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Publié par | ludwig-maximilians-universitat_munchen |
Publié le | 01 janvier 2008 |
Nombre de lectures | 28 |
Langue | Deutsch |
Poids de l'ouvrage | 4 Mo |
Extrait
In vivo imaging of the degenerating
and regenerating nervous system
Dissertation
zur Erlangung des Grades eines Doktors
der Naturwissenschaften
der Fakultät für Biologie
der Ludwig-Maximilians-Universität München
vorgelegt
von
Ali Ertürk
München, Jan 2008
iErklärung und ehrenwörtliche Versicherung:
Ich versichere, dass ich die vorliegende Arbeit selbstständig durchgeführt habe und
keine anderen als die aufgeführten Hilfsmittel und Quellen benutzt habe. Hiermit
erkläre ich, dass ich mich einer Doktorprüfung anderweitig ohne Erfolg nicht unterzogen
habe.
Ali Ertürk
München, January 9, 2008
ii DISSERTATION
submitted to the
Biology Faculty of Ludwig‐Maximilians University of Munich,
Germany
for the degree of
Doctor of Natural Sciences
Presented by
Ali Ertürk
Born in Sakarya, Turkey
iiiDeclaration
I declare that this thesis is my own original work was carried out between October 2003
and October 2007 under the supervision of Dr. Frank Bradke at the Max‐Planck‐Institute
of Neurobiology in Martinsried. It is submitted as PhD to the Biology Faculty of Ludwig‐
Maximilians University in Munich. No part of this research has been submitted in the
past, or is being submitted, for a degree or examination at any other University.
Ali Ertürk
München, January 9, 2008
ivFirst Referee : Prof. Dr. Rüdiger Klein
Second Referee : PD Dr. Angelika Böttger
thThe exam date : 26 February, 2008
The following article has been published based on my thesis:
Erturk A, Hellal F, Enes J, Bradke F (2007) Disorganized microtubules underlie the
formation of retraction bulbs and the failure of axonal regeneration. J Neurosci 27:9169-
9180.
vAcknowledgments
It would have been impossible to carry out this project without the help of several
people to whom I am very grateful. I would like to express my sincere gratitude to:
Dr. Frank Bradke for giving me the opportunity of working in his marvelous group at
Max‐Planck‐Institute of Neurobiology. Besides being a great supervisor and supporting
me during each step of my PhD work, his friendly and candid behaviors created a warm
atmosphere which I enjoyed very much. I am also grateful to him for letting me to do
my own ideas as well…
the members of my PhD thesis committee, PD Dr. Mark Hübener, Prof. Dr. Ferdinando
Rossi and Prof. Dr. med. Nikolaus Plesnila for extremely helpful and encouraging
discussions and advices…
Prof. Dr. Rüdiger Klein for being my doctor‐father and his supports for my fellowship…
Marianne Braun, Dietmute Büringer, James P. Chalcroft, Robert Schorner and EDV
group for technical support…
Tara Keck, Fabien Nadrigny, PD Dr. Frank Kirchhoff, Christoph Mauch and Prof. Hans
Ulrich‐Dodt for opening their facilities to collaborate…
all Bradke group members, Liane Meyn, Farida Hellal, Joana Enes, Bhavna Ylera, Sabina
Tahirovic, Boyan Garvalov, Harald Witte, Susana Gomis‐Rüth, Dorothee Neukirchen,
Michael Stiess for creating wonderful working atmosphere and elegant friendships with
the all funny lunches, coffee breaks and movie clubs…
Dr. Gaia Tavosanis and her group for useful discussions in the lab meetings…
all close friends especially to Oguzhan, Erkan, Öner, Fatih, Hüseyin and Cihan for their
spiritual supports…
my family, for all their generous supports to my life and to Melisa the cutie of the
family...
EU for feeding me through the NSR‐RTN Marie Curie fellowship…
all my NSR colleagues and supervisors in the network for the gorgeous friendship and
incredibly educative workshops…
vi
In vivo imaging of the degenerating
and regenerating nervous system
Dissertation
zur Erlangung des Grades eines Doktors
der Naturwissenschaften
der Fakultät für Biologie
der Ludwig-Maximilians-Universität München
vorgelegt
von
Ali Ertürk
München, Jan 2008
iErklärung und ehrenwörtliche Versicherung:
Ich versichere, dass ich die vorliegende Arbeit selbstständig durchgeführt habe und
keine anderen als die aufgeführten Hilfsmittel und Quellen benutzt habe. Hiermit
erkläre ich, dass ich mich einer Doktorprüfung anderweitig ohne Erfolg nicht unterzogen
habe.
Ali Ertürk
München, January 9, 2008