Tadalafil bulk supplier CAS 171596-29-5 dosage, side effect

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Tadalafil bulk supplier CAS 171596-29-5 dosage, side effect

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• Publié par: dorin2000
• Publié le: 24 novembre 2018
• Nombre de lectures: 2
• Poids de l'ouvrage: 1 Mo

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Phcokerwww.phcoker.com Tadalafil bulk supplier CAS 171596-29-5 dosage, side

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Erectile dysfunction (ED) has become a common health issue amo ngst men, especially those who’ve hit 40. A recent research shows that 5% of men aged 4 0 years suffer from complete erectile dysfunction. The percentage increases to 15 for 70 years-old men. To address this problem, scientists have come up with various med ications aimed at helping men maintain their masculinity with proper erection capabi lity. Tadalafil (CAS 171596-29-5) is one of the most prominent ED treatment medications.

What is Tadalafil (171596-29-5)? ♦ Brand name: Cialis, Adcirca, etc.

♦ Chemical structure of Tadalafil

Tadalafil is a FIDA-approved oral drug used for the treatment of ere ctile dysfunction or impotence among men. It functions similarly to similar to Via gra and Levitra by increasing the flow of blood to the penis and as a result, enables a man to ge t an erection. It is suitable for adult men who have difficulties in attaining or maintaining a penile erection.

♦ Tadalafil history

Galxo Wellcome, in collaboration with Lilly ICOS, a biotechn ology company, was the first to discover and develop Tadalafil. However, the companies p arted ways in 1996 and two years later, ICOS Corporation and Eli Lilly entered a joint vent ure and formed a new

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Phcokerwww.phcoker.com company called Lilly ICOS, LLC. The venture developed the dru g again and started to sell it as Cialis.

After a few years, Lilly ICOS, LLC. filed a new application fo r the drug with Tadalafil as the generic name and Cialis as the brand name. December 2003 was a hi storic moment for Tadalafil as it is the time that it was approved by the Food and Drug Administration (FDA) for sale in the United States as a drug for erectile dysfunction treatment.

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Tadalafil (171596-29-5) — How does it work? Men with ED usually have an enzyme called PDE5. This enzyme su ppresses cyclic guanosine monophosphate (cGMP), an extremely important substa nce in the processing of a healthy penile erection. cGMP helps a man’s nerve ending si gnals in the pelvic region to trigger nitric oxide release. As a result, the smooth lin ings of his pelvic blood vessels relax and this leads to increased blood flow through th e vessels to fill the cavernous structures of his penile body. This makes the penis to become hard and engorged.

Higher amounts of PDE5 and insufficient cGMP in a man make his body unable to decipher the signals released by his nerve endings, leading to partial or complete loss of ability to get a penile erection. Men with erection problems hav e low blood flow to their penises. Since a penis becomes hard as a result of increased supp ly, such men cannot get an erection due to lack of insufficient blood in their peni ses.

When a man with penile erection incapability takes Tadalafil (171596-29-5) as prescribed, the drug reduces the effects of PDE5 in his body system and this m akes cGMP concentration to return usual level. Just like other erectile dy sfunction drugs, Tadalafil works by widening a man’s blood vessels and as a result, when sex ually stimulated, the blood flow to his penis increases, the organ becomes hard, henc e an erection.

Although the medication acts similarly to Viagra, Spedra and Le vitra its effect lasts longer- up to 36 hours. No wonder it is called a weekend pill, simply be cause a single dose of the drug can make a man with ED have a normal erection and enjoy sexual intercourse with his partner for nearly a whole weekend.

When a man takes a 36-hour Tadalafil dose, the drug reduces the P DE5 level in his body quickly (in about 15 to 45 minutes) and as a result, cGMP returns to normal levels. Nevertheless, since the medication has a relatively short half -life, its effect disappears within two days and as a result, the level of PDE5 increases agai n and the man loses his

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On the other hand, when a man is taking dailyTadalafildose for ED treatment, the drug helps in keeping cGMP in his body in healthy levels all the tim e as long as he adheres to the drug’s prescription religiously. This helps the man to get an erection easily whenever he’s sexually stimulated. However, the daily dose of low-st rength Tadalafil usually takes 4 to 5 days to begin working. So, don’t be in a hurry to become a bed t iger upon taking the first pill; just let the period lapse and you’ll be just that as long as you take it as prescribed.

Tadalafil– How should I do when I want to take Tadalafil? Being a prescription-only medication, a man ought to be extra cau tious while planning to take it. Particularly, he ought to do and observe various things b efore, when and after taking it.

Let’s start with the things that one should do before taking the drug.

Do the following before taking Tadalafil: ♦ Visit a doctor or pharmacist for advice on the right Tadalafi l dosage for you, among other prescription information.

♦ In case you are allergic to certain medications, including Tad alafil itself or some of its ingredients, let the doctor or pharmacist know about it. You ca n get information about the ingredients of the drug from the medical expert.

♦ Let your doctor know in case you have taken riociguat or nitrat es isosorbide dinitrate and nitroglycerin in the recent past or still on them. You can con firm from the doctor or

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Phcokerwww.phcoker.com pharmacist if the drugs you are using (if any) have nitrated. You might be advised not to take Tadalafil if the doctor finds out that you are taking nitra tes because they don’t get along well with Tadalafil.

♦ Remember thatTadalafilcomes with a brand name Adcirca or Cialis. Therefore, you should not take both concurrently, otherwise, you’ll have abus ed the drug and the outcome might be undesirable. You should only be treated with a ny of them at a time.

♦ Are you taking (or planning to take) any other medication, be i t prescription or nonprescription, vitamins or nutritional supplements? If yes , bring it to the attention of the medical expert. Such information is crucial as it’ll help the do ctor or pharmacist to establish the dosage that will be best for you, considering th e other medication or supplements that you are using or intend to use. Upon having th e information, the specialist may find it necessary to monitor you closely for p ossible side effects.

♦ Are you using any herbal product, particularly St. John’s wort? I f yes, let the specialist know about it.

♦ In case you are a smoker and at one or several occasions have eve r had an erection that persisted for over four hours, you need to tell your docto r or pharmacist about it.

♦ Tell your doctor if you have vomited, sweated abnormally, ha d diarrhea, or not been taking sufficient water and so you suspect that you might be i nsufficiently hydrated.

♦ Let your doctor know if you have ever suffered from the pulmona ry veno-occlusive disease in your life or any other health condition that’s lik ely to affect the shape of your penis. Such conditions include diabetes, high or low blood p ressure, heart attack/failure, blood circulation issues, blood cell issues, irregular heartb eat, chest pain, multiple myeloma, stomach ulcers, bleeding disorders, a heart disease , a kidney disease, a liver disease and stroke

♦ If you love alcoholic beverages and you’d like to use them whi le taking Tadalafil, you need to discuss with your doctor about it. Upon an assessment of your health, your doctor will advise you accordingly, whether to avoid the drinks or tak e them moderately. In the case of wine or whiskey, you might be advised to take not more th an five glasses. This is because high alcohol intake while one is on the effects of Tad alafil can cause side effects like low blood pressure, increased heartbeat rate, headache as w ell as dizziness.

♦ In case you had previously been advised by a health specialis t to refrain from having sexual intercourse due to a medical reason, you should bring it to the attention of your doctor.

♦ Tell your doctor if you have ever had chest pain while performi ng a sexual activity. Your heart may be strained as a result of your engagement in a sexual a ctivity, particularly if

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Phcoker you are suffering from a heart illness.

♦ Tell your doctor if you’re prostrate or part of it has been removed .

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You should not take Tadalafil in case: ♦ You have ever had a vision-impairing condition called Non-art eritic anterior ischemic optic neuropathy (NAION)

♦ You suffer from a heart illness

♦ You have suffered from stroke or a heart attack, recently, partic ularly in the last six months

♦ You are suffering from low blood pressure

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♦ Allergic to the ingredients of Tadalafil

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♦ Bear in mind that the effect of the drug might not be instant. A lthough 36-hour dose gives the desired Tadalafil results faster as compared to a daily dose , you are likely to wait for about 15 to 45 minutes to feel the desired effect of the drug.

♦ Don’t take nitrates for at least 48 hours before the time you are expecting to take Tadalafil.

♦ Get Tadalafil from a trusted source. You can count on Phcoker.c om for genuine Cialis products, including Tadalafil.

While taking Tadalafil ♦ Once your doctor has found that you are fit to use Tadalafil an d prescribes you the right dose for the treatment of ED, there are various things that you ou ght to do while taking the medications. Here is a list of the dos and the don’ts:

♦ Ensure that you adhere fully to the dosage instruction given by your doctor. Take the medication precisely the way the specialist advised you. You are supposed to take the drug at least half an hour prior to the time you have planned to en gage in sexual intercourse.

♦ Swallow the tablet whole with a drink of water. You can take it with or without food. Do not drink an excessive amount of alcohol while taking the medi cation, as this increases your risk of side effects such as dizziness when you stand up.

♦ Avoid drinking grapefruit juice, eating grapefruit or using grap efruit products while you are taking Tadalafil since grapefruit content can interfere with the effectiveness of the medication.

♦ You should also avoid taking alcohol while using the ED medi cation. The reaction of the drug and alcohol can make you experience some side effects.

♦ You should take the drug strictly as per the amount recommended by the doctor; not more, not less.

♦ Don’t take the medication for a longer period than prescribed.

♦ You can take Tadalafil with or without food

♦ Swallow the Tadalafil tablet whole with a mouthful of water; do not break or split the tablet.

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♦ You should take Tadalafil before having sex and not more than one time in a day.

♦ You must necessarily be on a dosage schedule of the medicatio n. Therefore, just take it as prescribed by the medical expert.

♦ In case you’ve missed a dose, don’t take extra Tadalafil to ma ke up. If you missed, just let it go just like that and continue taking as prescribed.

After takingTadalafil ♦ Make sure you are sexually stimulated if you want to erect and en joy sex because the drug will only be effective if you are stimulated sexually.

♦ In case you are due for a surgery, even the least serious like dent al surgery and you have taken Tadalafil; tell your doctor or surgeon about it prio r to the operation.

In case you have recently taken Tadalafil or still on its course and you need emergency heart problem medical treatment, let your health care provider k now about it as well. Tadalafil reacts to heart medications and so, upon revealing s uch information to your health specialist, they’ll be able to establish the safest c ourse of action, considering the possible effectiveness of Tadalafil in your body. Therefore, your doctor will be interested in knowing when you last took the medication.

♦ Make sure that you keep the medication at a room temperature, in a cool and dry place; away from heat and moisture.

Tadalafil– What is it’s side effects? Although Tadalafil is very effective as an ED treatment, it can cause some undesired effects. Although a man who has taken the medication is not li kely to experience all these side effects, he should seek medical attention in case he exp eriences some of them.

▲ The side effects that must require doctor’s attention king the medication since some of them can be fatal if they are u naddressed on time.

A: The Common side effects In this case, the common side effects include:

Arm pain Jaw pain Back pain Neck pain Leg pain Upset stomach Stuffy nose/ nasal congestion

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Phcokerwww.phcoker.com Unclear sight Chest pain Chest discomfort Tight chest Heavy chest Chills Confusion Nausea Headache Irregular heartbeat Slow heartbeat Fast heartbeat Cold sweats Loss of hearing capability Faintness or lightheadedness while getting up quickly from a lying/sitting position Dizziness Passing out Nausea Anxiety Abnormal exhaustion or weakness Vomiting Warmth, redness, or tingly sensation Swollen lips, tongue or throat Ringing in your ears B: Rare side effects (1) With a severe expression Although the following Tadalafil side effects are rare, they mo stly have a severe expression if they occur.

Painful or prolonged penis erection Unusual liver function tests Blocked or closed eye retina blood vessels Anal blood discharge Reduced blood pressure when you stand Swallowing difficulties Angina Unusually low blood pressure Eye disease as a result of blood flow issues Heart attack Heart throbbing or pounding Inflamed esophagus Kidney disease and reduced kidney function Sudden loss of vision Pink eye

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Phcoker Swollen face Skin rash and skin sloughing Stevens – Johnson syndrome Stroke Breathing difficulties

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(2) Less Severe expression The following are also rare side effects of Tadalafil (171596-29-5 ) but they have a less severe expression as compared to the previously listed.

Fluid accumulation in the eyelid tissues A burning sensation in the stomach Chronic sleep issues Acquired abnormally colored sight Abnormal mouth dryness Short-term memory loss episodes Too much sweating Excessive watery eyes Fluid accumulation in the legs, hands, feet or arms Hives Itchiness Too much blood in the eye lining Painful joints Loose stools Regular erections Nosebleed Numbness Tingling Painful eyes Rash A spinning or whirling feeling The above list doesn’t comprise all the side effects of the drug s. Therefore, you are advised to get comprehensive information about all the possib le effects from your doctor. In case you experience another side effect that is not listed h ere, you can report it to FDA at 1-800-FDA-1088.

▲ The side effects that don’t require doctor’s attention A Tadalafil side effect must not require medical attention to g o away. Some go away by themselves once your body gets used to the medication. Besid es, your health care provider may advise you on how to prevent or minimize such effec ts. However, you can still check with your health specialist if they are persistent or bothering you much. Some of these side effects are more common than others. Let’s start wi th the more common:

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Phcokerwww.phcoker.com A: More-common self-healing side effects Acid or sour stomach Heartburn Stomachache Stomach discomfort Stomach upset Belching Indigestion B: Less-common self-healing side effects These Tadalafil side effects go away on their own without any medical intervention but they are less-common.

Bloody nose Numbness Itchiness Prickling, “pins and needles”, tingling, crawling and burning s ensations Painful, burning or dry eyes Nasal congestion Dry or a sore throat Excessive tiredness Loose stools Muscle cramps and aches Stiff muscles Neck, arm and/or leg pain Painful or burning throat Painful, swollen or reddened eyes, eyelid or eyelid’s inner l ining Reduced sensitivity to touch Spinning sensation Dizziness or unusual drowsiness Lack of sleep Impulsive erection of the penis Stomach upset Puffy or swollen face Swelling of joints Upper abdominal or stomach pain Hoarse voice Watery eyes

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Tadalafil– What are the application forms of Tadalafil? Tadalafil comes in the form of tablets, liquid or. Whichever f orm in which you take the medication, rest assured that it is as effective as the medicat ion in any of the two other forms. Liquid Tadalafil is similarly effective as or tablet Ta dalafil as long as you’ve bought the medication from a trusted source. Although there might be a di fference, it should be fairly insignificant.

♦ Tadalafil pills or tablets As earlier mentioned Tadalafil comes as tablets, pills liqui d or. Tadalafil tablets or pills are yellow in colour, coated with a film and are almond-shaped. T hey are sold in 2.5, 5mg, 10mg and 20mg doses.

The tablets come in packets of 5, 10, 15, 30 and 90 tablets each . You can also get the medication as a 4, 8, 12, 16 or 28 tablet packet.

Tadalafil tablets for daily use comes in 2.5 mg and 5 mg doses w hile the 10mg dose is used only when a man is about to have sex; at least 30 minutes be fore engaging in a sexual intercourse. Considering the effectiveness of the drug i n a man and his tolerability to the medication, the doctor may prescribe the on as-needed dosage to be increased to 20 mg or reduced to 5 mg. The 5mg when-needed dose is s uitable for men with less-severe ED.

The recommended daily Tadalafil dose is usually 2.5 mg and oug ht to be taken as at a specific time every day. However, depending on the efficacy a nd tolerability, the dosage may be increased to 5 mg.

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