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Description

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• Publié par: dorin2000
• Publié le: 17 juillet 2018
• Nombre de lectures: 1

Extrait

Levonorgestrel:

Content

How

it

works,

uses,

side

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effects-AASraw

............................................................................................................... Levonorgestrel: How it works, uses, side effects-AASraw 1 .................................................................................................................................................................. 1. What is Levonorgestrel powder? 1 ................................................................................................................................................................................... 2. Levonorgestrel Benefits 3 ................................................................................................................................................................... 3. How does Levonorgestrel work? 5 ................................................................................................................................... 4. What dosage of levonorgestrel you should take? 6 ............................................................................................................ 5. What you should to follow if missed Levonorgestrel dosage ? 7 ............................................................................................................................................ 6. What are the side effects of levonorgestrel? 8 ......................................................................................................................... 7. What you should know before using Levonorgestrel? 11

1. What is Levonorgestrel powder?

Levonorgestrel powder is a

a progestin that is used as contra ception, sold under the

brand name Plan B among others. It is useful within 120 hours a s emergency birth

control after unprotected sex or

after failure of another bi rth control method(such as

condom breakage, or missing 2 or more birth control pills). I t works by preventing a

woman's egg from fully developing. It may also prevent the at tachment of the woman's

egg to the wall of the uterus. but it will not prevent the sprea d of human

immunodeficiency virus (HIV, the virus that causes acquire d immunodeficiency

syndrome [AIDS]) and other sexually transmitted diseases.

Levonorgestrel CAS:

797-63-7 is marketed mostly as a combination oral contracep tive under several brand

names such as Alesse, Triphasil, and Min-Ovral. It is effect ive for long-term prevention of

pregnancy.

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Chemical name:

CAS:

EINECS:

Molecular Formula:

Molecular Weight:

Purity:

Synonyms:

Melting point:

Boiling Point:

Flash Point:

Storage Temp:

Color:

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Levonorgestrel powder

797-63-7

212-349-8

C21H28O2

312.45

99%min

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13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3 -one ;

13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one ;

13-ethyl-17-hydroxy-19-dinor-17-alpha-pregn-4-en-20-yn-3-on(+)-1 ;

17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one ;

17-beta-hydroxy-18-methyl-19-nor-17-alpha-pregn-4-e n-20-yn-3-on ;

17-ethynyl-18-methyl-19-nortestosteron ;

17-ethynyl-18-methyl-19-nortestosterone ;

18-methyl-17-alpha-ethynyl-19-nortestosterone

206°C

459.1°C at 760 mmHg

195.4°C

2-8°C

White crystalline powder

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2. Levonorgestrel Benefits

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Levonorgestrel CAS: 797-63-7 gives the users many non-cont raceptive benefits: the

amount of menstrual bleeding and the number of days of menstr ual bleeding are

reduced, which makes it suitable for the treatment of menorr hagia (heavy menstrual

blood loss).

Dysmenorrhoea (painful menstruation) and premenstrual sy mptoms are also relieved. In

addition, Levonorgestrel provides protection for the endo metrium during hormone

replacement therapy. The local release of levonorgestrel i nto the uterine cavity results in

a strong uniform suppression of the endometrial epithelium as the epithelium becomes

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insensitive to estradiol released from the ovaries. This ac counts for the reduction in

menstrual blood loss. All possible patterns of bleeding are seen among users of

Levonorgestrel; however, most of the women who experience t otal amenorrhoea

continue to ovulate. The first months of use are often charac terised by irregular, scanty

bleeding, which in most cases resolves spontaneously. The m enstrual pattern and

fertility return to normal soon after Levonorgestrel is rem oved. The contraceptive

efficacy is high with 5-year failure rates of 0.5-1.1 per 100 users. The absolute number of

ectopic pregnancies is low, as is the rate per 1000 users. Lev onorgestrel is equally

effective in all age groups and the bodyweight of the user is n ot associated with failure

of the method. In Western cultures continuance rates among u sers of

Levonorgestrel

CAS: 797-63-7 are comparable with those of o ther long-term methods

of contraception. Premature removal of the device is most of ten associated with heavy

menstrual bleeding and pain, as with other long-term method s of contraception, and is

most common in the youngest age group. When adequately couns elled about the

benign nature of oligo- or amenorrhoea, most women are very w illing to accept life

without menstruation. The risk of premature removal can be m arkedly diminished with

good pre-insertion counselling, which also markedly incre ases user satisfaction. User

satisfaction is strongly associated with the information g iven at the time of

Levonorgestrel insertion. Thus, the benefits of the levono rgestrel make it a very suitable

method of contraception for most women.

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3. How does Levonorgestrel work?

Levonorgestrel CAS: 797-63-7

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comes as a tablet to take by mou th. If you are taking

levonorgestrel as a single tablet product , take one tablet a s soon as possible within 72

hours (3 days) after unprotected sexual intercourse. If you are taking levonorgestrel as a

two tablet product, take one tablet as soon as possible withi n 72 hours after unprotected

sexual intercourse and take a second dose 12 hours later. Lev onorgestrel works best if it

is taken as soon as possible after unprotected sexual interc ourse. If you vomit less than

2 hours after you take a dose of levonorgestrel, contact your doctor to ask if you need

to repeat the dose. After you take this medication, the time w hen your period comes and

how much you bleed may change. Tell your doctor right away if y our period is more than

7 days late. You may need to take a pregnancy test. If you are ta king the

over-the-counter product to self-treat, read all directio ns on the product package before

taking this medication. If you have any questions, talk to yo ur pharmacist. If your doctor

has prescribed this medication, take it as directed. This me dication may not work well in

women over a certain weight (for example, greater than 164 po unds or 74 kilograms), or

if you have used certain other medications within the past mo nth. This effect can result

in pregnancy. Talk to your doctor for more details and to see i f this medication is right

for you (see also Drug Interactions section).

Levonorgestrel CAS: 797-63-7 may be prescribed for other us es. Ask your doctor or

pharmacist for more information.

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4. What dosage of levonorgestrel you should take?

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Levonorgestrel CAS: 797-63-7 comes in pill form and a dose of 1.5mg must be taken not

more than 72 hours after intercourse. It is most effective wi thin 24 hours.

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Single dose regimen: Take one 1.5 mg tablet as soon as possibl e within 72 hours of

unprotected sex or when birth control fails.

Two-dose regimen: Take one 0.75 mg tablet as soon as possible within 72 hours of

unprotected sex or when birth control fails, followed by a se cond 0.75 mg tablet 12

hours later.

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5. What you should to follow if missed Levonorgestrel dosage?

Read and follow these instructions carefully as missing dos age

will increases your risk

of becoming pregnant. and call your doctor if you have any que stions.

If you miss one active pill, take it as soon as you can. Then tak e your next pill at the

regular time. This means you may take two pills in one day. If y ou miss two active pills

in week 1 or 2, take two pills as soon as you can and two more pill s the next day.

Continue taking one pill a day until you finish the pack. Use a nother kind of birth control

for seven days after you miss a dose. If you miss two active pil ls in a row in Week 3: Day

1 start—Throw out the rest of your pills and start a new pack on the same day. Sunday

start—Continue taking one pill a day until Sunday, then thro w out the rest of the pack

and start a new pack that same day. If you miss three active pil ls in a row in Week 1, 2,

or 3, throw out the rest of the pack and start a new pack on the sa me day if you are a

Day 1 starter. If you are a Sunday starter, keep taking a pill e very day until Sunday. On

Sunday, throw out the rest of the pack and start a new pack that day. If you miss two or

more active pills, you may not have a period during the month. If you miss a period for

two months in a row, call your doctor because you might be preg nant. If you miss a

reminder pill, throw it away and keep taking one reminder pil l per day until the pack is

empty. The more pills you miss, the more likely you are to have bleeding.If you miss two

periods in a row, call your doctor for a pregnancy test before you take any more pills.

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Store Levonorgestrel CAS: 797-63-7 in a closed container at room temperature, away

from heat, moisture, and direct light.

6. What are the side effects of levonorgestrel?

Levonorgestrel CAS: 797-63-7 may cause some adverse effect s when used as an

emergency contraceptive. Check with your doctor or pharmac ist immediately if any of

the following side effects occur:

Common side effects of levonorgestrel can include:

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Fatigue

Dizziness

Depression

mild bloating

Liver problems

Weight changes

Allergic reactions

Breast tenderness

Headache or migraine

Loss of interest in sex

Abdominal or pelvic pain

Upset stomach; feeling or being sick

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Irregular vaginal bleeding or spotting

longer or heavier menstrual periods

stopping of menstrual bleeding

uterine bleeding between menstrual periods

Less serious side effects of levonorgestrel may include:

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headache, nausea, diarrhea, or stomach pain;

dizziness, tired feeling;

cramps

pale skin

Blurred vision

nervousness

slow or fast heartbeat

breast pain or tenderness;

troubled breathing with exertion

unusual tiredness or weakness

unusual bleeding or bruising

itching of the vagina or genital area

white or brownish vaginal discharge

thick, white vaginal discharge with mild or no odor

More serious side effects that do require medical attention can include:

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Genital sores

High blood pressure

Signs of pregnancy

Fever or flu-like symptoms

severe cramps or pelvic pain;

Severe or sudden headache

Severe abdominal pain

Sudden shortness of breath

Yellowing of the skin or eyes

Pain, swelling or warmth in the leg

pain during sexual intercourse;

Difficulty with talking, walking or balance

No menstrual period for six weeks during use

pale skin, weakness, easy bruising or bleeding;

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heavy or ongoing vaginal bleeding, vaginal sores, vaginal d ischarge that is

watery, foul-smelling discharge, or otherwise unusual;

severe pain in your side or lower stomach;

Swelling of face, lips, eyelids, tongue, hands and feet Alle rgic reactions such as

skin rash, itching, hives, or

swelling of the face, lips or tongue

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This is not a complete list of side effects and others may occu r. Tell your doctor or

pharmacist about any unusual or bothersome side effect. You may report side effects to

FDA at 1-800-FDA-1088.

7. What you should know before using Levonorgestrel?

Before using Levonorgestrel CAS: 797-63-7, the risks of tak ing Levonorgestrel must be

weighed against the good it will do. This is a decision you and your doctor will make. For

this medicine, the following should be considered:

Existing pregnancy—

Levonorgestrel should not be used if you are already pregnan t or planning a pregnancy

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