Long-term relation between anthropometric and metabolic changes in women with a risk of the metabolic syndrome ; Moterų antropometrinių ir medžiagų apykaitos rodiklių pokyčių ilgalaikis ryšys su metabolinio sindromo rizika

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Vilnius University Jelena Volochovič LONG-TERM RELATION BETWEEN ANTHROPOMETRIC AND METABOLIC CHANGES IN WOMEN WITH A RISK OF THE METABOLIC SYNDROME Summary of Doctoral Dissertation Medical Sciences, Medicine (07B) Vilnius, 2010 Doctoral dissertation was prepared at the Faculty of Medicine of Vilnius University in 2006 – 2010. Scientific tutors: Prof Dr Janina Didžiapetrienė (Institute of Oncology of Vilnius University, Biomedical Sciences, Medicine – 07 B) 2006-2007; Prof Dr Gražina Drąsutienė (Clinic of Obstetrics-Gynaecology of the Faculty of Medicine of Vilnius University, Biomedical Sciences, Medicine – 07 B) 2007-2010 . Consultant: Prof Dr Janina Tutkuvienė, Department of Anatomy, Histology and Anthropology of the Faculty of Medicine of Vilnius University, Biomedical Sciences, Medicine – 07 B.

Sujets

• Medicine
• Metabolic syndrome

Informations

• Publié par: vilnius_university
• Publié le: 01 janvier 2010
• Nombre de lectures: 17
• Langue: English

Extrait

 

   

                       

Vilnius University        

    Jelena Volochovič        LONG-TERM RELATION BETWEEN ANTHROPOMETRIC AND METABOLIC CHANGES IN WOMEN WITH A RISK OF THE METABOLIC SYNDROME

Summary of Doctoral Dissertation Medical Sciences, Medicine (07B)

Vilnius, 2010

Doctoral dissertation was prepared at the Faculty of Medicine of Vilnius University in 2006 –

2010.

Scientific tutors:

Prof DrJanina Didžiapetrien(Institute of Oncology of Vilnius University, Biomedical

Sciences, Medicine – 07 B) 2006-2007;

Prof Dr GražinaDrąsutien(Clinic of Obstetrics-Gynaecology of the Faculty of Medicine of

Vilnius University, Biomedical Sciences, Medicine – 07 B) 2007-2010 .

Consultant:

Prof DrJanina Tutkuvien, Department of Anatomy, Histology and Anthropology of the

Faculty of Medicine of Vilnius University, Biomedical Sciences, Medicine – 07 B.

The dissertation is defended at the Board of the Medical Science Trend of Vilnius University:

Chairman:

Prof Habil DrAleksandras Laucevičius University, Biomedical Sciences, Medicine (Vilnius

(07B) 

Members:

Prof Habil Dr Vytautas Usonis (Vilnius University, Biomedical Sciences, Medicine (07B) 

Prof Habil DrVaidutis Kučinskas(Vilnius University, Biomedical Sciences, Biology (01B)

Assoc Prof DrDaiva Vaitkien(Lithuanian University of Health Sciences, Biomedical Sciences,

Medicine (07B)

Assoc Prof Dr Mykolas Mauricas (National Institute of Scientific Researches Centre of

Innovative Medicine, Biomedical Sciences, Biology (01B)

Oponents:

Prof DrŽaneta Petrulionien(Vilnius University, Biomedical Sciences, Medicine (07B)

Prof Dr Dainius H. Pauža (Lithuanian University of Health Sciences, Biomedical Sciences, 

Biology (01B)

The dissertation will be defended at the meeting of the Board of the Medical Science Trend of Vilnius University on the 21 st  of14:00, at the Clinic of Obstetrics and December 2010,

Gynaecology of Vilnius University, Antakalnio str. 57, Vilnius.

 

The summary of the dissertation was sent off on the ________ of November 2010.

The of the doctoral dissertation is available for review at Vilnius university library (Universiteto

str. 3, LT-01122, Vilnius, Lithuania)

 

 

 

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Vilniaus universitetas        

    Jelena Volochovič        MOTER ANTROPOMETRINI IR MEDŽIAG APYKAITOS RODIKLI POKYČI ILGALAIKIS RYŠYS SU METABOLINIO SINDROMO RIZIKA 

Daktaro disertacijos santrauka Medicinos mokslai, medicina (07B)

Vilnius, 2010

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Disertacija rengta Vilniaus universiteto Medicinos fakultete 2006 – 2010 metais

 

Moksliniai vadovai:

Prof. dr. Janina Didžiapetrien (Vilniaus universiteto Onkologijos institutas, biomedicinos

mokslai, medicina – 07B) 2006 – 2007 m. m.:

Prof. dr. Gražina Drąsutien (Vilniaus universitetas, biomedicinos mokslai, medicina –07B)

2007 – 2010 m. m.

Konsultantas:

Prof. dr. Janina Tutkuvien (Vilniaus universitetas, biomedicinos mokslai, medicina–07 B)

  Disertacija ginama Vilniaus universiteto Medicinos mokslo krypties taryboje:

Pirmininkas:

Prof. habil. dr. Aleksandras Laucevičius (Vilniaus universitetas,

medicina– 07B).

Nariai:

biomedicinos mokslai,

Prof. habil. dr. Vytautas Usonis (Vilniaus universitetas, biomedicinos mokslai, medicina – 07B);

Prof. habil. dr. Vaidutis Kučinskas (Vilniaus universitetas, biomedicinos mokslai, biologija –

01B);

Doc. dr. Daiva Vaitkien (Lietuvos sveikatos moksluniversitetas, biomedicinos mokslai,

medicina– 07B);

Doc. dr. Mykolas Mauricas (Valstybinio mokslinio tyrim instituto Inovatyvios medicinos

centras, biomedicinos mokslai, biologija – 01B)

Oponentai:

Prof. dr. Žaneta Petrulionien (Vilniaus universitetas, biomedicinos mokslai, medicina– 07B);

Prof. dr. Dainius Haroldas Pauža (Lietuvos sveikatos moksltesistanuvire, biomedicinos

mokslai, biologija – 01B).

Disertacija bus ginama viešame Vilniaus universiteto Medicinos krypties tarybos posdyje 2010 m. gruodžio mn. 21 d. 14. 00 val., Vilniaus universiteto Akušerijos ir ginekologijos klinikos

Didžiojoje auditorijoje, Antakalnio g. 57, Vilnius

 

Disertacijos santrauka išsiuntinta 2010 m. lapkričio _________ d.  Disertacija galima peržirti Vilniaus universiteto bibliotekoje.        

 

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CONTENT

MOSTLY USED CONCEPTS AND ABBREVIATIONS............................................ 8

1. INTRODUCTION.................................................................................................... 10

1.1. Problem................................................................................................................ 10

1.2. Relevance and scientific newness of work.......................................................... 11

1.3. Theoretic and applicable meaning of work.......................................................... 11

2. AIM OF WORK....................................................................................................... 12

3. TASKS OF WORK.................................................................................................. 12

4. DEFENDED PROPOSITIONS ……………………………………………..…… 12

 

5. REVIEW OF LITERATURE................................................................................. 13

6. 

 

5.1. meaning for the function and pathology ofAdipose tissue –its topography and

the woman’s reproductive system....................................................................... 13

5.2. Adiposopathy....................................................................................................... 14

5.3. Adipokines........................................................................................................... 14

5.4.  17 …..Changes in the women’s body composition ……………………………….

5.4.1. Changes in the anthropometric parameters in women during

pregnancy..................................................................................................... 17

5.4.2. Changes in the anthropometric parameters in women during

perimenopause .............................................................................................. 18

5.5. Metabolic changes in women in different periods of life.................................... 19

5.5.1. Metabolic peculiarities in pregnant women............................................... 19

5.5.2. Metabolic peculiarities during perimenopause …..................................... 20

5.6. Metabolic syndrome ........................................................................................... 21

RESEARCH MATERIAL AND METHODS........................................................ 23

6.1. Research material................................................................................................. 23

6.2. Research methods................................................................................................ 23

6.2.1. Questionnaire survey................................................................................. 23

6.2.2. Anthropometric parameters ...................................................................... 23

6.2.3. Metabolic parameters................................................................................ 25

6.2.3.1. 

6.2.3.2. 

6.2.3.3. 

Lipid metabolism parameters.................................................. 26

Carbohydrate metabolism parameters...................................... 26

Adipokines metabolism parameters ........................................ 27

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6.2.4. Clinical researches..................................................................................... 27

6.2.5. Criteria of diagnostics of metabolic syndrome.......................................... 28

6.2.6. Methods of statistical analysis................................................................... 28

6.3. Ethical aspects..................................................................................................... 28

7. RESULTS.................................................................................................................. 29

8. 

 

7.1. Characteristic of the researched........................................................................... 29

7.2. Long-term changes in the women’s body............................................................ 31

7.2.1. Changes in anthropometric parameters of researched women within twenty

years.............................................................................................................. 31

7.2.2. Changes in metabolism of researched women within twenty years.......... 36

7.2.2.1. 

7.2.2.2. 

Changes in lipid metabolic parameters within twenty years ...36

Changes in glucose metabolism parameters within twenty

years....................................................................................................... 37

7.2.2.3. 

Relation between changes in anthropometric and metabolic

parameters in women and tendency to have metabolic syndrome ....... 38

7.3. Peculiarities of anthropometric and metabolic changes in healthy and metabolic

syndrome women during pregnancy and within twenty years............................ 38

7.3.1. Peculiarities of anthropometric changes in healthy and metabolic syndrome

women during pregnancy and within twenty years....................................... 39

7.3.2. changes in healthy and metabolic syndromePeculiarities of metabolism

women during pregnancy and within twenty years....................................... 47

7.3.2.1. 

Peculiarities of lipid changes in healthy and metabolic

syndrome women during pregnancy and within twenty years.............. 47

7.3.2.2. 

Peculiarities of glucose changes in healthy and metabolic

syndrome women during pregnancy and within twenty years.............. 50

7.4. Peculiarities of leptin and adiponectin metabolism in women under physiological

and pathological conditions................................................................................. 50

RESULT DISCUSSION ………………………………………………………….. 55

 

8.1. Long-term changes in the women’s body............................................................ 55

8.1.1. Changes in anthropometric parameters in researched women within twenty

years.............................................................................................................. 55

8.1.2. Metabolic changes in researched women within twenty years.................. 58

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9. 

8.2. Peculiarities of anthropometric and metabolic changes in healthy and metabolic

syndrome women during pregnancy and within twenty years............................ 59

8.3. and adiponectin concentrations in women’s bloodPeculiarities of serum leptin

under physiological and pathological conditions................................................. 63

CONCLUSIONS....................................................................................................... 66

10. LIST OF REFERENCES........................................................................................ 67

11. LIST OF PUBLICATIONS.................................................................................... 88

 

 

 

 

 

 

 

 

 

 

 

 

 

               

 

 

 

 

 

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MOSTLY USED CONCEPTS AND ABBREVIATIONS

AC –Atherogenic Coefficient

ABP –arterial blood pressure

AHA 2009 –A Joint Interim Statement of the International Diabetes Federation Task

Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute;

American Heart Association; World Heart Federation; International Atherosclerosis

Society; and International Association for the Study of Obesity recommended criteria of

diagnostics of the metabolic syndrome AHA/NHLBI –American Heart Association / National Heart, Lung, and Blood   Institute

AIP –Atherogenic Index of Plasma

BMI –body mass index

Ch –cholesterol

CHD –coronary heart disease

CI - confidence interval

DM –diabetes mellitus

GDM –gestational diabetes mellitus

HDL –high-density lipoprotein

IDF 2005–The International Diabetes Federation recommended criteria of diagnostics of

the metabolic syndrome

IUGR - intrauterine growth restriction

LDL – low-density lipoprotein

LPL –lipoprotein lipase

M –mean

Max –maximal value

Min –minimal value

MS –metabolic syndrome

NCEP/ATP III 2001–Third Report of the Expert Panel on Detection, Evaluation, and

Treatment of High Blood Cholesterol in Adults /Adult Treatment Panel III recommended

criteria of diagnostics of the metabolic syndrome

Non-HDL –non-high-density lipoprotein

OGTT –oral glucose tolerance test

OR –odds ratio

 

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