Infected biomaterials [Elektronische Ressource] : new strategies for local anti-infected treatment / Florian Matl

Florian Matl

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• Gesundheit

Informations

• Publié par: ludwig-maximilians-universitat_munchen
• Publié le: 01 janvier 2009
• Nombre de lectures: 58
• Langue: Deutsch
• Poids de l'ouvrage: 8 Mo

Extrait

Dissertation
zur Erlangung des Doktorgrades der Fakultät für
Chemie und Pharmazie der Ludwig-Maximilians-Universität
München



Infected Biomaterials
New Strategies For Local Anti-Infective Treatment







Florian Matl
aus München
2008
Bibliografische Information der Deutschen Nationalbibliothek
Die Deutsche Nationalbibliothek verzeichnet diese Publikation in der Deutschen
Nationalbibliografie; detaillierte bibliografische Daten sind im Internet über
http://dnb.ddb.de abrufbar.
1. Aufl. Göttingen : Cuvillier, 2009
Zugl.: München, Univ., Diss., 2008
978-3-86727-871-3

Erklärung
Diese Dissertation wurde im Sinne von § 13 Abs. 4 der Promotionsordnung vom 29. Januar
1998 von Herrn Prof. Dr. Dr. Axel Stemberger vom Institut für Experimentelle Onkologie
betreut und von Herrn Prof. Dr. Wolfgang Frieß von der Fakultät für Chemie und Pharmazie
vertreten.

Ehrenwörtliche Versicherung
Diese Dissertation wurde selbständig, ohne unerlaubte Hilfe erarbeitet.


München, am 25.07.08



Dissertation eingereicht am 25.07.08
1. Gutachter: Prof. Dr. Dr. A. Stemberger

2. Gutachter: Prof. Dr. W. Frieß
Mündliche Prüfung am: 29.09.08

 CUVILLIER VERLAG, Göttingen 2009
Nonnenstieg 8, 37075 Göttingen
Telefon: [phone]
Telefax: 0551-54724-21
www.cuvillier.de

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des Verlages ist es nicht gestattet, das Buch oder Teile
daraus auf fotomechanischem Weg (Fotokopie, Mikrokopie)
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1. Auflage, 2009
Gedruckt auf säurefreiem Papier

978-3-86727-871-3Acknowledgements


The presented thesis was written at the Institute of Medical Engineering at the Technical
University of Munich and at the Department of Pharmacy, Pharmaceutical Technology and
Biopharmaceutics at the Ludwig-Maximilians-University in Munich under supervision of
Prof. Dr. Dr. Axel Stemberger and Prof. Dr. Wolfgang Friess.

First of all I want to express my gratefulness to Prof. Dr. Dr. Axel W. Stemberger for the
possibility to be part of his research group and especially for his scientific guidance,
professional input and fruitful discussions throughout my work. I very much appreciate that
he offered me the opportunity to stay in Texas for a scientific project for three months and to
take part in many conferences throughout Europe. Thank you for the fantastic working
climate that made it a pleasure to be part of your group.

My special thanks go to Prof. Dr. Wolfgang Friess, who guided me through the
pharmaceutical part of my work with great engagement and supported me whenever questions
came up. Thank you for giving me the possibility to be part of your group and to write my
thesis at the Pharmaceutical Department at the Ludwig-Maximilians University Munich. It
has been a pleasure to work with you.

I want to thank Prof. Dr. Gross from the University of North Texas, USA for the outstanding
time in Denton, the tremendous support he gave me personally as well as professionally. It
was a great time for me – thank you very much.

Many thanks to Prof. Dr. Gerhard Winter for his enthusiastic and dedicated leadership of the
chair of Pharmaceutical Technology and Biopharmaceutics.

Special thanks go to my colleague Dipl.-Ing. Andreas Obermeier who shared most of the time
here at the IMETUM with me. Without his active support in setting up the experimental
constructions as well as organizing and planning things, this work would not have been
possible. Thanks for our fruitful and personal discussions and the fantastic working climate.

Many thanks to Katharina Seiffe, Julia Zlotnyk, Simone Repmann and Teissa Köhler who did
a great job during their student time in our working group. It was a pleasure to work with you. Special thanks to Tobias Pirzer for his parents and great support in all questions concerning
computer programs used for this thesis.

Thanks to Tiffany Kinney for reviewing parts of my thesis and Jochen Mayer for his
cooperation in the neuroscience project.

Thanks to Prof. Dr. Frank Böckler, Dr. Olga Mykhaylyk and Chemicell in Berlin for their
advice and contributions to the magnetic drug targeting project.

The microbiological investigations would not have been possible without the tremendous help
of Ms V. Vatou, Institute for Medical Microbiology at the Klinikum rechts der Isar, Technical
University, Munich – many thanks to you.

Many thanks go to Dipl. Phys. W. Kraus and Dipl.-Ing. H. Stephan for their engagement, and
the entire staff of the Neue Magnetodyn GmbH for their professional support and for
providing the equipment.

Special thanks to the entire staff of the Pharmaceutical Technology and Biopharmaceutics as
well as my colleagues at the IMETUM especially Susanne Schnell-Witteczek and Ursula
Hopfner for their professional support and the others for all the enjoyable dinners and night
sessions we had. We had a wonderful time together.

Furthermore I would like to thank the ITEM GmbH for the providing of laboratory space for
carrying out the series of bacteriological experiments and, in particular, Mr J. Hintermeier for
his very kind support.

My aunt Dr. Ingrid Hofmann and my uncle Dr. Hans Hofmann for their support at the
beginning of this thesis. Thank you very much.

My parents, my sister Saskia and my brother Mark and Corinna, I want to thank you all for
the support and the encouragement you gave me in all the years.


























For mom and dad







List of Abbreviations

a.c. Alternating current
AHL Acylated Homoserine Lactone
® ATCC American Type Culture Collection
cfu Colony-forming units
CP Chlorhexidine dipalmitate
CL dilaurate
d.c. Direct current
DG Diglyceride
EF Electric field
EMF Electro-magnetic field
EMF+ ind. EF Electro-magnetic field with additional a.c. electrical field
ePTFE Expanded PTFE
ICR Ion-Cyclotron-Resonance
MIC Minimal inhibitory concentration
MRSA Methicillin-resistant Staphylococcus aureus
OH Octenidine hydrochloride
PDLLA Poly(D,L)lactide
PET Polyethyleneterephtalate
PTFE Polytetrafluoroethylene
RIP RNA III Inhibiting Peptide
TA Tocopherole acetate
TG Triglyceride
TRAP Target of RNA III-Activating Peptide
USPIO Ultra-small superparamagnetic iron oxide