PET Imaging of Infection and Inflammation, An Issue of PET Clinics

Hongming Zhuang, Alavi Abass

Description

PET/CT holds great promise for the management of many types of infection and inflammation. This issue discusses many of these uses, starting with arthroplasty-associated infection. FDG PET/CT also has utility in inflammatory bowel disease. This issue also discusses the utilization of FDG PET and PET/CT in the evaluation of diabetic foot, and in monitoring therapeutic effect in patients without malignancy. PET/CT is reviewed regarding its use in patients with sarcoidosis or IgG4 disease. Also covered is the application of FDG PET/CT in detecting the source of fever of unknown origin. Artherosclerosis and vasculitis can be assessed by PET/CT and FDG PET/CT can also be used in the management of severe infection in patients with malignancies. Finally, the issue discusses the use of PET and PET/CT in the evaluation of osteomyelitis.

Sujets

• Nuclear Medicine
• Radiotherapy
• Medical
• Médecine
• Radiology

Informations

• Publié par: Saunders
• Date de parution: 28 avril 2012
• Nombre de lectures: 0
• EAN13: 9781455744299
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Positron Emission Tomography Clinics , Vol. 7, Suppl., 2011
ISSN: 1556-8598
doi: 10.1016/S1556-8598(12)00042-9

Contributors
Positron Emission Tomography Clinics
PET Imaging of Infection and Inflammation
Abass Alavi, MD
Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Hongming Zhuang, MD, PhD
Division of Nuclear Medicine, Department of Radiology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
ISSN  1556-8598
Volume 7 • Number 2 • April 2012

Table of Contents
Cover
Contributors
Forthcoming Issues
CME Accreditation Page and Author Disclosure
PET Imaging of Infection and Inflammation
Promising Roles of PET in Management of Arthroplasty-Associated Infection
FDG PET and PET/CT Imaging in Complicated Diabetic Foot
FDG PET Assessment of Osteomyelitis: A Review
Fever of Unknown Origin: The Roles of FDG PET or PET/CT
PET/CT in Patients with Sarcoidosis or IgG4 Disease
Utilization of FDG PET/CT in the Management of Inflammation and Infection in Patients with Malignancies
The Utility of FDG PET/CT in Inflammatory Bowel Disease
FDG PET Imaging of Large-Vessel Vasculitis
Assessment of Therapy Response by FDG PET in Infection and Inflammation
Index
Positron Emission Tomography Clinics , Vol. 7, Suppl., 2011
ISSN: 1556-8598
doi: 10.1016/S1556-8598(12)00044-2

Forthcoming Issues
Positron Emission Tomography Clinics , Vol. 7, Suppl., 2011
ISSN: 1556-8598
doi: 10.1016/j.cpet.2012.03.001
CME Accreditation Page and Author Disclosure

Goal Statement
The goal of the PET Clinics is to keep practicing radiologists and radiology residents up to date with current clinical practice in positron emission tomography by providing timely articles reviewing the state of the art in patient care.

Accreditation
PET Clinics is planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the University of Virginia School of Medicine and Elsevier. The University of Virginia School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.
The University of Virginia School of Medicine designates this enduring material activity for a maximum of 15 AMA PRA Category 1 Credit(s )™ for each issue, 60 credits per year. Physicians should only claim credit commensurate with the extent of their participation in the activity.
The American Medical Association has determined that physicians not licensed in the US who participate in this CME enduring material activity are eligible for a maximum of 15 AMA PRA Category 1 Credit(s )™ for each issue, 60 credits per year.
Credit can be earned by reading the text material, taking the CME examination online at http://www.theclinics.com/home/cme , and completing the evaluation. After taking the test, you will be required to review any and all incorrect answers. Following completion of the test and evaluation, your credit will be awarded and you may print your certificate.

Faculty Disclosure/Conflict of Interest
The University of Virginia School of Medicine, as an ACCME accredited provider, endorses and strives to comply with the Accreditation Council for Continuing Medical Education (ACCME) Standards of Commercial Support, Commonwealth of Virginia statutes, University of Virginia policies and procedures, and associated federal and private regulations and guidelines on the need for disclosure and monitoring of proprietary and financial interests that may affect the scientific integrity and balance of content delivered in continuing medical education activities under our auspices.
The University of Virginia School of Medicine requires that all CME activities accredited through this institution be developed independently and be scientifically rigorous, balanced and objective in the presentation/discussion of its content, theories and practices.
All authors/editors participating in an accredited CME activity are expected to disclose to the readers relevant financial relationships with commercial entities occurring within the past 12 months (such as grants or research support, employee, consultant, stock holder, member of speakers bureau, etc.). The University of Virginia School of Medicine will employ appropriate mechanisms to resolve potential conflicts of interest to maintain the standards of fair and balanced education to the reader. Questions about specific strategies can be directed to the Office of Continuing Medical Education, University of Virginia School of Medicine, Charlottesville, Virginia.
The faculty and staff of the University of Virginia Office of Continuing Medical Education have no financial affiliations to disclose.
The authors/editors listed below have identified no professional or financial affiliations for themselves or their spouse/partner:
Abass Alavi, MD, PhD (Hon), DSc (Hon) (Consulting and Guest Editor); Sarah Barth, (Acquisitions Editor); Sandip Basu, MBBS (Hons), DRM, DNB, MNAMS; Qi Cao, MD, PhD; Wengen Chen, MD, PhD; Ion Codreanu, MD, PhD; Phyllis Dioguardi, MD, MA; Mohan Doss, PhD, MCCPM; Santosh R. Gaddam, MD; Roland Hustinx, MD, PhD; Sellam Karunanithi, MD; Rakesh Kumar, MD, PhD; Yuejian Liu, MD; Molly Parsons, BA; Patrice Rehm, MD (Test Author); Babak Saboury, MD, MPH; Sabah Servaes, MD; Drew A. Torigian, MD, MA; Bing Xu, MD, PhD; Jigang Yang, MD, PhD; Hongming Zhuang, MD, PhD (Guest Editor); and Pouya Ziai, MD.
The authors/editors listed below identified the following professional or financial affiliations for themselves or their spouse/partner:
Jian Q. Yu, MD, FRCPC is an industry funded research/investigator for Siemens.
Disclosure of Discussion of Non-FDA Approved Uses for Pharmaceutical Products and/or Medical Devices
The University of Virginia School of Medicine, as an ACCME provider, requires that all faculty presenters identify and disclose any off-label uses for pharmaceutical and medical device products. The University of Virginia School of Medicine recommends that each physician fully review all the available data on new products or procedures prior to clinical use.

To Enroll
To enroll in the PET Clinics Continuing Medical Education program, call customer service at 1-800-654-2452 or visit us online at www.theclinics.com/home/cme . The CME program is available to subscribers for an additional fee of $196.00.
Positron Emission Tomography Clinics , Vol. 7, Suppl., 2011
ISSN: 1556-8598
doi: 10.1016/j.cpet.2012.02.001

CME
Preface
PET Imaging of Infection and Inflammation

Abass Alavi, MD, PhD (Hon), DSc (Hon)
Division of Nuclear Medicine, Department of Radiology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
E-mail address: [e-mail]
E-mail address: [e-mail]

Hongming Zhuang, MD, PhD
Division of Nuclear Medicine, Department of Radiology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
E-mail address: [e-mail]
E-mail address: [e-mail]

Abass Alavi, MD, PhD (Hon), DSc (Hon), Guest Editor
Hongming Zhuang, MD, PhD, Guest Editor
The introduction of 18F-fluoro-2-deoxglucose (FDG) in 1976 as a joint effort between investigators at the University of Pennsylvania and Brookhaven National Laboratory opened a new era in medical imaging. Although the initial intent of scientists involved in this project was to determine central nervous system function in normal and diseased states, FDG has proven to be of great value in many other domains over the last three decades. Soon after its introduction, FDG was employed to characterize brain tumors, particularly when the differential diagnosis of tumor recurrence versus radiation-induced necrosis was of clinical concern. With the introduction of whole body imaging, numerous malignancies were examined with FDG for accurate diagnosis, staging, response to therapy, and recurrence. In fact, this application has become the most valuable contribution of this agent to the practice of medicine. However, with a wider spread utilization of this methodology, it became apparent that inflammatory reactions due to either underlying infection or autoimmune disorders are readily detected by this technique.
Investigators at various laboratories around the world including those at the University of Pennsylvania have heavily researched the role of FDG-PET in assessing infection and inflammation in a variety of settings. In the past decade, a large number of scientific communications have appeared in the literature, substantiating the role of this very powerful modality in these common disorders. Attempts have been made to secure reimbursement from Medicare and Medicaid for this particular application. Unfortunately, limited experience in the United States utilizing FDG for this particular domain has resulted in delays of approval. However, in Europe and other countries, FDG is being frequently used for examining patients with a variety of inflammatory reactions. In this issue of the PET Clinics , we have updated the current literature on this topic and hope that educating the community of the potential for this very important application of FDG will