Basic Concepts Signaling Pathways

Jean - Paul Borg

Description

Niveau: Supérieur, Master, Bac+4
Cell Signaling Basic Concepts Signaling Pathways Pr. Jean-Paul Borg I N S T I T U T PAOLI-CALMETTES PR O V E N C E - A L P E S - C Ô T E D ' A Z U R CENTRE REGIONAL DE LUTTE CONTRE LE CANCER

• cell communication


• centre regional de lutte contre le cancer


• signaling pathways


• paoli-calmettes pr

Sujets

• Cell signaling
• Centre régional de lutte contre le cancer

Informations

• Publié par: larec
• Nombre de lectures: 6
• Langue: English
• Poids de l'ouvrage: 2 Mo

Extrait

Cell Signaling

BasicConcepts SignalingPathways

Pr. Jean-Paul Borg

I N S T I T U T CENTRE REGIONAL DE LUTTE CONTRE LE CANCER PAOLI-CALMETTES P R O V E N C E - A L P E S - C Ô T E D ' A Z U R

Introduction

- Cell communication: a fundamental feature of pluricellular organisms

- Responses: cell proliferation, cell migration, apoptosis, cell differentiation

- Short or long distance

- Ligands: peptides, proteines, gaz

- Pathologies

Introduction

Principles of information transmission

Goalofsignaling pathwaysisto ensurean appropriate reactiontothe typeand strengthof anextracelualr stimulus

growth

proliferation

death

necrosis apoptosis

Environmental input

processing

reaction



EFFECTOR FUNCTIONS

movement

Generate new information   nssoisnimtoarenru  menesssreg

A Model of Receptor-mediated Signal Transduction

SPECIFICITY

INTEGRITY

ECONOMY

X

Y

Z

Signal

Receptor

Protein -1

Protein -2

Protein -n

otein Network

Effectors(e.g.,enzymes,transcriptionfactors,etc)

Biological Responses

Messengers

Signaling Cascades

Amplification of the signal

1 ligand

1 receptor

n

1. 10 intracellular messengers

synaptic

Modalities of transmission

paracrine

endocrine

distance

diffusion

decay

Modalities of transmission

SPECIFICITY

Ligands and receptors