Effect of Prior Bilateral Oophorectomy on the Presentation of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers

Metcalfe, Foulkes, Lynch, Ghadirian Parviz, Tung Nadine, Olivotto, Warner Ellen, Olopade Olufunmilayo, Eisen Andrea, Weber Barbara, Mclennan Jane, Sun Ping, Narod

Description

Purpose To compare the presentation of invasive breast cancer in BRCA1 and BRCA2 mutation carriers with and without prior bilateral oophorectomy. Patients and methods Women with a BRCA1 or BRCA2 mutation with the diagnosis of invasive breast cancer were identified from ten cancer genetics clinics. The medical history, medical treatment records and pathology reports for the breast cancers were reviewed. Information was abstracted from medical charts, including history (and date) of oophorectomy, date of breast cancer diagnosis, stage of disease, and pathologic characteristics of the breast cancer. Women with prior bilateral oophorectomy were matched by age, year of diagnosis, and mutation with one or more women who had two intact ovaries at the time of breast cancer diagnosis. Characteristics of the breast tumours were compared between the two groups. Results Women with prior bilateral oophorectomy presented with smaller tumours on average compared to women without prior oophorectomy (mean size 1.50 cm vs. 1.95 cm; p = 0.01). Additionally, although not statistically significant, women with intact ovaries were more likely to have high-grade tumour (70% vs. 54%: p = 0.10) and to have positive lymph nodes (34% vs. 18%; p = 0.11) compared to women with prior bilateral oophorectomy. Conclusions Bilateral oophorectomy prior to breast cancer appears to favourably influence the biological presentation of breast cancer in BRCA1 and BRCA2 mutation carriers.

Sujets

• BRCA1
• BRCA2
• Breast cancer
• Oophorectomy

Informations

• Publié par: biomed
• Publié le: 01 janvier 2005
• Nombre de lectures: 17
• Langue: English

Extrait

Hereditary Cancer in Clinical Practice 2005; 3(2) pp. 53-57

Effect of Prior Bilateral Oophorectomy on the Presentation of Breast Cancer in BRCA1 and BRCA2 Mutation Carriers

1, 23 45 67 8 Kelly A. Metcalfe, William D. Foulkes , Henry T. Lynch , Parviz Ghadirian , Nadine Tung , Ivo A. Olivotto , Ellen Warner , 9 810 112 2 Olufunmilayo Olopade , Andrea Eisen , Barbara Weber, Jane McLennan, Ping Sun , Steven A. Narod

1 2 Faculty of Nursing, University of Toronto, Canada;The Centre for Research in Women’s Health, Sunnybrook and Women’s College Health Sciences Centre, Toronto, 3 4 Canada; Programin Cancer Genetics, McGill University, Montreal, Canada;Department of Preventive Medicine and Public Health, Creighton University School of 5 6 Medicine, Omaha, USA;Epidemiology Research Unit, Research Centre of Centre Hospitalier de l’Université de Montréal, Montreal, Canada;Beth Israel Deaconess 7 8 Hospital, Boston Massachusetts, USA;BC Cancer Agency, Victoria, B.C., Canada;Sunnybrook and Women’s College Health Sciences Centre, Toronto, Canada; 9 1011 University of Chicago, USA;Department of Hematology/Oncology, University of Pennsylvania, Philadelphia, USA;University of California, San Francisco, USA

Key words: BRCA1, BRCA2, breast cancer, oophorectomy

Corresponding author: Dr. Steven A. Narod, Canada Research Chair in Breast Cancer, Centre for Research in Women’s Health, 790 Bay Street, 7th floor, Toronto, ON M5G 1N8 Canada. Phone [phone], fax [phone], e-mail: [e-mail]

Submitted: 7 April 2005 Accepted: 28 April 2005

Abstract Purpose: To compare the presentation of invasive breast cancer in BRCA1 and BRCA2 mutation carriers with and without prior bilateral oophorectomy. Patients and methods: Women with a BRCA1 or BRCA2 mutation with the diagnosis of invasive breast cancer were identified from ten cancer genetics clinics. The medical history, medical treatment records and pathology reports for the breast cancers were reviewed. Information was abstracted from medical charts, including history (and date) of oophorectomy, date of breast cancer diagnosis, stage of disease, and pathologic characteristics of the breast cancer. Women with prior bilateral oophorectomy were matched by age, year of diagnosis, and mutation with one or more women who had two intact ovaries at the time of breast cancer diagnosis. Characteristics of the breast tumours were compared between the two groups. Results: Women with prior bilateral oophorectomy presented with smaller tumours on average compared to women without prior oophorectomy (mean size 1.50 cm vs. 1.95 cm; p=0.01). Additionally, although not statistically significant, women with intact ovaries were more likely to have high-grade tumour (70% vs. 54%: p=0.10) and to have positive lymph nodes (34% vs. 18%; p=0.11) compared to women with prior bilateral oophorectomy. Conclusions: Bilateral oophorectomy prior to breast cancer appears to favourably influence the biological presentation of breast cancer in BRCA1 and BRCA2 mutation carriers.

Introduction

Women with a BRCA1 or BRCA2 mutation have up to an 87% lifetime risk of developing invasive breast cancer [1]. The surgical removal of the ovaries in women with a BRCA1 or BRCA2 mutation has been shown to reduce the risk of developing breast cancer

[2]. Nevertheless, some women who have had bilateral oophorectomy go on to develop breast cancer. Previous research has suggested that there may be an association between menopausal status and prognostic features of breast cancer [3], but this association has not been studied in women with a BRCA1 or BRCA2 mutation.