Hormonal regulation of ATP binding cassette transporters [Elektronische Ressource] / vorgelegt von Mohammed Ahmed A. Taher

Mohamed And Waffa

Sujets

• Gesundheit

Informations

• Publié par: universitat_regensburg
• Publié le: 01 janvier 2004
• Nombre de lectures: 20
• Langue: English
• Poids de l'ouvrage: 1 Mo

Extrait

Hormonal Regulation of
ATP Binding Cassette Transporters








Dissertation zur Erlangung des Doktorgrades
der Naturwissenschaften (Dr.rer.nat.)
der Fakultät für Biologie und Vorklinische Medizin
der Universität Regensburg











vorgelegt von
Mohammed Ahmed A. Taher
Regensburg, im April 2004






































Promotionsgesuch eingereicht am:
Die Arbeit wurde angeleitet von: Prof. Dr. med. Gerd Schmitz
Prüfungsausschuß: Prof. Dr. Rosemarie Baumann
Prof. Dr. med. Gerd Schmitz
Prof. Dr. Eggehard Holler Stephan Schneuwly



Acknowledgements

In the name of ALLAH, the benificial, the merciful and most gracious. Before and
after any thing, I am very grateful to ALLAH who gave me the effort and patience to produce
this thesis.
This thesis was performed from August 2000 until February 2004 under the observation of
Prof. Dr. med. Gerd Schmitz, Dr. Thomas Langmann and Prof. Dr. Eggehard Holler in the
Institute of Clinical Chemistry at the University of Regensburg.
I am very grateful to Prof. Dr. med. Gerd Schmitz for his support in my work and for giving
beneficial and essential advices and discussions.
My sincere thanks are to Prof. Dr. Eggehard Holler who offered help in reviewing this thesis.
I gratefully acknowledge the support of Dr. Thomas Langmann. He was my teacher in
molecular biology and largely contributed to the completion of this thesis.
I want to express my thanks to all my colleagues especially to Dr. med. Wolfgang Drobnik,
Dr. Alfred Böttcher, Dr. med. Ashraf Dada, and Dr. Gerhard Liebisch for their support and
advices and also Manfred Haas, Wolfgang Hauer and Jolante Aiwanger for technical
assistance.






Abbreviations

18srRNA 18S-ribosomal RNA
a Adenin
aa Amino acid/s
ABC ATP binding cassette
ACAT Acyl-coenzyme A cholesterol acyltransferase
ACTH Adrenocorticotrophic hormone
AD Alzheimer disease
AP-1 Activating protein-1
Apo Apolipoprotein
ATP Adenosine triphosphate
AZ Alzheimer disease
BAT Brown adipose tissue
bp Base pair
BSA Bovine serum albumin
c Cytosine
cAMP Cyclic 3',5'-adenosine monophosphate
cDNA Complementary Deoxyribonucleic acid
CETP Cholesterol ester transfer protein
CFTR Cystic fibrosis transmembrane conductance regulators
CHD Coronary heart disease
Ci Curie
CMOAT Canalicular multispecific organic anion transport
CSF Colony stimulating factor
CT threshold cycle
CYP27 Cytochrome P27
DNA Deoxyribonucleic acid
DBN DNA binding domain
DHEA/S Dehydroepiandrosterone /sulfate ester (DHEAS)
DM Diabetes mellitus
DMEM Dulbecco´s modified Eagle´s medium
DR-4 Direct repeat sequences seperated by 4 nucleotides
EDTA Ethylendiamin –Tetraacetat
EIF2 Eucaryotic initiation factor 2
E-LDL Enzymatic modified LDL
ER Estrogen receptor
ERK Extracellular regulated kinase
FHD Familial HDL deficiency
FAS Fatty acid snthetase
Fra2 Fos related antigen 2
g Guanin
GnRH Gonadotrophin- releasing hormone
GR Glucocorticoid receptor

GS-H Reduced glutathione
h hour
HBD Hormone binding domain
HDL High density lipoprotein
HepG2 Human hepatoblastoma derived cell line
HL Hepatic lipase
HMG-CoA Hydroxymethylglutaryl coenzyme A
HRT Hormone replacement therapy
Hsp Heat shock proteins
ICAM Intracellular adhesion molecule
IGF Insulin-like growth factor
IL Interleukin
INF-γ Interferon-γ
IRS Insulin receptor substrate
KAP 1 Kruppel-associated protein 1
kDA Kilodalton
KIR Potassium inward rectifiers
LDL Low density lipoprotein
LH Luteinizing hormone or lutrophin
LPS lipopolysaccharide
LXR Liver X receptor
Mac. Macrophages
MAP Mitogen activated protein
M-CSF Macrophage CSF
MDR Multidrug resistance
MEK MAP extracellular related kinase
MHC Major Histocompatability Complex
NBD Nucleotide binding domain
NPY Nucleus neuropeptide Y
+NTCP Na /taurocholate cotransporting peptide
OABP Oligoadenyl binding protein
OB Leptin (the product of OB gene)
OB-R OB receptor
OCT 1 Organic cation transporter 1
PAF Platelet activating factor
PBS Phosphate buffer saline
PCR Polymerase chain reaction
PFIC Progressive Familial Intrahepatic Cholestasis
PI(3)K Phosphatidyl inositol 3-kinase
PPAR Peroxisome proliferator-activated receptor
Raf MAP kinase kinase
Rho-GTP Rho-guanosine triphosphatases
RLP Reminant like lipoprotein
RNA Ribonucleic acid

RNase Ribonuclease
rpm Rotate per minutes
RT Room temperature
RT-PCR Reverse transcription-PCR
RXR Retinoid X receptor
SCAN SRE-ZBP, CT-fin-51, AW-1 and Number 18 cDNA
SDP1 Scan domain containing protein 1
SDS Sodium dodecyl sulfate
Ser Serine
SMC Smooth muscle cells
SR-B1 Scavenger receptor class B1
SREBP1c Sterol Regulatory Element Binding Protein 1c
SRIF Somatotropin releasing inhibiting factor (somatostatin)
SS Somatostatin
t Thymin
T3 Triiodothyronine
T4 Tetraiodothyronine
TAP Tissue antigen presentation
Taq Thermophilus aquaticus
TBS-T Tris- buffer- saline with 0.1% tween
TD Tangier disease
TMD Transmembrane domain
TNF-α