Homology modeling of toll-like receptor ligand-binding domains [Elektronische Ressource] : a leucine-rich repeat assembly approach / vorgelegt von Tiandi Wei

Tiandi Wei

Description

Homology Modeling of Toll-Like Receptor Ligand-Binding Domains: A Leucine-Rich Repeat Assembly Approach Dissertation Fakultät für Geowissenschaften Ludwig-Maximilians-Universität München vorgelegt von Tiandi Wei München, den 24. Februar 2010 Erstgutachter: Prof. Dr. Wolfgang M. Heckl Zweitgut. Robert W. Stark Prüfungstermin: 26.05.2010 Abstract Abstract Toll-like receptors (TLRs) are in the front-line during the initiation of an innate immune response against invading pathogens. TLRs are type I transmembrane proteins that are expressed on the surface of immune system cells. They are evolutionarily conserved between insects and vertebrates. To date, 13 groups of mammalian TLRs have been identified, ten in humans and 13 in mice. They share a modular structure that consists of a leucine-rich repeat (LRR) ectodomain, a single transmembrane helix and a cytoplasmic Toll/interleukin-1 receptor (TIR) domain. Most TLRs have been shown to recognize pathogen-associated molecular patterns (PAMPs) from a wide range of invading agents and initiate intracellular signal transduction pathways to trigger expression of genes, the products of which can control innate immune responses. The TLR signaling pathways, however, must be under tight negative regulation to maintain immune balance because over-activation of immune responses in the body can cause autoimmune diseases.

Informations

• Publié par: ludwig-maximilians-universitat_munchen
• Publié le: 01 janvier 2010
• Nombre de lectures: 6
• Langue: English
• Poids de l'ouvrage: 9 Mo

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