The Vitamine Manual

The Vitamine Manual

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The Project Gutenberg EBook of The Vitamine Manual, by Walter H. EddyCopyright laws are changing all over the world. Be sure to check the copyright laws for your country beforedownloading or redistributing this or any other Project Gutenberg eBook.This header should be the first thing seen when viewing this Project Gutenberg file. Please do not remove it. Do notchange or edit the header without written permission.Please read the "legal small print," and other information about the eBook and Project Gutenberg at the bottom ofthis file. Included is important information about your specific rights and restrictions in how the file may be used. Youcan also find out about how to make a donation to Project Gutenberg, and how to get involved.**Welcome To The World of Free Plain Vanilla Electronic Texts****eBooks Readable By Both Humans and By Computers, Since 1971*******These eBooks Were Prepared By Thousands of Volunteers!*****Title: The Vitamine ManualAuthor: Walter H. EddyRelease Date: April, 2005 [EBook #7983] [Yes, we are more than one year ahead of schedule] [This file was firstposted on June 8, 2003]Edition: 10Language: English*** START OF THE PROJECT GUTENBERG EBOOK THE VITAMINE MANUAL ***Produced by Juliet Sutherland, Richard Prairie, Charles Franks and the Online Distributed Proofreading Team.THE VITAMINE MANUALA Presentation of Essential DataAbout theNew Food FactorsBYWALTER H. EDDYASSOCIATE PROFESSOR PHYSIOLOGICAL CHEMISTRYTeachers College, ...

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The Project Gutenberg EBook of The VitamineManual, by Walter H. EddyCopyright laws are changing all over the world. Besure to check the copyright laws for your countrybefore downloading or redistributing this or anyother Project Gutenberg eBook.This header should be the first thing seen whenviewing this Project Gutenberg file. Please do notremove it. Do not change or edit the headerwithout written permission.Please read the "legal small print," and otherinformation about the eBook and ProjectGutenberg at the bottom of this file. Included isimportant information about your specific rights andrestrictions in how the file may be used. You canalso find out about how to make a donation toProject Gutenberg, and how to get involved.**Welcome To The World of Free Plain VanillaElectronic Texts****eBooks Readable By Both Humans and ByComputers, Since 1971*******These eBooks Were Prepared By Thousandsof Volunteers!*****Title: The Vitamine ManualAuthor: Walter H. EddyRelease Date: April, 2005 [EBook #7983] [Yes, weare more than one year ahead of schedule] [Thisfile was first posted on June 8, 2003]Edition: 10Language: English*** START OF THE PROJECT GUTENBERGEBOOK THE VITAMINE MANUAL ***Produced by Juliet Sutherland, Richard Prairie,Charles Franks and the Online DistributedProofreading Team.
THE VITAMINE MANUALA Presentation of Essential DataAbout theNew Food FactorsBYWALTER H. EDDYASSOCIATE PROFESSOR PHYSIOLOGICALCHEMISTRYTeachers College, Columbia UniversityCONTENTSCHAPTER IHOW VITAMINES WERE DISCOVEREDCHAPTER IITHE ATTEMPTS TO DETERMINE THECHEMICAL NATURE OF A VITAMINECHAPTER IIITHE METHODS USED IN TESTING FORVITAMINESCHAPTER IVTHE YEAST TEST FOR VITAMINE BCHAPTER VTHE SOURCES OF THE VITAMINESCHAPTER VITHE CHEMICAL AND PHYSIOLOGICALPROPERTIES OF THE VITAMINES
CHAPTER VIIHOW TO UTILIZE THE VITAMINES IN DIETSCHAPTER VIIIAVITAMINOSES OR THE DISEASES THATRESULT FROM VITAMINE DEFICIENCIESCHAPTER IXBIBLIOGRAPHYPREFACEThe presentation of essential data concerningvitamines to succeeding groups of students hasbecome increasingly difficult with the developmentof research in this field. The literature itself hasassumed a bulk that precludes sending the studentto original sources except in those instances whenthey are themselves to become investigators. Thedemand on the part of the layman for conciseinformation about the new food factors isincreasing and worthy of attention. For all of thesereasons it has seemed worth while to collate theexisting data and put it in a form which would beavailable for both student and layman. Such is thepurpose of this little book.It has been called a manual since the arrangementaims to provide the student with working materialand suggestions for investigation as well asinformation. The bibliography, the data in thechapter on vitamine testing, the tables and thesubdivision of subject matter have all beenarranged to aid the laboratory workers and it is thehope that this plan may make the manual ofespecial value to the student investigator. Themanagement also separates the details necessaryto laboratory investigation from the more purelyhistorical aspects of the subject which we believewill be appreciated by the lay reader as well as thestudent.No apologies are made for data which onpublication shall be found obsolete. The wholesubject is in too active a state of investigation topermit of more than a record of events and theirapparent bearing. Whenever there is controversythe aim has been to cite opposing views and
indicate their apparent value but with full realizationthat this value may be profoundly altered by newdata.Since the type of the present manual was set,Drummond of England has suggested that we dropthe terminal "e" in Vitamine, since the ending "ine"has a chemical significance which is to date notjustified as a termination for the name of theunidentified dietary factors. This suggestion hasbeen generally adopted by research workers andthe spelling now in use is Vitamin A, B, or C. It hashardly seemed worth while to derange the entireset up of the present text to make this correctionand we have retained the form in use at the timethe manuscript was first set up. The suggestion ofDrummond, however, is sound and willundoubtedly be generally adopted by the researchworkers in the subject.Attempt has been made to cover all the importantcontributions up to April, 1921. Opportunity haspermitted the inclusion of certain data of still laterdate and undoubtedly other important papers ofearlier date will have been overlooked.It is a pleasure to acknowledge the assistancereceived in the preparation of the manuscript fromDr. H. C. Sherman, Dr. Mary S. Rose and Dr.Victor La Mer. Their suggestions have been mostvaluable and greatly appreciated.WALTER H. EDDY.Department of Physiological Chemistry, TeachersCollege, Columbia University, New York City, April,1921CHAPTER IHOW VITAMINES WERE DISCOVEREDIn 1911 Casimir Funk coined the name Vitamine todescribe the substance which he believed curativeof an oriental disease known as beri-beri. Thisdisease is common in Japan, the Philippines andother lands where the diet consists mainly of rice,and while the disease itself was well known itscause and cure had baffled the medical men formany years. Today in magazines, newspapers andstreet car advertisements people are urged to usethis or that food or medicament on the plea of itsvitamine content. In less than ten years the study
of vitamines has increased to such an extent that itis difficult to find a chemical journal of any month ofissue that does not contain one or more articlesbearing on the subject. Such a rapid rise to publicnotice suggests an importance that justifiesinvestigation by the laity as well as the chemist andin the pages that follow has been outlined in simplelanguage the biography of this newest and lustiestof the chemist's children.Dr. Funk christened one individual but the familyhas grown since 1911 to three members which forlack of better names are now called vitamines "A,""B," and "C." There are now rumors of anotherarrival and none dare predict the limits of thefamily. Had these new substances been limited totheir relation to an obscure oriental disease theywould have of course commanded the medicalattention but it is doubtful whether the generalpublic would have found it worth while to concernthemselves. It is because on better acquaintancethey have compelled us to reform our ideas onnutrition of both adults and babies and pick out ourfoods from a new angle, that we accord them theattention they demand and deserve. Granting then,their claim upon our attention, let us review ourpresent knowledge and try to see with just what weare dealing. This will be more easily accomplishedif we consider the vitamines first from the historicalside and reserve our attention to details ofbehavior until later.A limited diet of polished rice and fish is a stapleamong the peoples of the Orient. When the UnitedStates Government took over the Philippine Islandsin 1898 it sent there a small group of scientists toestablish laboratories and become acquainted withthe peculiarities of the people and their troubles.One of the first matters that engaged theirattention was the condition of the prisons whichwere most unsanitary and whose inhabitants werepoorly fed and treated. Reforms were put intooperation at once and the sanitary measures soonchanged these prisons to places not quite soabhorrent to the eye. In trying to improve the dietsof the prisoners little change was made in theircomposition because of the native habits but thereformers saw to it that the rice fed should beclean and white. In spite of these measures thefirst year saw a remarkable increase in the diseaseof beri-beri, and the little group of laboratoryscientists had at once before them the problem ofchecking a development that bid fair to become anepidemic. In fact, the logical discoverers of whatwe now know as the antineuritic vitamine orvitamine "B" should have been this same group oflaboratory workers for it was largely due to their
work between the years 1900 and 1911 that theground was prepared for Funks harvest.'The relation of rice to this disease was more than asuspicion even in 1898. In 1897 a Dutch chemist,Eijkman, had succeeded in producing in fowls asimilar set of symptoms by feeding them withpolished rice alone. This set of symptoms he calledpolyneuritis and this term is now commonly used tosignify a beri-beri in experimental animals. Eijkmanfound that two or three weeks feeding sufficed toproduce these symptoms and it was he who firstshowed that the addition of the rice polishings tothe diet was sufficient to relieve the symptoms.Eijkman first thought that the cortical materialcontained something necessary to neutralize theeffects of a diet rich in starch. Later however, hechanged his view and in 1906 his position waspractically the view of today. In that same year(1906) F. Gowland Hopkins in England had cometo the conclusion that the growth of laboratoryanimals demanded something in foods that couldnot be accounted for among the ordinary nutrients.He gave to these hypothetical substances thename "accessory food factors." To Hopkins and toEijkman may therefore be justly attributed thecredit of calling the world's attention to theunknown substances which Funk was to christen alittle later with the name vitamines. Other workers,of course, knew of these experiments of Eijkmanand Hopkins and in 1907 two of them, Fraser andStanton, reported that by extracting rice polishingswith alcohol they had secured a product which ifadded to the diet of a sufferer from beri-beriseemed to produce curative effects. It is obviousthat logic would have decreed that some of theseworkers should be the ones to identify and namethe curative material. But history is not bound bythe rules of logic and it was so in this case.Another student had been attracted to the problemand was working at the time in Germany where healso became acquainted with Eijkman's results andbegan the investigation of rice polishings onexperimental lines. This student was Casimir Funkand a little later he carried his studies to Englandwhere he developed the results that made him thefirst to announce the discovery of the unknownfactor which he christened vitamine. Funk's studiescombined a careful chemical fractioning of theextracts of rice polishings with tests for theirantineuritic power upon polyneuritic birds, after themanner taught by Eijkman. By carrying out thisfractioning and testing he obtained from a largevolume of rice polishings a very small amount of acrystalline substance which proved to be curativeto a high degree. A little later he demonstrated thatthis same substance was particularly abundant in
brewers' yeast. From these two sources heobtained new extracts and carefully repeated hisanalytical fractionings. The result was thedemonstration that they contained a substancewhich could be reduced to crystalline form and wastherefore worthy of being considered a chemicalsubstance. In 1911, before Fraser and Stanton orany other workers had been able to show to whattheir curative extracts were due, Funk produced hisproduct, demonstrated its properties and claimedhis right to naming the same. At that he barelyescaped priority from still another source. Thechemists in Japan were naturally interested in thisproblem and possessed an able worker by thename of Suzuki. Suzuki and his co-workers Odakeand Shimamura were engaged in the samefractioning processes with polishings and entirelyindependently of Funk or other workers they toosucceeded in isolating a curative substance andpublished their discovery the same year as Funk,1911. Their methods were later shown to beidentical up to a certain point. Suzuki called hisproduct "Oryzanin." Funk's elementary analyseshad shown the presence of nitrogen in this productand his method of extraction indicated that thisnitrogen was present in basic form. For that reasonhe suggested that his product belonged to a classof substances which chemists call "amines." Sinceits absence meant death and its presence life whatmore natural than to call it the Life-amine or Vita-amine. This is the origin of Funk's nomenclature.Both Funk's original crystals and Suzuki's oryzaninwere later shown to be complexes of the curativesubstances combined with adulterants and we donot yet know just what a vitamine is or whether it isan amine at all but no one since 1911 has beenable to get any nearer to the identification thanFunk and while he has added much data to hisearlier studies he has himself not yet given us thepure vitamine. For that reason it has beensuggested by various people that the namevitamine should not be used since it has nosufficient evidence to support it. Hopkins ofEngland had suggested the name "accessory foodfactors." E. V. McCollum holds that we should callthem the "unidentified dietary factors" and addedlater to this phrase, the terms water-soluble "B"and fat-soluble "A" after the fat soluble form wasdiscovered. Most chemists feel, however, that thepurpose of nomenclature is brevity combined withready recognition of what you are discussing andthat it is unnecessary to change the name vitamineuntil we know exactly what the substances are.The result is that while still a mystery chemicallythey remain under the name of vitamine and thekinds are distinguished by the McCollum terms
"fat-soluble" A, "water-soluble" B, and "C."We see that beri-beri then was responsible forFunk's adding to our chemical entities a newmember but it does not yet appear why this entityconcerns our normal nutrition. To get this relationwe must turn for a moment to the state ofknowledge in 1911 in regard to foods and theirevaluation and what was going on in this field ofstudy at the time.A great advance in measuring food value was thediscovery of the isodynamic law. Translated intoordinary language this law states that when aperson eats a given amount of a given kind offood, that food may liberate in the body practicallythe same amount of energy that it would produce ifit were burned in oxygen outside of the body. Theconfirmation of this law permitted us to apply to themeasurement of food the same method we hadalready learned to use in measuring coal. Forconvenience the physicists devised a heatmeasure unit for this purpose and naturally called it.by a word that means heat, namely, "calorie"Using this unit and applying the isodynamic law itwas merely necessary to determine two things;first, how many calories a man produces in anygiven kind of work, second how many calories agiven weight of each kind of food will yield, andthen give the man as many calories of food as heneeds to meet his requirements when engaged in agiven kind of labor. The measurement andtabulation of food values in terms of calories andthe investigation of the calorie needs of men andwomen in various occupations has been one of thegreat contributions of the past twenty years ofnutritional study and to the progress made we oweour power to produce proper rations for every typeof worker. Army rations for example are built up offoods that will yield enough calories to supply theneeds of a soldier and during the recent warextended studies conducted in training camps allover the United States have shown that when thesoldier eats all he wants he will consume on theaverage about 3600 calories per day. In France theAmerican soldier's ration was big enough to yieldhim 4200 calories per day if he ate his entire dailyallowance.But calories are not the only necessities. A poundof pure fat will yield all the calories a soldier needsin a day but his language and morals wouldn'tstand the strain of such a diet. Neither would hishealth, for not only does his body demand fuel butalso that it be of a special kind. While there aremany kinds of foodstuffs, chemical analysis showsthat they are mainly combinations of pure
compounds of relatively few varieties. Thechemists call these proteins, fats, carbohydrates,and salts. Meats, eggs, the curd of milk, etc., arethe principal sources of protein. Sugars andstarches are grouped together under the name ofcarbohydrate. By salts is meant mineral matterssuch as common salt, iron and phosphoruscompounds, etc. In selecting foods it was foundthat the body required that the proportions of thesefour substances be kept within definite limits orthere was trouble. We know now that a man canget along nicely if he eats 50 grams of protein perday and makes up the rest of his calories incarbohydrates and fats, provided that to this isadded certain requirements in salts and water.It is also obvious that the foods given must bedigestible and palatable.We had reached this status some time before1911. But, a short time before this, there hadarisen a controversy as to the relative value ofdifferent types of proteins. The animal- vs.vegetable-protein controversy was one of the sideshows of this affair. This controversy had led to acareful study of the different kinds of proteins thatare found in foodstuffs. Through a brilliant series ofchemical investigations for whose description wehaven't time or space here, chemists had shownthat every protein was built up of a collection ofacids which were different in structure andproperties, that there were some seventeen ofthese in all and that any given protein might havepresent all seventeen or be lacking in one or moreand that the proportions present varied for everytype of protein. It was then obvious that proteinscould not be considered as identities. More thanthat, it was the necessary task of the food expertto separate all proteins into their acids or buildingstones and not only show what was present andhow much but determine the rôle each played inthe body. To this task many set their faces andhands.From the results there has accrued much progressin the evaluation of proteins but an unexpecteddevelopment was the part played by theseinvestigations in the story of the vitamines.About 1909-1910 Professors Osborne and Mendelunder a grant from the Carnegie Institution begana detailed investigation into the value of purifiedproteins from various sources. In their experimentsthey used the white rat as the experimental animaland proceeded to feed these animals a mixtureconsisting of a single purified protein supplementedwith the proper proportions of fat carbohydrate,