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BioMedNet News and CommentResearch Journal News & Books & Science WebReviewsTools Collection Comment Labware Jobs LinksLatest Today's Magazine Conference Journal Special My E-mail SectionCommentarynews.bmn.com Updates News HMS Beagle Reporter Scan Report Alerts SearchJoin LoginSFN 2001 - Day 4 - Wednesday 14 November 2001Feedback HelpJoin/Login Benefits Report: SFN 2001Grandmother calls in the reserves Society for NeuroscienceInvestigators: Roberto Cabeza, Nora Volkow, and ContentsNaftali RazConference Reporter SummaryWednesday Nov 14th, 2001 Information 1 2 3 5 Day: 4 by Roberta Friedman Latest ConferenceBoth the structure Future Conferences Day 4 Reports:and the function of (Investigator's name) Previous Conferencesthe brain take a hit To be remembered, Search Conferences with normal aging, forget praise. Give About This Section and research money. How To Cite Us presented here Prefrontal Cortex(Elizabeth Kensinger and confirms that 23-year old female (left) and 77 Editorial BoardKristy Nielson)successful elderly can year old female (right)* Staffnevertheless Is neurodegeneration compensate. Roberto Cabeza of Duke University in due to toxins, not Durham, North Carolina, bolstered his case for clumping?compensation with new evidence as well as previous (Steven Finkbeiner and studies by his group and others. The data show that Harry Orr)both hemispheres are brought to bear by elderly New Alzheimer's volunteers in mental tasks that in ...

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SFN 2001  Day 4  Wednesday 14 November 2001

Report: Grandmother calls in the reserves Investigators: Roberto Cabeza, Nora Volkow, and Naftali Raz

Wednesday Nov 14th, 2001

by Roberta Friedman

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SFN 2001 Society for Neuroscience Contents Summary Day: 123 4 5

Both the structure Day 4 Reports: and the function of (Investigator's name) the brain take a hit To be remembered, with normal aging, forget praise. Give and research money. presented here Prefrontal Cortex (Elizabeth Kensinger and confirms that 23year old female (left) and 77 Kristy Nielson) successful elderly can year old female (right)* nevertheless Is neurodegeneration compensate. Roberto Cabeza of Duke University in due to toxins, not Durham, North Carolina, bolstered his case for clumping? compensation with new evidence as well as previous (Steven Finkbeiner and studies by his group and others. The data show that Harry Orr) both hemispheres are brought to bear by elderly New Alzheimer's volunteers in mental tasks that in younger subjects dispute: Does vaccine require only one. restore cognition? (David Morgan, The prefrontal area of the brain takes the biggest hit in Christopher Janus, and normal aging, according to unpublished studies by Naftali Raz Ron DeMattos) at Wayne State University. Loss of prefrontal cortex also Grandmother calls in correlates with faltering cognitive performance in the older the reserves subjects. (Roberto Cabeza, Nora Volkow, and Naftali Raz) "I don't want to create the impression that all old people You're right, have these shriveled brains," Raz tellsBioMedNet News. "It's Shakespeare: Music a continuum." Longitudinal studies to follow individuals as and sweet poetry agree they age are sorely needed, he adds. "Still," he said, "I was (Robert Zatorre and surprised how close the behavior correlated with the Gregory Hickok) structural loss." Day 4 Profiles: Dale Schenk More evidence for loss of brain with age came from PET studies of the dopamine system by Brookhaven Laboratories View all Profiles researcher Nora Volkow. Not just receptors are lost; many different aspects of dopamine function decline with age. "For SFN Site the first time," she said in an interview, "we show it's not silent. It's associated with loss of performance on mental Printer ready version tasks." Email article to a friend Volkow estimates a 5% to 8% decline of the D2 receptors See also: with age. This is not a loss of cells, as in Parkinson's disease, but an acrosstheboard slowing of dopamine transmission, with less transmitter released and faster metabolism of that which is made.

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Cabeza's data, not yet published, give evidence that people who age successfully compensate for these losses by engaging both hemispheres, while the young use just one. Cabeza adds that studies of those who recover from stroke also show bilateral activity. The young also show action in both halves of the brain, he says, during complex mental tasks.

* Photo credit: Naftali Raz

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Aging cognition: from neuromodulation to representation [Opinion] ShuChen Li, Ulman Lindenberger and Sverker Sikström Trends in Cognitive Sciences, 2001, 5:11:479486 Changes in memory processing with age [Review article] Cheryl L Grady, Fergus IM Craik Current Opinion in Neurobiology, 2000, 10:224231

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