancer
Nonpharmacologic therapy
Pharmacologic therapies
Summary
References
Salivary Gland Malignancies
Key points
Introduction
Initial evaluation
Surgical management
Radiation therapy
Systemic therapy
Ongoing research and future directions
References
Supportive Care and Survivorship Strategies in Management of Squamous Cell Carcinoma of the Head and Neck
Key points
Introduction
Survivorship care plans
Cancer treatment-related physical effects
Cancer-related psychological distress
Substance abuse and survivorship
Oncologic surveillance and detection of second primary malignancies
Summary
References
Index
Copyright
ELSEVIER
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HEMATOLOGY/ONCOLOGY CLINICS OF NORTH AMERICA Volume 29, Number 6
December 2015 ISSN 0889-8588, ISBN 13: 978-0-323-40250-7
Editor: Jennifer Flynn-Briggs
Developmental Editor: Kristen Helm
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Contributors
Consulting Editors
GEORGE P. CANELLOS, MD , William Rosenberg Professor of Medicine, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts