Out-of-hospital cardiac arrest during the COVID-19 pandemic in Paris, France: a population-based, observational study Eloi Marijon*, Nicole Karam*, Daniel Jost, David Perrot, Benoit Frattini, Clément Derkenne, Ardalan Sharifzadehgan, Victor Waldmann, Frankie Beganton,Kumar Narayanan, Antoine Lafont, Wulfran Bougouin, Xavier Jouven Summary Background Although mortality due to COVID-19 is, for the most part, robustly tracked, its indirect efect at the population level through lockdown, lifestyle changes, and reorganisation of health-care systems has not been evaluated. We aimed to assess the incidence and outcomes of out-of-hospital cardiac arrest (OHCA) in an urban region during the pandemic, compared with non-pandemic periods. Methods We did a population-based, observational study using data for non-traumatic OHCA (N=30768), systematically collected since May 15, 2011, in Paris and its suburbs, France, using the Paris Fire Brigade database, together with in-hospital data. We evaluated OHCA incidence and outcomes over a 6-week period during the pandemic in adult inhabitants of the study area. FindingsComparing the 521 OHCAs of the pandemic period (March 16 to April 26, 2020) to the mean of the 3052 total of the same weeks in the non-pandemic period (weeks 12–17, 2012–19), the maximum weekly OHCA incidence increased from 13·42 (95% CI 12·77–14·07) to 26·64 (25·72–27·53) per million inhabitants (p48 h before OHCA, with cough, dyspnoea, or both).
Outofhospital cardiac arrest during the COVID19 pandemic in Paris, France: a populationbased, observational study
Eloi Marijon*, Nicole Karam*, Daniel Jost, David Perrot, Benoit Frattini, Clément Derkenne, Ardalan Sharifzadehgan, Victor Waldmann, Frankie Beganton,Kumar Narayanan, Antoine Lafont, Wulfran Bougouin, Xavier Jouven
Summary BackgroundAlthough mortality due to COVID-19 is, or the most part, robustly tracked, its indirect efect at the population level through lockdown, liestyle changes, and reorganisation o health-care systems has not been evaluated. We aimed to assess the incidence and outcomes o out-o-hospital cardiac arrest (OHCA) in an urban region during the pandemic, compared with non-pandemic periods.
MethodsWe did a population-based, observational study using data or non-traumatic OHCA (N=30 768), systematically collected since May 15, 2011, in Paris and its suburbs, France, using the Paris Fire Brigade database, together with in-hospital data.We evaluated OHCA incidence and outcomes over a 6-week period during the pandemic in adult inhabitants o the study area.
FindingsComparing the 521 OHCAs o the pandemic period (March 16 to April 26, 2020) to the mean o the 3052 total o the same weeks in the non-pandemic period (weeks 12–17, 2012–19), the maximum weekly OHCA incidence increased rom 13·42 (95% CI 12·77–14·07) to 26·64 (25·72–27·53) per million inhabitants (p<0·0001), beore returning to normal in the final weeks o the pandemic period. Although patient demographics did not change substantially during the pandemic compared with the non-pandemic period (mean age 69·7 years [SD 17]vs68·5 [18], 334 males [64·4%]vs1826 [59·9%]), there was a higher rate o OHCA at home (460 [90·2%]vs[76·8%]; 2336 p<0·0001), less bystander cardiopulmonary resuscitation (239 [47·8%]vs[63·9%]; p<0·0001) and shockable 1165 rhythm (46 [9·2%]vs472 [19·1%]; p<0·0001), and longer delays to intervention (median 10·4 min [IQR 8·4–13·8]vs9·4 min [7·9–12·6]; p<0·0001). The proportion o patients who had an OHCA and were admitted alive decreased rom 22·8% to 12·8% (p<0·0001) in the pandemic period. Ater adjustment or potential conounders, the pandemic period remained significantly associated with lower survival rate at hospital admission (odds ratio0·36, 95% CI 0·24–0·52; p<0·0001). COVID-19 inection, confirmed or suspected, accountedor approximately a third o the increase in OHCA incidence during the pandemic.
InterpretationA transient two-times increase in OHCA incidence, coupled with a reduction in survival, was observed during the specified time period o the pandemic when compared with the equivalent time period in previous years with no pandemic. Although this result might be partly related to COVID-19 inections, indirect efects associated with lockdown and adjustment o health-care services to the pandemic are probable. Thereore, these actors should be taken into account when considering mortality data and public health strategies.
FundingThe French National Institute o Health and Medical Research (INSERM)
Introduction Sînce the emergence o severe acute respîratory syndrome coronavîrus 2 (SARS-CoV-2, the vîrus responsîbe or 1 2 COVID-19), înîtîay reported în Chîna în December, 2019, and subsequenty quaîfied as a goba pandemîc by WHO 3 on March 11, 2020, amost 5·1 mîîon cases o COVID-19 have been reported wordwîde, wîth more than 3,4 333 446 deaths as o May 23, 2020. Beyond the dîrect mortaîty caused by COVID-19, there are growîng concerns regardîng the consequences o the 5,6 COVID-19 pandemîc on heath systems. Lockdown and movement restrîctîons împosed în severa countrîes, as we as the ear o contamînatîon în hospîtas, coud have ed to a reuctance by patîents to ca emergency medîca servîces (EMS) or present to emergency departments,
resutîng în suboptîma heath care and deays. Addîtîo-nay, entîre heath-care systems have been reorganîsed to cope wîth thîs unprecedented surge o patîents wîth a nove dîsease that îs hîghy contagîous. Deerabe routîne medîca actîvîty, încudîng schedued hospîtaîsatîons and consutatîons, were canceed to ocus on care or patîents wîth COVID-19, and avoîd unnecessary exposure o stabe patîents to the rîsk o contamînatîon at the hospîta. Atogether, these îndîrect efects o the COVID-19 pandemîc coud have detrîmenta efects on popuatîon heath. Out-o-hospîta cardîac arrest (OHCA) coud be a vauabe surrogate or both popuatîon heath and eicacy o the heath-care system în handîng emergencîes. Athough a ew medîa reports have suggested an încrease
www.thelancet.com/publichealthPublished online May 27, 2020 https://doi.org/10.1016/S24682667(20)301171
Université de Paris, Centre de Recherche Cardiovasculaire de Paris, INSERM, Paris, France(Prof E Marijon MD, N Karam MD, D Perrot MD, A Sharifzadehgan MD, V Waldmann MD, F Beganton MS, Prof A Lafont MD, W Bougouin MD, Prof X Jouven MD); Paris Sudden Death Expertise Center, Paris, France(Prof E Marijon, N Karam, D Jost MD, D Perrot, A Sharifzadehgan, V Waldmann, F Beganton, K Narayanan MD, Prof A Lafont, W Bougouin, Prof X Jouven); European Georges Pompidou Hospital, Cardiology Department, Paris, France(Prof E Marijon, N Karam, A Sharifzadehgan, V Waldmann, Prof A Lafont, Prof X Jouven); Paris Fire Brigade, Paris, France(D Jost, B Frattini MD, C Derkenne MD); and Jacques Cartier Hospital, Intensive Care Unit, Massy, France(W Bougouin)
Correspondence to: Prof Eloi Marijon, Unité de Rythmologie, Département de Cardiologie, Hôpital Européen Georges Pompidou, Paris 75015, France eloi_marijon@yahoo.fr
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Research in context
Evidence before this study After emerging in late2019, the world has been struggling with an outbreak of a novel disease, COVID19, declared a pandemic in March, 2020. The pandemic has led to worldwide lockdowns, reorganisation of healthcare systems, and postponement of nonurgent medical consultations and interventions. We searched the press media daily and PubMed from database inception, up to May 7, 2020, for reports on outofhospital cardiac arrest (OHCA) during the pandemic, using the keywords “cardiac arrest”, “sudden death”, “healthcare”, “emergency medical services”, AND “COVID19”, “SARSCoV2”, “lockdown” with no language restrictions. Although some media outletshave suggested an increase in OHCA in some regions, only one peerreviewed article described an increase in OHCA incidence in Lombardy, an Italian province where the pandemic was particularly damaging with severe overwhelming of the healthcare system, beyond what was experienced in most other regions thus far.
în the încîdence o OHCA în severa cîtîes, to the best o our knowedge, ony one orîgîna report descrîbed an încrease în OHCA încîdence în Lombardy, Itay, a settîng 6,7 where the înectîon has been partîcuary devastatîng. In thîs study, we aîmed to assess the încîdence and outcomes o OHCA durîng the ongoîng COVID-19 pandemîc, compared wîth non-pandemîc perîods usîng a rea-tîme mutîsource surveîance system set up în 2011, în an urban regîon (Parîs and îts suburbs, France).
Methods Study design and participants Thîs popuatîon-based, observatîona study îs reported accordîng to the strengthenîng the reportîng o obser-8 vatîona studîes în epîdemîoogy guîdeînes. The Parîs-Sudden Death Expertîse Center (Parîs-SDEC) 9–11 ongoîng regîstry has been prevîousy descrîbed. A cases o sudden OHCA occurrîng among aduts (aged 18 years and oder) în the cîty o Parîs and îts three suburbs (Hauts-de-Seîne, Seîne-Saînt-Denîs, and Va-de-Marne), an area coverîng 762 km², have been încuded în the Parîs-SDEC regîstry sînce May 15, 2011. Each case was revîewed separatey by two învestîgators to ensure accuracy o cassîficatîon. Severa quaîty assessments were done to 9 ascertaîn the competeness o coectîon în the area. In Parîs and îts suburbs (6·8 mîîons înhabîtants), patîents wîth OHCA are managed by the Parîs EMS, a two-tîered response system, coordînated vîa a unîque dîspatch centre (not changed durîng the pandemîc 12,13 perîod): (1) a basîc îe support tîer provîded by 197 basîc îe support teams rom the Parîs Fîre Brîgade (Brîgade des Sapeurs Pompîers de Parîs), who can appy an automatîc externa defibrîator, and (2) an advanced cardîac îe support unctîon provîded by ambuance
Added value of this study Our study showed the course of OHCA incidence and outcomes during the COVID19 pandemic in Paris and its suburbs (6∙8 million inhabitants), from the beginning of the surge in infections and lockdown, until the decrease in its incidence. Our results showed a transient twotimes increase in OHCA incidence, coupled with a significant reduction in survival, followed by a return to normal towards the end of the study period. Although our findings might be partly related to direct COVID19 deaths—patients suspected to have or had received a diagnosis of COVID19 accounted for a third of the increase in cases of OHCA—indirect effects related to lockdown and adjustment of healthcare services to the pandemic are probable.
Implications of all the available evidence This increase in OHCA incidence highlights the collateral deaths, not taken into account in COVID19 death statistics, and that should be considered when establishing public health strategies for dealing with the pandemic.
teams wîth a physîcîan, a nurse, and a paramedîc (Parîs Fîre Brîgade or Servîce d’Aîde Médîcae Urgente). The Parîs Fîre Brîgade teams usuay arrîve on scene first and provîde basîc îe support accordîng to the guîdeînes or OHCA management. The Parîs Fîre Brîgade then cas or advanced îe support î consîdered useu accordîng to case presentatîon. Non-traumatîc OHCA was defined as any cardîac arrest, ater excusîon o cases wîth obvîous accîdenta causes, îrrespectîve o whether resuscîtatîon was attempted or not. 14 Data were coected usîng Utsteîn tempates. Athough there has been no change în the system configuratîon and case detectîon durîng the study perîod, încudîng durîng the pandemîc, firefighters rom the Parîs Fîre Brîgade have had to constanty adapt theîr practîces. They have had to take contagîousness înto account, whîe compyîng wîth înternatîona recommendatîons or whîch a dedîcated 15 COVID-19 versîon has been pubîshed. Dîspatchers rom the Parîs Fîre Brîgade were înstructed to învestîgate when receîvîng the ca whether the patîent was known to be COVID-19-posîtîve or had symptoms suggestîve o COVID-19 înectîon (ever astîng >48 h beore OHCA, wîth cough, dyspnoea, or both). When COVID-19 înectîon was confirmed or suspected, EMS personne were înstructed to protect themseves by wearîng persona protectîve equîpment beore înîtîatîng 15 attempted resuscîtatîon. The revîew boards approved the Parîs-SDEC regîstry (Commîssîon Natîonae de ’Inormatîque et des Lîbertés approva #912309 and Comîté Consutatî sur e Traîtement de ’Inormatîon en matîère de Recherche dans e domaîne de a Santé approva #12336). No înormed consent was requîred.
www.thelancet.com/publichealthPublished online May 27, 2020 https://doi.org/10.1016/S24682667(20)301171
Procedures Genera data, încudîng Utsteîn characterîstîcs o the 14 OHCA, were recorded prospectîvey. Response tîme îs defined as the deay between EMS ca and arrîva (îe, ca answer to arrîva tîme). For the current anaysîs, gîven the French COVID-19 epîdemîc trajectory, we consîdered the perîod rom March 16 (Parîs Lockdown began March 17) to Aprî 26, 2020, as the 6 weeks o the pandemîc în the Parîs regîon (correspondîng to weeks 12–17 o 2020). We compared patîent characterîstîcs, settîng o occurrence, and outcome o thîs perîod or OHCA reported by the Parîs Fîre Brîgade wîth the mean or weeks 12–17 o each year rom 2012 to 2019 (non-pandemîc reerence perîod 1). We aso reported data or patîents în the Parîs-SDEC regîstry rom 2011 to 2020, excudîng weeks 12–17 (non-pandemîc reerence perîod 2). A new varîabe was added to the EMS database, reated to COVID-19 status (confirmed or suspected), whîch aowed us to trace COVID-19 status among patîents who had an OHCA (eîther wîtnessed or admîtted aîve).
Statistical analysis Contînuous data are presented as mean (SD) or medîan (IQR), dependîng on dîstrîbutîon, and categorîca data are presented as n (%). Contînuous varîabes were compared wîth Student’stthe Mann-Whîtney test, test, or the Kruska-Waîs test as approprîate, and categorîca varîabes were compared usîng the χ² test. The maxîmum weeky încîdence o OHCA durîng the pandemîc perîod (weeks 13 and 14) was compared wîth the încîdence o OHCA durîng the non-pandemîc perîod 1 (weeks 13 and 14, rom 2012–19). The încîdences o OHCA and theîr 95% CIs were estîmated by consîderîng the popuatîon aged 18 years or oder o the our dîstrîcts. For weeks 12–17, substantîa popu-atîon mîgratîon outsîde Parîs and îts suburbs was observed and taken înto account în each dîstrîct, based on the data o the Natîona Instîtute o Statîstîcs and Economîc Studîes(ast assessed on May 6, 2020). O note, Parîs ockdown was maîntaîned throughout the pandemîc perîod, and the subset o the popuatîon who et dîd not return because o movement restrîctîons. Addîtîona data or în-hospîta mortaîty as we as hospîtaîsatîons reated to COVID-19 în the study area were aso coected rom the Natîona Instîtute o Statîstîcs and Economîc Studîes (ast assessed May 1, 2020). Mutîvarîabe ogîstîc regressîon anaysîs was done to assess the assocîatîon o the pandemîc perîod wîth survîva at hospîta admîssîon. Odd ratîos (ORs) and theîr 95% CIs were cacuated wîth adjustment or potentîa conoundîng actors încudîng sex, age, ocatîon, bystander cardîopumonary resuscîtatîon, use o automatîc externa defibrîator beore EMS arrîva, shockabe cardîac rhythm, and ca answer to arrîva deay.
Sex Women
Men
Age, years Home location
Witness
Cardiopulmonary resuscitation initiated Public automatic external defibrillator use Shockable rhythm
Median response time, min Call answer to arrival 10∙4 (8∙4–13∙8) 9∙4 (7∙9–12∙6) 9∙3 (7∙8–12∙4) <0∙0001 On road 6∙4 (4∙3–8∙5) 5∙1 (3∙0–8∙1) 5∙0 (3∙0–7∙1) <0∙0001 Survival at hospital 67/521 (12∙9%) 695/3052 (22∙8%) 6230/27 195 <0∙0001 admission (22∙9%) Survival at hospital discharge 16/517 (3∙1%) 164/3052 (5∙4%) 1450/5731 (5∙3%) 0∙0001 Data are n (%), mean (SD), or median (IQR). The pandemic period was defined as the period from March 16 to April 26, 2020, considered as the 6 weeks of the pandemic in the Paris region. Paris lockdown began on March 17. The nonpandemic period 1 was defined as weeks 12–17 of each year from 2012 to 2019. The nonpandemic period 2 was defined as data for patients included in the ParisSudden Death Expertise Center registry from 2011 to 2020, excluding weeks 12–17. OHCA=outofhospital cardiac arrest.
Table 1:Baseline characteristics, initial management, and outcome of OHCA
p vaues ess than 0·05 were consîdered statîstîcay sîgnîficant. Statîstîca anaysîs was done usîng R sot-ware, versîon 3.6.1.
Role of the funding source The under o the study had no roe în study desîgn, data coectîon, data anaysîs, data înterpretatîon, or wrîtîng o the report. The correspondîng author had u access to a the data în the studyand had fina responsîbîîty or the decîsîon tosubmît or pubîcatîon.
Results Our study took pace between March 16 and Aprî 26, 2020. Overa, rom May 15, 2011, to Aprî 26, 2020, there were 30 768 cases o OHCA în the Parîs area. The mean age o patîents was 68·4 years (SD 18), and 19 002 (61·9%) were men. OHCA occurred at home în 23 282 (76·1%) cases and în pubîc paces în 7334 (23·9%) cases. A wîtness was present în 18 781 (66·1%) cases, and cardîopumonary resuscîtatîon was înîtîated în 11 184 (60·6%) cases. An automatîc externa defibrîator was used în 368 (3·3%) cases beore EMS arrîva. Overa, 4713 (19·0%) patîents wîth OHCA presented wîth shockabe rhythm (ventrîcuar tachycardîa or fibrîatîon), and 6992 (22·7%) were admîtted aîve în one o the 48 hospîtas o the area. Patîent characterîstîcs and cîrcumstances o OHCA occurrence are reported în tabe 1. Durîng the
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For theNational Institute of Statistics and Economic Studiessee https://www.insee. fr/en/accueil
OHCA surge was seen în the departments wîth a ow densîty o medîca acîîtîes (eg, northeast o Parîs) wîth an OHCA încrease per mîîon înhabîtants o 28·33 (95% CI 26·94–29·71) compared wîth departments wîth a hîgh densîty o medîca acîîtîes (eg, Centra Parîs and West Parîs) wîth an OHCA încrease per mîîon înhabîtants o 13·62 (12·79–14·46; p<0·0001; figure 2). Patîent characterîstîcs dîd not substantîay dîfer durîng the pandemîc compared wîth the same non-pandemîc perîod în terms o age (69·7 years [SD 17]vs 68·5 years [18]; p=0·061) and proportîon o men (334 [64·4%]vs1826 [59·9%], p=0·057). By contrast, dîferences were observed în the cîrcumstances o occurrence o the OHCA. 460 OHCAs occurred at home (460 [90·2%]vs 2336 [76·8%] or the same non-pandemîc perîod; p<0·0001). Addîtîonay, ess shockabe cardîac rhythm at EMS arrîva (46 [9·2%]vs[19·1%]; p<0·0001), and ess use o an 472 automatîc externa defibrîator was observed (0·4%vs3·0%, p=0·0009; tabe 1). Response tîme, defined as ca answer to EMS arrîva, was sîgnîficanty onger (p<0·0001). Durîng the pandemîc perîod, the proportîon o OHCAs wîth resuscîtatîon attempt and advanced îe support was ower than usua (53·1%vs 66·2%, p<0·0001), and survîva at hospîta admîssîon decreased rom 22·8% to 12·8% (p<0·0001), wîth a return to usua încîdence oowed by a return to usua survîva range towards the end o the perîod (figure 3). In mutî-varîabe ogîstîc regressîon anaysîs, ater consîderîng
Number of OHCAs in 2020 Incidence of OHCAs in 2020, per million Population in 2020, in millions Paris (district 75) HautsdeSeine (district 92) SeineSaintDenis (district 93) ValdeMarne (district 94) Number of OHCAs in 2019 Incidence of OHCAs in 2019, per million Population in 2019, in millions Paris (district 75) HautsdeSeine (district 92) SeineSaintDenis (district 93) ValdeMarne (district 94) Mean number of OHCAs between 2012–18 Mean incidence of OHCAs between 2012–18, per million Mean population between 2012–18, in millions Paris (district 75) HautsdeSeine (district 92) SeineSaintDenis (district 93) ValdeMarne (district 94) OHCA=outofhospital cardiac arrest.
5∙31 1∙83 1∙24 1∙17 1∙06
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Table 2:Number, population, and weekly incidences in the different districts of Paris and its suburbs
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pandemîc perîod (March 16 to Aprî 26, 2020), 521 OHCAs occurred, gîvîng a maxîma weeky încîdence o 26·64 (95% CI 25·72–27·53) per mîîon înhabîtants (weeks 13 and 14), sîgnîficanty hîgher than the maxîma weeky încîdencedurîng the same perîod between 2012 and 2019 (13·42, 95% CI 12·77–14·07; p<0·0001), wîth a rapîd return to norma în the fina weeks o the pandemîc perîod (figure 1, tabe 2). A geographîca heterogeneîty was ound în terms o OHCA încrease. A sîgnîficanty greater
Figure 1:Weekly incidences of OHCA during the first 17 weeks of years 2012 to 2020 Compared with previous years and with the beginning of 2020, there was a surge in OHCA incidence starting week 12 of 2020, with a rapid return to normal by week 15. OHCA=outofhospital cardiac arrest.
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potentîa conoundîng actors încudîng sex, age, ocatîon, bystander cardîopumonary resuscîtatîon, use o automatîc externa defibrîator beore EMS arrîva, shockabe cardîac rhythm, and ca answer to arrîva deay, the pandemîc perîod remaîned sîgnîficanty assocîated wîth ower survîva at hospîta admîssîon (odds ratîo 0·36, 95% CI 0·24–0·52; p<0·0001). Survîva status at hospîta dîscharge was known în 63 (94·0%) o 67 patîents admîtted aîve. Overa, 16 (3·1%) were dîs-charged aîve, compared wîth 164 (5·4%) în the same non-pandemîc perîod (p=0·029). In the Parîs area, the maxîma number o new hospîtaîsatîons reated to COVID-19 was reached în weeks 13 and 14 (4402 patîents; both întensîve and non-întensîve care unîts; appendîx p 1),whereas maxîma COVID-reated în-hospîta mortaîty was observed durîng weeks 14 and 15 (1383 în-hospîta deaths overa), then ît decreased aterwards. 42 patîents were suspected to have COVID-19 (n=17) or had receîved a dîagnosîs o COVID-19 (n=25); these numbers account or approxîmatey a thîrd o the încrease în cases o OHCA observed în Parîs and îts suburbs durîng the pandemîc perîod. O note, among those admîtted aîve, screenîng or COVID-19 was done în 20 (32%) patîents whereas 43 (68%) were not tested.
Discussion Durîng the COVID-19 pandemîc, the number o OHCAs occurrîng în Parîs and îts suburbswîthîn the specîfied peak perîod amost doubed. OHCA survîva rate to hospîta admîssîon was markedy reduced as we, eadîng to a major rîse în OHCA-reated deaths durîng the pandemîc, whîch started decînîng at the end o the study perîod. Athough these findîngs mîght be party reated to dîrect COVID-19 deaths, îndîrect efects through ockdown, behavîour changes, and pandemîc-reated heath system îssues (overwhemîng o EMS and postponement o consutatîons and schedued non-urgent procedures) are probabe. Data rom the past 9 years o the Parîs-SDEC regîstry îndîcate that the încîdence o OHCA has been stabe over tîme în Parîs and îts suburbs, whîch îs în contrast wîth the major încrease observed durîng the pandemîc perîod. Both dîrect and îndîrect efects o COVID-19 mîght expaîn thîs încreased încîdence. The ethaîty o COVID-19 through acute respîratory dîstress syndrome or an excessîve îmmune response îs 16 we estabîshed. It îs thereore possîbe that some o the OHCAs observed durîng the pandemîc are actuay respîratory deaths among patîents wîth COVID-19 who were not hospîtaîsed. Addîtîonay, COVID-19 can ead to cardîovascuar înjury and myocardîtîs; experîmenta treatments such as hydroxychoroquîne or azîthromycîn 17 mîght aso ead to încreased cardîac events. Acute cardîac events have been observed în patîents wîth COVID-19, încudîng acute coronary syndromes, heart aîure, and arrhythmîas, thereore makîng OHCA a
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Figure 2:Density of medical facilities and surge in OHCA incidence across Paris and its suburbs during the pandemic period Significant differences exist in the density of hospitals and mobile intensive care units in the Paris area, with the highest density observed in central Paris. The highest increase in OHCA incidence was observed in areas with a low density of medical facilities. BSPP=Brigade de SapeursPompiers de Paris. SAMU=Service d’Aide Médicale Urgente. OHCA=outofhospital cardiac arrest.
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Figure 3:Proportion of patients admitted alive at hospital during weeks 5–17 of 2020 compared with the same period in previous years Compared with similar periods in the previous years, there was a decrease in OHCA survival at hospital admission during the pandemic period of 2020. OHCA=outofhospital cardiac arrest.
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possîbe dîrect compîcatîon o COVID-19. Fînay, a major prothrombotîc state has been reported durîng COVID-19 înectîons, wîth a consequent încrease în thromboemboîc events încudîng pumonary emboîsms 18 and acute coronary syndromes. To the best o our knowedge, ony one orîgîna report descrîbed an încrease în OHCA încîdence în Lombardy, Itay, a specîfic settîng where the pandemîc was more proîfic than what was 6,7 observed în most regîons wordwîde. Overwhemîng o medîca servîces occurred and rues were set to prîorîtîse hospîta admîssîons and întubatîon among patîents wîth COVID-19. Thîs îssue coud have ed to severa deaths rom COVID-19 occurrîng at home and beîng counted as OHCA, as suggested by the hîgh rate o COVID-19 suspîcîon or dîagnosîs among patîents who had an OHCA, whîch accounted or 77% o the surge în OHCA cases în Lombardy. Conversey, în our study, we provîde a pîcture o the surge o OHCA în a settîng where a severe pandemîc was observed, but the heath-care system was stî abe to hande a knownCOVID-19 cases wîthout specîfic îmîtatîons, eadîng to a much ower proportîon o cases beîng reated to COVID-19 înectîon. Among patîents who were negatîve or COVID-19, an îndîrect efect, reated to changes în pubîc behavîour and reorganîsatîon o the heath-care system, mîght have 19 ed to an încrease în OHCA în the pandemîc settîng. Wîth ockdown and movement restrîctîons, patîents have more dîicuty în seekîng medîca advîce. They mîght aso be reuctant to present to emergency departments or doctors’ oices because o ears o COVID-19 înectîon, or ong waîtîng tîmes. In addîtîon, stabe înterventîons and consutatîons had to be postponed to prîorîtîse COVID-19-reated îssues and avoîd exposîng patîents to an unnecessary rîsk o contamînatîon at the hospîta or medîca oice. Fînay, the efect o încreased psycho-ogîca stress durîng a pandemîc, brought about by ear, restrîctîon o movement, and grîe due to oss o oved ones, can aso potentîay trîgger adverse cardîac events and arrhythmîas, utîmatey eadîng to OHCA. In addîtîon to the marked încrease în OHCA încîdence, we aso noted a drastîc reductîon în survîva to hospîta admîssîon. Wîtnesses and emergency responders mîght have been reuctant to do cardîopumonary resuscîtatîon on potentîay înected cases, as cardîopumonary resus-cîtatîon îs consîdered an aeroso-generatîng procedure 20 wîth substantîa rîsk o transmîssîon. Some hospîtas îssued dîrectîves prohîbîtîng cardîopumonary resus-cîtatîon or patîents who potentîay have COVID-19 21 uness u persona protectîve equîpment îs worn, whîch coud be împractîca în the out-o-hospîta settîng. Besîdes, more OHCAs occurred at home where the wîtnesses present durîng the tîme o ockdown are most îkey to be amîy members, and are ess îkey to do cardîopumonary resuscîtatîon due to emotîona învovement and psycho-22–24 ogîca actors. Fînay, OHCA occurrîng în patîents who were hypoxaemîc wîth COVID-19, and OHCA reated to advanced cardîac înjury such as în ate presenters o
acute myocardîa înarctîon, mîght have worse survîva compared wîth OHCA o cardîac orîgîn. Durîng the ast 2 weeks o the study perîod, there was a reatîve decrease în OHCA încîdence athough survîva to hospîta admîssîon remaîned ow. The EMS had been reorganîsed to some extent aowîng a progressîvey better response to non-COVID-19 reated cas durîng the study perîod. Teeconsutatîons were deveoped, and pubîc campaîgns were made to encourage seekîng o medîca attentîon or symptoms not reated to COVID-19, whîch probaby prompted patîents to get eary medîca care upon onset o cardîac symptoms, beore OHCA occurrence. The deay în împrovement în survîva rate compared wîth încîdence îs unsurprîsîng, gîven the persîstent ow cardîopumonary resuscîtatîon rate among amîy members and bed shortages în întensîve care unîts, whîch obîgated EMS to careuy trîage OHCA cases îkey to benefit rom hospîta transer. Athough our study îs one o the first to descrîbe the îndîrect efect o the ongoîng COVID-19 pandemîc at the 6 popuatîon eve, some îmîtatîons need to be acknow-edged. Fîrst, athough we have shown a major încrease în absoute OHCA numbers, thîs change în încîdence does not account or the decrease în tourîsm flow known to be very împortant at thîs perîod în Parîs; gîven the absence o tourîsts durîng the pandemîc, we mîght have expected a ower number o OHCAs durîng the pandemîc, potentîay underestîmatîng the surge o OHCA that woud have occurred î tourîsts had been present. Second, athough COVID-19 status was con-firmed în ess than 10% o patîents, în others, COVID-19 status was eîther based on the patîent’s symptoms or unknown. The exact proportîon o COVID-19 reated OHCAs thereore remaîns unknown. Addîtîonay, some OHCAs mîght have occurred în înected patîents wîthout beîng due to the înectîon. Fînay, the study was done în Parîs and îts suburbs and specîficîtîes reated to the ocatîon, încudîng heath-care system organîsatîon, mîght not be generaîsabe to other countrîes. Durîng the COVID-19 pandemîc în the Parîs area, we observed a sîgnîficant and transîent încrease în the încîdence o OHCA, couped wîth a major reductîon în survîva at hospîta admîssîon. Athough thîs findîng mîght be party reated to dîrect COVID-19 deaths, îndîrect efects reated to ockdown and reorganîsatîon o heath-care systems mîght account or a substantîa part. Contributors EM, NK, DJ, WB, and XJ were responsîbe or the study concept and desîgn. EM, NK, DP, and WB were responsîbe or the îterature search. EM, NK, DJ, FB, AS, VW, BF, and CD were responsîbe or acquîsîtîon o data. EM, NK, DJ, DP, WB, and XJ were responsîbe or anaysîs and înterpretatîon o data. EM, NK, KN, WB, XJ were responsîbe or dratîng o the manuscrîpt. DJ, AS, VW, KN, and AL were responsîbe or crîtîca revîsîon o the manuscrîpt or împortant înteectua content. EM, NK, BF, and DP were responsîbe or statîstîca anaysîs. EM, NK, and DP were responsîbe or figures. EM and XJ had u access to a o the data în the study and take responsîbîîty or the întegrîty o the data and the accuracy o the data anaysîs.
www.thelancet.com/publichealthhttps://doi.org/10.1016/S24682667(20)301171Published online May 27, 2020
Declaration of interests We decare no competîng înterests.
Acknowledgments We thank the Parîs-SDEC or provîdîng the ogîstîca support that aowed us to access and anayse the necessary data or the manuscrîpt în such a short perîod, and the Parîs-SDEC coaborators or theîr mutîdîscîpînary expertîse that aows an optîma approach în the fight agaînst sudden cardîac death through thîs coaboratîve network sînce 2011. The Parîs-SDEC actîvîtîes are supported by the Instîtut Natîona de a Santé et de a Recherche Médîcae (INSERM), Unîversîty o Parîs, Assîstance Pubîque-Hôpîtaux de Parîs, Fondatîon Coeur et Artères, Goba Heart Watch, Fédératîon Françaîse de Cardîoogîe, Socîété Françaîse de Cardîoogîe, Fondatîon Recherche Medîcae, as we as unrestrîcted grants rom îndustrîa partners (Medtronîc, Abbott, Boston Scîentîfic, MîcroPort, Bîotronîk, and Zo). SDEC Executîve Commîttee îs part o the ESCAPE-NET project (Horîzon2020 programme). We woud îke to aknowedge the huge efort o the Parîs Fîre Brîgade în prospectîvey provîdîng a data regardîng OHCA în a rea-tîme manner, and despîte the overwhemîng COVID-19 pandemîc.
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www.thelancet.com/publichealthPublished online May 27, 2020 https://doi.org/10.1016/S24682667(20)301171