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Math Model Nat Phenom Vol No pp

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19 pages
Math. Model. Nat. Phenom. Vol. 2, No. 1, 2008, pp. 104-123 Diagnostics of the AML with immunophenotypical data A. Plesaa, G. Ciupercab V. Louvetb, L. Pujo-Menjouetb 1 S. Genieysb, C. Dumonteta X. Thomasa and V. Volpertb a Service d'Hematologie clinique, Hospices Civils de Lyon, 69003 Lyon, France b Universite de Lyon, Universite Lyon1, CNRS UMR 5208 Institut Camille Jordan F - 69200 Villeurbanne Cedex, France Abstract. Patients with acute myeloblastic leukemia (AML) are divided according to the French American British (FAB) classification into eight subgroups (M0 to M7) on the basis of their degree of maturation/differentiation. However, even if immunophenotypical characterization by flow cy- tometry is routinely used to distinguish between AML and acute lymphoblastic leukemia (ALL), it is not yet well established for the identification within the AML subgroups. Here we show that cer- tain subgroups of AML can be identified with a good accuracy (80% of the patients we analyzed) by means of the expression of specific markers. Key words: acute myeloblastic leukemia, diagnostic, FAB classification , cell markers, mathemat- ical modelling. AMS subject classification: 62-07, 62P10, 92B15, 92B05 1. Introduction We analyze here the immunophenotypical data obtained with flow cytometry in a group of 213 patients diagnosed with acute myeloblastic leukemia (AML).

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VMoal.th2.,MNoo.de1l,.2N0a0t8.,Pphpe.n1o0m4-.123DiagnosticsoftheAMLwithimmunophenotypicaldataA.Plesaa,G.CiupercabV.Louvetb,L.Pujo-Menjouetb1S.Ge´nieysb,C.DumontetaX.ThomasaandV.VolpertbaServicedHe´matologieclinique,HospicesCivilsdeLyon,69003Lyon,FrancebUniversite´deLyon,Universite´Lyon1,CNRSUMR5208InstitutCamilleJordanF-69200VilleurbanneCedex,FranceAbstract.Patientswithacutemyeloblasticleukemia(AML)aredividedaccordingtotheFrenchAmericanBritish(FAB)classificationintoeightsubgroups(M0toM7)onthebasisoftheirdegreeofmaturation/differentiation.However,evenifimmunophenotypicalcharacterizationbyflowcy-tometryisroutinelyusedtodistinguishbetweenAMLandacutelymphoblasticleukemia(ALL),itisnotyetwellestablishedfortheidentificationwithintheAMLsubgroups.Hereweshowthatcer-tainsubgroupsofAMLcanbeidentifiedwithagoodaccuracy(80%ofthepatientsweanalyzed)bymeansoftheexpressionofspecificmarkers.Keywords:acutemyeloblasticleukemia,diagnostic,FABclassification,cellmarkers,mathemat-icalmodelling.AMSsubjectclassification:62-07,62P10,92B15,92B051.IntroductionWeanalyzeheretheimmunophenotypicaldataobtainedwithflowcytometryinagroupof213patientsdiagnosedwithacutemyeloblasticleukemia(AML).Thediagnosisofthisdiseaseiscur-rentlyestablishedonthebasisofcytomorphologicalanalysisaccordinglytotheFrench-American-British(FAB)classification,andsupportedbyenzymaticmeasurements.Immunophenotyping1Correspondingauthor.E-mail:pujo@math.univ-lyon1.fr401