Soft Tissue Pathology: Diagnostic Challenges, An Issue of Surgical Pathology Clinics

Leona A. Doyle

Description

This issue of Surgical Pathology Clinics is devoted to Soft Tissue Tumors, the first in this series was presented in 2011. This issue addresses the most difficult diagnostic challenges and focuses on differential diagnosis in soft tissue tumors. Each presentation is accompanied by abundant histologic slides to display the diagnostic differences. Additionally, authors selected two to five diagnoses they find can be particularly difficult, with an emphasis on how to approach such lesions on biopsy samples where relevant and the role of ancillary studies. Topics include coverage of diagnostically challenging: Vascular lesions; Retroperitoneal “Fatty tumors of adults; Smooth muscle neoplasms; Chondro-osseous lesions of soft tissue; Pediatric tumors; Epithelioid tumors; Spindle cell neoplasms of the retroperitoneum; and Peripheral nerve sheath tumors. Also presented are: Non-mesenchymal mimics of benign and malignant soft tissue tumors; Soft tissue tumors with overlapping molecular findings; Recently characterized soft tissue tumors; Benign mimics of sarcoma; Advances in molecular methods in the analysis of soft tissue tumors and therapeutic implications; and Myoepithelial tumors: an update. Leona Doyle and Karen Fritchie lead this issue of experts in soft tissue pathology.

Sujets

• Medical
• Médecine
• Pathology

Informations

• Publié par: Elsevier
• Date de parution: 23 novembre 2015
• Nombre de lectures: 0
• EAN13: 9780323402750
• Langue: English
• Poids de l'ouvrage: 5 Mo

Extrait

Clinics Review Articles Surgical Pathology Clinics
Soft Tissue Pathology: Diagnostic Challenges

Leona A. Doyle, MD
Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts, USA

Karen J. Fritchie, MD
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
ISSN  1875-9181 Volume 8 • Number 3 • September 2015
Elsevier
Table of Contents
Cover image
Title page
Copyright
Contributors
Consulting Editor
Editors
Authors
Forthcoming Issues
Forthcoming Issues
Recent Issues
Preface: Diagnostic Challenges and Recent Developments in Soft Tissue Pathology
Diagnostically Challenging Epithelioid Soft Tissue Tumors
Abstract
Overview
Epithelioid sarcoma
Alveolar soft part sarcoma
Clear-cell sarcoma
Ossifying fibromyxoid tumor
Malignant extrarenal rhabdoid tumor
Diagnostically Challenging Epithelioid Vascular Tumors
Abstract
Overview
Epithelioid hemangioma
Cutaneous epithelioid angiomatous nodule
Epithelioid hemangioendothelioma
Epithelioid sarcomalike hemangioendothelioma (pseudomyogenic hemangioendothelioma)
Epithelioid angiosarcoma
Summary
Diagnostically Challenging Spindle Cell Neoplasms of the Retroperitoneum
Abstract
Overview
Dedifferentiated liposarcoma
Cellular schwannoma
Malignant peripheral nerve sheath tumor
Deep leiomyoma
Leiomyosarcoma
Mammary-type myofibroblastoma
Summary
Diagnostically Challenging “Fatty” Retroperitoneal Tumors
Abstract
Overview
Pattern 1: mature adipose tissue and atypical hyperchromatic stromal cells
Pattern 2: mature adipose tissue without cytologic atypia
Pattern 3: mature adipose tissue with atypical hyperchromatic stromal cells admixed with undifferentiated pleomorphic sarcoma
Pattern 4: mature adipose tissue with low-grade spindle-cell proliferation
Pattern 5: myxoid sarcoma with a fatty component
Summary
Selected Diagnostically Challenging Pediatric Soft Tissue Tumors
Abstract
Superficial Ewing sarcoma: Overview
Poorly differentiated chordoma
Nasal chondromesenchymal hamartoma
Chondro-Osseous Lesions of Soft Tissue
Abstract
Overview
Myositis ossificans and related tumors
Ossifying fibromyxoid tumor
Extraskeletal osteosarcoma
Soft tissue chondroma
Radiographic features
Gross features
Microscopic features
Synovial chondromatosis
Mesenchymal chondrosarcoma
Extraskeletal myxoid chondrosarcoma
Myoepithelial Tumors
Abstract
Overview
Myoepithelioma and myoepithelial carcinoma
Mixed tumors of soft tissue and skin
Cutaneous syncytial myoepithelioma
Myoepithelial tumors of bone
The New Kids on the Block
Abstract
Overview
Superficial CD34-positive fibroblastic tumor
Fibrosarcoma-like lipomatous neoplasm
Angiofibroma of soft tissue
Low-grade sinonasal sarcoma with neural and myogenic features
Malignant gastrointestinal neuroectodermal tumor
Hemosiderotic fibrolipomatous tumor
Epithelioid inflammatory myofibroblastic sarcoma
Recent molecular findings in soft tissue tumors
Non-mesenchymal Mimics of Sarcoma
Abstract
Overview
Malignant melanoma
Carcinoma types that may mimic sarcoma (and vice versa)
Hematolymphoid neoplasms
Malignant mesothelioma
Summary
Genetics of Gastrointestinal Stromal Tumors
Abstract
Overview
Genotypes of gastrointestinal stromal tumor
KIT mutations
Platelet-derived growth factor receptor ALPHA mutations
Familial gastrointestinal stromal tumor syndrome
So-called KIT/platelet-derived growth factor receptor ALPHA–wild-type gastrointestinal stromal tumors
Succinate dehydrogenase B–deficient gastrointestinal stromal tumors
BRAF-mutated gastrointestinal stromal tumors
Neurofibromatosis type 1-associated gastrointestinal stromal tumors
“Quadruple wild-type” gastrointestinal stromal tumors
Summary
Advances in the Molecular Analysis of Soft Tissue Tumors and Clinical Implications
Abstract
Overview
Applications of massively parallel sequencing technologies
Non–sequencing-based high-throughput molecular techniques
Low-throughput technologies
Drug target identification
Concluding remarks
Copyright
ELSEVIER
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SURGICAL PATHOLOGY CLINICS Volume 8, Number 3 September 2015 ISSN 1875-9181, ISBN-13: 978-0-323-40274-3
Editor: Lauren Boyle
Developmental Editor: Donald Mumford
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Contributors

Consulting Editor
JOHN R. GOLDBLUM, MD
Chairman, Department of Anatomic Pathology, Professor of Pathology; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, Ohio

Editors
LEONA A. DOYLE, MD
Associate Pathologist, Department of Pathology, Brigham and Women’s Hospital; Assistant Professor of Pathology, Harvard Medical School, Boston, Massachusetts
KAREN J. FRITCHIE, MD
Assistant Professor, Department of Laboratory Medicine and Pathology, Mayo