Control of attention before reflexive and intentional saccades [Elektronische Ressource] / vorgelegt von Susana Maria Casaña Pérez

Casana-Perez, Azquinezer Susana

Sujets

• Gesundheit

Informations

• Publié par: ludwig-maximilians-universitat_munchen
• Publié le: 01 janvier 2004
• Nombre de lectures: 32
• Langue: Deutsch

Extrait

Aus der Neurologischen Klinik und Poliklinik Großhadern
der Universität München
Vorstand: Prof. Dr. med. Dr. h. c. Thomas Brandt, FRCP
CONTROL OF ATTENTION BEFORE REFLEXIVE
AND INTENTIONAL SACCADES
Dissertation
zum Erwerb des Doktorgrades der Medizin
an der Medizinischen Fakultät der
Ludwig-Maximilians-Universität zu München
Vorgelegt von
Susana Maria Casaña Pérez
aus
Valencia
(Spanien)
Jahr
2004Mit Genehmigung der Medizinischen Fakultät
der Universität München
Berichterstatter: Prof. Dr. A. Straube
Mitberichterstatter: Prof. Dr. I. Rentschler
Prof. Dr. R. Haberl
Mitbetreuung durch den
promovierten Mitarbeiter: Dr.-Ing. T. Eggert
Dekan: Prof. Dr. med. Dr. h. c. K. Peter
Tag der mündlichen Prüfung: 21.10.2004Index
Index
Index........................................................................................................................................... 3
Acknowledgements .................................................................................................................... 5
Preface........................................................................................................................................ 6
1 Eye Movements.................................................................................................................. 7
2 Saccadic eye movements.................................................................................................... 8
2.1 Introduction ................................................................................................................ 8
2.2 Classification.............................................................................................................. 8
2.3 Saccade latency .......................................................................................................... 9
Gap and overlap stimuli ............................................................................................... 10
2.4 Control of saccadic eye movements......................................................................... 10
2.4.1 Peripheral oculomotor system.......................................................................... 10
2.4.2 Central oculomotor structures for saccades ..................................................... 12
3 Visual attention ................................................................................................................18
3.1 Covert and overt attention........................................................................................ 18
3.2 Brain areas involved on selective visual attention ................................................... 18
4 Relationship between visual attention and saccades ........................................................ 20
4.1 Independence hypothesis.......................................................................................... 20
4.2 Reciprocal Relation .................................................................................................. 21
4.3 Functional 22
4.4 Premotor theory of attention .................................................................................... 22
4.5 Visual Attention Model (VAM)............................................................................... 23
5 Questions.......................................................................................................................... 26
6 Experiment 1: Control Subjects ....................................................................................... 27
6.1 Methods.................................................................................................................... 27
6.2 Apparatus ................................................................................................................. 27
6.3 Experimental Procedures.......................................................................................... 28
6.3.1 Experiment 1.A: Intentional saccade task ........................................................ 29
6.3.2 Experiment 1.B: Intentional fixation task 30
6.3.3 Experiment 1.C: Reflexive saccadic task......................................................... 31
6.3.4 Experiment 1.D: Reflexive fixation task.......................................................... 31
6.4 Data analysis ............................................................................................................ 32
6.5 Results ......................................................................................................................34
6.5.1 Discrimination Performance ............................................................................ 34
6.5.2 Confidence ....................................................................................................... 36
6.5.3 Manual reaction times ...................................................................................... 37
6.5.4 Saccade latency ................................................................................................ 38
6.5.5 Saccade Performance ....................................................................................... 39
6.6 Discussion ................................................................................................................ 39
6.6.1 Discrimination Performance 39
6.6.2 Confidence 41
6.6.3 Manual reaction time........................................................................................ 41
6.6.4 Saccade latency 42
6.6.5 Saccade Performance 43
7 Experiment 2: Parkinson Disease (PD)............................................................................ 45
3Index
7.1 Introduction .............................................................................................................. 45
7.2 Methods.................................................................................................................... 46
7.3 Apparatus ................................................................................................................. 46
7.4 Experimental Procedures.......................................................................................... 47
7.5 Data analysis ............................................................................................................ 47
7.6 Results ......................................................................................................................49
7.6.1 Saccade Performance ....................................................................................... 49
7.6.2 Fixation Performance 50
7.6.3 Confidence ........................................................................................................... 51
7.6.4 Discrimination Performance ............................................................................ 52
7.7 Discussion ................................................................................................................ 54
7.7.1 Saccade Performance 54
7.7.2 Fixation Performance ....................................................................................... 55
7.7.3 Confidence ....................................................................................................... 55
7.7.4 Discrimination Performance 56
8 Experiment 3: Cerebellar Disorders................................................................................. 59
8.1 Introduction .............................................................................................................. 59
8.2 Methods.................................................................................................................... 60
8.3 Apparatus ................................................................................................................. 60
8.4 Experimental Procedures.......................................................................................... 61
8.5 Data analysis ............................................................................................................ 61
8.6 Results ......................................................................................................................62
8.6.1 Saccade performance........................................................................................ 62
8.6.2 Fixation performance ....................................................................................... 63
8.6.3 Confidence ....................................................................................................... 64
8.6.4 Discrimination performance............................................................................. 65
8.7 Discussion ................................................................................................................ 67
8.7.1 Saccadic Performance ...................................................................................... 67
8.7.2 Fixation Performance 68
8.7.3 Confidence 68
8.7.4 Discrimination Performance ............................................................................ 68
9 General Discussion........................................................................................................... 71
10 Summary ...................................................................................................................... 74
11 Zusammenfassung..............................