Genetic dissection of organellar-translation-dependent retrograde signalling in Arabidopsis [Elektronische Ressource] / vorgelegt von Elena Fenino

Genetic Dissection of Organellar-Translation-Dependent Retrograde Signalling in Arabidopsis Dissertation zur Erlangung des Doktorgrades der Fakultät für Biologie der Ludwig-Maximilians-Universität München Vorgelegt von Elena Fenino aus Mailand, Italien München, June 2010 Erstgutachter: Prof. Dr. Dario Leister Zweitgutachter: Prof. Dr. Jörg Nickelsen Tag der mündlichen Prüfung: 10 June 2010 “Do you know the difference between an error and a mistake? […] Anyone can make an error. But that error does not become a mistake until you refuse to correct it” (Timothy Zahn) Summary/Zusammenfassung Summary Retrograde mechanisms have evolved to communicate the functional and developmental state of the organelles to the nucleus, which in turn modulates anterograde control and cellular metabolism accordingly. Previous works showed that simultaneous impairment in the organelle translational machinery, due to a mutation in the prolyl-tRNA synthetase PRORS1, targeted to both chloroplasts and mitochondria, induces a specific downregulation of nuclear photosynthetic genes.