Diagnostic and experimental applications of cortico-muscular and intermuscular frequency analysis [Elektronische Ressource] / Pascal Grosse

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Informations

• Publié par: humboldt-universitat_zu_berlin
• Publié le: 01 janvier 2004
• Nombre de lectures: 24
• Langue: English
• Poids de l'ouvrage: 5 Mo

Extrait

Klinik und Poliklinik für Neurologie
HABILITATIONSSCHRIFT
Diagnostic and experimental applications
of cortico-muscular and intermuscular
frequency analysis
zur Erlangung der Lehrbefähigung im Fach Neurologie
Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum
Pascal Grosse
Prof. Dr. med. Paul Martin
Gutachter: 1. Prof. Dr. med. Benecke
2. Prof. Dr. med. Deuschl
eingereicht: September 2003
Datum der Habilitation: 17.5.2004
1Table of contents

Abbreviations.....................................................................................................................................6

1. Introduction ............................................................................................................................7
1.1. Physiological drives to muscle..............................................................................................8
1.2. Frequency analysis in pathological conditions ...................................................................11
1.2.1. Cortical myoclonus ..........................................................................................................12
1.2.2. Tremor..............................................................................................................................13
1.2.3. Parkinson’s disease..........................................................................................................14
1.2.4. Dystonia ...........................................................................................................................14
1.2.5. Stroke................................................................................................................................15
1.2.6. Functional neurosurgery..................................................................................................15

2. Methodology..........................................................................................................................16
2.1. Coherence...........................................................................................................................18
2.2. Phase...................................................................................................................................19
2.3. Cumulant density estimate.20
2.4. Surrogate measures of cortico-muscular coupling: EMG-EMG frequency analysis..........20
2.5. General problems of recording and interpretation..............................................................21
2.5.1. The signal and its collection ............................................................................................21
2.5.2. Coherence ........................................................................................................................23
2.5.3. Phase................................................................................................................................23

3. Frequency analysis in high frequency rhythmic myoclonus ............................................24
3.1. Patients and methods...........................................................................................................26
3.1.1. Patients and healthy subjects...........................................................................................26
3.1.2. EEG and EMG recording.................................................................................................27
3.1.3. Analysis ............................................................................................................................28
3.2. Results.................................................................................................................................29
23.2.1. Raw EMG .........................................................................................................................29
3.2.2. Frequency analysis ..........................................................................................................29
3.2.3. Back-averaging ................................................................................................................41
3.3. Discussion...........................................................................................................................43

4. EMG-EMG-frequency analysis in limb dystonia..............................................................49
4.1. Patients and methods...........................................................................................................50
4.1.1. Patients.............................................................................................................................50
4.1.2. Recordings........................................................................................................................53
4.1.3. Analysis............55
4.1.4. Statistics ...........................................................................................................................55
4.2. Results.................................................................................................................................56
4.1.2. Clinical appearance and raw EMG in the lower limb.....................................................56
4.2.2. Frequency analysis in the lower leg ................................................................................58
4.2.3. EMG-EMG Coherence in the upper extremity ................................................................61
4.3. Discussion...........................................................................................................................62

5. Coherence analysis in the myoclonus of corticobasal degeneration................................66
5.1. Patients and methods...........................................................................................................66
5.1.1. Patients.............................................................................................................................66
5.1.2. Recordings........................................................................................................................67
5.1.3. Frequency analysis and back-averaging .........................................................................68
5.1.4. Statistics ...........................................................................................................................68
5.2. Results.................................................................................................................................69
5.3. Discussion...........74

6. Bilaterally synchronous oscillatory EMG-EMG activity evoked by the acoustic startle
the healthy human...........................................................................................................................76
6.1. Methods...............................................................................................................................77
6.1.1. Subjects and recording procedure ...................................................................................77
6.1.2. Analysis ............................................................................................................................78
36.1.3. Statistics ...........................................................................................................................79
6.2. Results.................................................................................................................................80
6.3. Discussion...........................................................................................................................86

7. Summary and perspectives..................................................................................................89

References ........................................................................................................................................92
4Publications of work incorporated in this thesis


Grosse P, Cassidy M, Brown P. EEG-EMG, MEG-EMG and EMG-EMG Frequency
Analysis: Physiological Principles and Clinical Applications. Clinical Neurophysiology
2002;113:1523-1531.

Grosse P, Guerrini R, Parmiggiani L, Bonanni P, Pogosyan A, Brown P. Abnormal
corticomuscular and intermuscular coupling in high frequency rhythmic myoclonus. Brain
2003;126:326-342

Grosse P, Kühn A, Cordivari C, Brown P. Synchronising influences in the myoclonus of
corticobasal degeneration. Movement Disorders 2003;18:1345-1350.

Grosse P, Brown P. The acoustic startle evokes bilatarally synchronous oscillatory EMG
activity in the healthy human. Journal of Neurophysiology 2003;90:1654-1661.

Grosse P, Edwards M, Tijssen MAJ, Schrag A, Lees AJ, Bhatia KP, Brown P. Patterns of
EMG-EMG coherence in limb dystonia. Movement Disorders, in press
5Abbreviations

First dorsal interosses muscle 1DI
ANOVA Analysis of variance
APB Abductor pollicis brevis muscle
CBD Corticobasal degeneration
Carbamazepine CBZ
CLB Clobazam
CZP Clonazepam
DPH Phenytoin
EEG Electroencephalogram
Electromyogram EMG
ESM Ethosuximide
FE Finger extensor muscle
FF Finger flexor muscle
Fast Fourier transform FFT
GC Gastrocnemius muscle
GLM General linear model
LEV Levetiracetam
Multivariate autoregressive model MAR
MEG Magnetoenceph