DNA Blood Test Detects Cancer Resistance Using Inostics' BEAMing Technology

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• Publié par: inostics-gmbh
• Nombre de lectures: 14
• Langue: English

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DNA Blood Test Detects Cancer Resistance

Using Inostics' BEAMing Technology

PR Newswire

BALTIMORE, Maryland and HAMBURG, Germany, June 18, 2012

BALTIMORE, Maryland

and

HAMBURG, Germany

,

June 18, 2012

/PRNewswire/ --

Two studies published back-to-back in last week's

Nature

applied DNA blood

testing using the BEAMing technology to detect drug resistance mediated by

KRAS mutations in colorectal cancer patients months before treatment failure

was observed.

The group led by Alberto Bardelli, PhD of the University of

Torino, Italy

describes the development of secondary resistance mutations to the anti-EGFR

monoclonal antibody cetuximab (Erbitux®) in patients with metastatic

colorectal cancer (mCRC) [Misale S.

et al.,

Nature Epub

13 June 2012

]

.

The

second group led by Luis Diaz, MD and Bert Vogelstein, MD from Johns Hopkins

University reached similar conclusions after studying mCRC patients treated

with a monotherapy of panitumumab (Vectibix®) [Diaz Jr LA

et al.,

Nature Epub

13 June 2012

].

Both teams concluded that blood-based noninvasive monitoring of patients

undergoing targeted therapy could provide significant benefits by allowing for

early intervention with additional treatment options that may delay or prevent

disease progression.

The BEAMing technology is a combination of digital PCR and flow cytometry

originally developed by the group of Bert Vogelstein, MD. Inostics licensed the

technology from the Johns Hopkins University and automated it for routine use.

BEAMing is the most sensitive and quantitative technology available today for

the detection of tumor specific somatic mutations in blood samples. Inostics'

BEAMing services are readily available to support clinical trials and research in

oncology. Furthermore, Inostics will offer BEAMing as a CLIA certified test for

routine analysis.

For more information on blood testing and the BEAMing Digital PCR technology

refer to http://www.inostics.com or email us at [e-mail].

Please contact:

Inostics

Friederike Lehmann, PhD

Marketing & Licensing

Phone [phone]

Fax

[phone]

[e-mail]

http://www.inostics.com